PMID- 28006695
OWN - NLM
STAT- MEDLINE
DCOM- 20170321
LR  - 20170321
IS  - 1879-1336 (Electronic)
IS  - 1054-8807 (Linking)
VI  - 27
DP  - 2017 Mar-Apr
TI  - Role of atrial endothelial cells in the development of atrial fibrosis and 
      fibrillation in response to pressure overload.
PG  - 18-25
LID - S1054-8807(16)30118-1 [pii]
LID - 10.1016/j.carpath.2016.12.001 [doi]
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1)-mediated inflammatory 
      mechanisms have been shown to play a crucial role in atrial fibrosis induced by 
      pressure overload. In the present study, we investigated whether left atrial 
      endothelial cells would quickly respond structurally and functionally to pressure 
      overload to trigger atrial fibrosis and fibrillation. METHODS AND RESULTS: 
      Six-week-old male Sprague-Dawley rats underwent suprarenal abdominal aortic 
      constriction (AAC) or a sham operation. By day 3 after surgery, macrophages were 
      observed to infiltrate into the endocardium. The expression of MCP-1 and 
      E-selectin in atrial endothelium and the expression of intercellular adhesion 
      molecule-1, vascular cell adhesion molecule-1, and ED1 in left atrial tissue were 
      enhanced. Atrial endothelial cells were irregularly hypertrophied with the 
      disarrangement of lines of cells by scanning electron microscopy. Various-sized 
      gap formations appeared along the border in atrial endothelial cells, and several 
      macrophages were located just in the endothelial gap. Along with the development 
      of heterogeneous interstitial fibrosis, interatrial conduction time was prolonged 
      and the inducibility of atrial fibrillation by programmed extrastimuli was 
      increased in the AAC rats compared to the sham-operated rats. CONCLUSIONS: Atrial 
      endothelium responds rapidly to pressure overload by expressing adhesion 
      molecules and MCP-1, which induce macrophage infiltration into the atrial 
      tissues. These processes could be an initial step in the development of atrial 
      remodeling for atrial fibrillation.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Kume, Osamu
AU  - Kume O
AD  - Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita 
      University, Oita, Japan.
FAU - Teshima, Yasushi
AU  - Teshima Y
AD  - Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita 
      University, Oita, Japan. Electronic address: teshima@oita-u.ac.jp.
FAU - Abe, Ichitaro
AU  - Abe I
AD  - Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita 
      University, Oita, Japan.
FAU - Ikebe, Yuki
AU  - Ikebe Y
AD  - Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita 
      University, Oita, Japan.
FAU - Oniki, Takahiro
AU  - Oniki T
AD  - Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita 
      University, Oita, Japan.
FAU - Kondo, Hidekazu
AU  - Kondo H
AD  - Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita 
      University, Oita, Japan.
FAU - Saito, Shotaro
AU  - Saito S
AD  - Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita 
      University, Oita, Japan.
FAU - Fukui, Akira
AU  - Fukui A
AD  - Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita 
      University, Oita, Japan.
FAU - Yufu, Kunio
AU  - Yufu K
AD  - Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita 
      University, Oita, Japan.
FAU - Miura, Masahiro
AU  - Miura M
AD  - Department of Human Anatomy, Faculty of Medicine, Oita University, Oita, Japan.
FAU - Shimada, Tatsuo
AU  - Shimada T
AD  - College of Judo Therapy and Acupuncture-Moxibustion, Oita Medical Technology 
      School, Oita, Japan.
FAU - Takahashi, Naohiko
AU  - Takahashi N
AD  - Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita 
      University, Oita, Japan.
LA  - eng
PT  - Journal Article
DEP - 20161215
PL  - United States
TA  - Cardiovasc Pathol
JT  - Cardiovascular pathology : the official journal of the Society for Cardiovascular 
      Pathology
JID - 9212060
SB  - IM
MH  - Animals
MH  - Atrial Fibrillation/*pathology
MH  - Blotting, Western
MH  - Disease Models, Animal
MH  - Endothelial Cells/*pathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fibrosis/pathology
MH  - Heart Atria/*pathology
MH  - Hypertension/complications
MH  - Immunohistochemistry
MH  - Isolated Heart Preparation
MH  - Male
MH  - Microscopy, Electron, Scanning
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Atrial fibrillation
OT  - Endothelium
OT  - Fibrosis
OT  - Inflammation
OT  - Pressure overload
EDAT- 2016/12/23 06:00
MHDA- 2017/03/23 06:00
CRDT- 2016/12/23 06:00
PHST- 2016/09/07 00:00 [received]
PHST- 2016/11/09 00:00 [revised]
PHST- 2016/12/06 00:00 [accepted]
PHST- 2016/12/23 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
PHST- 2016/12/23 06:00 [entrez]
AID - S1054-8807(16)30118-1 [pii]
AID - 10.1016/j.carpath.2016.12.001 [doi]
PST - ppublish
SO  - Cardiovasc Pathol. 2017 Mar-Apr;27:18-25. doi: 10.1016/j.carpath.2016.12.001. 
      Epub 2016 Dec 15.