PMID- 28007637
OWN - NLM
STAT- MEDLINE
DCOM- 20170207
LR  - 20240327
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 266
DP  - 2017 Jan 15
TI  - Reproductive toxicity of linuron following gestational exposure in rats and 
      underlying mechanisms.
PG  - 49-55
LID - S0378-4274(16)33356-2 [pii]
LID - 10.1016/j.toxlet.2016.12.013 [doi]
AB  - Linuron is a widely used herbicide in agriculture; its endocrine disruptive 
      toxicity has recently received public attention. This study was designed to 
      examine the developmental toxicity of linuron on the reproductive system of male 
      offspring following maternal exposure. Mother rats received oral gavages of 
      linuron, once daily, at the dose of 0, 50, 100, 150 or 200mg/kg, from gestational 
      day (GD)13 to GD18; gonadal organs from GD20 fetuses were examined. Data 
      indicated that exposed male offspring had a significantly shortened anogenital 
      distance. Pathological examination further revealed a lack of fusion in the 
      urogenital fold in treated fetuses, the damaged seminiferous tubules, and the 
      injured Leydig cell ultrastructure. Analysis of serum testosterone concentrations 
      at postnatal day (PND)2 showed a significant dose-related reduction (about 
      33.7-58.75%, r=-0.838, p<0.05) as compared to controls. Immunohistochemical 
      results demonstrated a significantly reduced expression of enzymes pertinent to 
      the testosterone production including P450scc, 3beta-HSD, and PCNA in Leydig cells 
      (p<0.05). qPCR studies confirmed decreased levels of mRNAs encoding P450scc, 
      3beta-HSD and PCNA (p<0.05). Taken together, these data suggest that maternal 
      exposure to linuron hampers the male gonadal organ development; this appears to 
      be due to linuron's direct action on the production of testosterone in fetal and 
      postnatal offspring.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Ding, Hongwei
AU  - Ding H
AD  - Department of Hygiene Toxicology, School of Public Health, Zunyi Medical College, 
      Zunyi, Guizhou, PR China.
FAU - Zheng, Wei
AU  - Zheng W
AD  - School of Health Sciences, Purdue University, West Lafayette, IN, USA.
FAU - Han, Hua
AU  - Han H
AD  - Department of Hygiene Toxicology, School of Public Health, Zunyi Medical College, 
      Zunyi, Guizhou, PR China.
FAU - Hu, Xiyin
AU  - Hu X
AD  - Department of Hygiene Toxicology, School of Public Health, Zunyi Medical College, 
      Zunyi, Guizhou, PR China.
FAU - Hu, Binli
AU  - Hu B
AD  - Department of Hygiene Toxicology, School of Public Health, Zunyi Medical College, 
      Zunyi, Guizhou, PR China.
FAU - Wang, Feng
AU  - Wang F
AD  - Department of Hygiene Toxicology, School of Public Health, Zunyi Medical College, 
      Zunyi, Guizhou, PR China.
FAU - Su, Liyu
AU  - Su L
AD  - Department of Hygiene Toxicology, School of Public Health, Zunyi Medical College, 
      Zunyi, Guizhou, PR China.
FAU - Li, Hong
AU  - Li H
AD  - Department of Hygiene Toxicology, School of Public Health, Zunyi Medical College, 
      Zunyi, Guizhou, PR China.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Hygiene Toxicology, School of Public Health, Zunyi Medical College, 
      Zunyi, Guizhou, PR China. Electronic address: liyan067321@sina.com.
LA  - eng
GR  - R01 ES008146/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20161219
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Herbicides)
RN  - 01XP1SU59O (Linuron)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Genitalia, Male/drug effects
MH  - Herbicides/administration & dosage/*toxicity
MH  - Linuron/administration & dosage/*toxicity
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Testosterone/blood
PMC - PMC5697898
MID - NIHMS917152
OTO - NOTNLM
OT  - Developmental toxicity
OT  - Fetus
OT  - Leydig cells
OT  - Linuron
OT  - Offspring
OT  - Reproductive toxicity
OT  - Testosterone
COIS- Conflict of interest None.
EDAT- 2016/12/23 06:00
MHDA- 2017/02/09 06:00
PMCR- 2017/11/21
CRDT- 2016/12/24 06:00
PHST- 2016/08/05 00:00 [received]
PHST- 2016/12/10 00:00 [revised]
PHST- 2016/12/18 00:00 [accepted]
PHST- 2016/12/23 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
PHST- 2016/12/24 06:00 [entrez]
PHST- 2017/11/21 00:00 [pmc-release]
AID - S0378-4274(16)33356-2 [pii]
AID - 10.1016/j.toxlet.2016.12.013 [doi]
PST - ppublish
SO  - Toxicol Lett. 2017 Jan 15;266:49-55. doi: 10.1016/j.toxlet.2016.12.013. Epub 2016 
      Dec 19.