PMID- 28007792
OWN - NLM
STAT- MEDLINE
DCOM- 20180226
LR  - 20180618
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 49
IP  - 2
DP  - 2017 Feb
TI  - Association between sleep apnoea and pulmonary hypertension in Kyrgyz 
      highlanders.
LID - 1601530 [pii]
LID - 10.1183/13993003.01530-2016 [doi]
AB  - This case-control study evaluates a possible association between high altitude 
      pulmonary hypertension (HAPH) and sleep apnoea in people living at high 
      altitude.Ninety highlanders living at altitudes >2500 m without excessive 
      erythrocytosis and with normal spirometry were studied at 3250 m (Aksay, 
      Kyrgyzstan); 34 healthy lowlanders living below 800 m were studied at 760 m 
      (Bishkek, Kyrgyzstan). Echocardiography, polysomnography and other outcomes were 
      assessed. Thirty-six highlanders with elevated mean pulmonary artery pressure 
      (mPAP) >30 mmHg (31-42 mmHg by echocardiography) were designated as HAPH+. Their 
      data were compared to that of 54 healthy highlanders (HH, mPAP 13-28 mmHg) and 34 
      healthy lowlanders (LL, mPAP 8-24 mmHg).The HAPH+ group (median age 52 years 
      (interquartile range 47-59) had a higher apnoea-hypopnoea index (AHI) of 
      33.8 events.h(-1) (26.9-54.6) and spent a greater percentage of the night-time 
      with an oxygen saturation <90% (T<90; 78% (61-89)) than the HH group (median age 
      39 years (32-48), AHI 9.0 events.h(-1) (3.6-16), T<90 33% (10-69)) and the LL 
      group (median age 40 years (30-47), AHI 4.3 events.h(-1) (1.4-12.6), T<90 0% 
      (0-0)); p<0.007 for AHI and T<90, respectively, in HAPH+ versus others. In 
      highlanders, multivariable regression analysis confirmed an independent 
      association between mPAP and both AHI and T<90, when controlled for age, gender 
      and body mass index.Pulmonary hypertension in highlanders is associated with 
      sleep apnoea and hypoxaemia even when adjusted for age, gender and body mass 
      index, suggesting pathophysiologic interactions between pulmonary haemodynamics 
      and sleep apnoea.
CI  - Copyright (c)ERS 2017.
FAU - Latshang, Tsogyal D
AU  - Latshang TD
AD  - Clinic of Pneumology and Sleep Disorders Center, University Hospital Zurich, 
      Zurich, Switzerland.
FAU - Furian, Michael
AU  - Furian M
AD  - Clinic of Pneumology and Sleep Disorders Center, University Hospital Zurich, 
      Zurich, Switzerland.
FAU - Aeschbacher, Sayaka S
AU  - Aeschbacher SS
AD  - Clinic of Pneumology and Sleep Disorders Center, University Hospital Zurich, 
      Zurich, Switzerland.
FAU - Ulrich, Silvia
AU  - Ulrich S
AD  - Clinic of Pneumology and Sleep Disorders Center, University Hospital Zurich, 
      Zurich, Switzerland.
FAU - Osmonov, Batyr
AU  - Osmonov B
AD  - Dept of Respiratory, Critical Care and Sleep Medicine, National Center for 
      Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic.
FAU - Mirrakhimov, Erkin M
AU  - Mirrakhimov EM
AD  - Dept of Respiratory, Critical Care and Sleep Medicine, National Center for 
      Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic.
AD  - Kyrgyz State Medical Academy, Bishkek, Kyrgyz Republic.
FAU - Isakova, Jainagul
AU  - Isakova J
AD  - Research Institute for Molecular Biology and Medicine, Bishkek, Kyrgyz Republic.
FAU - Aldashev, Almaz A
AU  - Aldashev AA
AD  - Research Institute for Molecular Biology and Medicine, Bishkek, Kyrgyz Republic.
FAU - Sooronbaev, Talant M
AU  - Sooronbaev TM
AD  - Dept of Respiratory, Critical Care and Sleep Medicine, National Center for 
      Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic.
FAU - Bloch, Konrad E
AU  - Bloch KE
AD  - Clinic of Pneumology and Sleep Disorders Center, University Hospital Zurich, 
      Zurich, Switzerland konrad.bloch@usz.ch.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170202
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - Pulmonary edema of mountaineers
SB  - IM
CIN - Eur Respir J. 2017 Feb 2;49(2):. PMID: 28153872
MH  - Adult
MH  - Altitude
MH  - Altitude Sickness/*complications/*physiopathology
MH  - Blood Pressure
MH  - Case-Control Studies
MH  - Echocardiography, Doppler
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*complications/*physiopathology
MH  - Hypoxia/physiopathology
MH  - Kyrgyzstan
MH  - Lung/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Polysomnography
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Sleep Apnea Syndromes/*diagnosis/*physiopathology
MH  - Spirometry
MH  - Walk Test
EDAT- 2016/12/23 06:00
MHDA- 2018/02/27 06:00
CRDT- 2016/12/24 06:00
PHST- 2016/07/31 00:00 [received]
PHST- 2016/10/21 00:00 [accepted]
PHST- 2016/12/23 06:00 [pubmed]
PHST- 2018/02/27 06:00 [medline]
PHST- 2016/12/24 06:00 [entrez]
AID - 13993003.01530-2016 [pii]
AID - 10.1183/13993003.01530-2016 [doi]
PST - epublish
SO  - Eur Respir J. 2017 Feb 2;49(2):1601530. doi: 10.1183/13993003.01530-2016. Print 
      2017 Feb.