PMID- 28008516
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1432-2013 (Electronic)
IS  - 0031-6768 (Linking)
VI  - 440
IP  - Suppl 1
DP  - 2000 Jan
TI  - Nicardipine dose-dependently reduces the effect of equinatoxin II on coronary 
      flow in isolated porcine heart.
PG  - R145-R146
LID - 10.1007/s004240000040 [doi]
AB  - Death after i.v. administration of equinatoxin II (EqT II) has been attributed to 
      the circulatory failure resulting from cardiotoxic effects. The mechanism of 
      action is unknown. The aim of the present work was to study the effects of the 
      toxin on vascular tone in the isolated porcine coronary artery and on coronary 
      flow in the isolated pig heart. EqT II caused concentration-dependent 
      contractions of rings of the isolated epicardial porcine coronary artery with an 
      EC(50) value of 89+/-5 nM (n=5-6) and maximal effect of about 140% of the 
      contraction induced by 20 nM KCl. On Langendorff's porcine heart preparation EqT 
      II caused a dose-dependent decrease of coronary flow. At EqT II doses lower than 
      0.05 mumol/100 g of heart weight there were no measurable effects of the toxin. At 
      dose 0.5 mumol/100 g the toxin decreased coronary flow to less than 9.8+/-2.5 % of 
      the control value. The constrictory effect of the toxin on isolated porcine 
      coronary arteries was diminished by the L-type calcium channel antagonist 
      nicardipine (NC). NC in 1 muM concentration almost completely abolished the effect 
      of EqT II on coronary flow. Our results confirmed involvement of L-type calcium 
      channels in the vasoconstrictory effects of EqT II on epicardial coronary 
      arteries.
FAU - Drevensek, Gorazd
AU  - Drevensek G
AD  - Dept. of Pharmacol. & Exp. Toxicol., Korytkova 2,, Slovenia.
FAU - Budihna, Metka V
AU  - Budihna MV
AD  - Dept. of Pharmacol. & Exp. Toxicol., Korytkova 2,, Slovenia.
FAU - Suput, Dusan
AU  - Suput D
AD  - Department of Patophysiology, Zaloska 4, Faculty of Medicine, 1000 Ljubljana, 
      Slovenia, Slovenia.
FAU - Bunc, Matjaz
AU  - Bunc M
AD  - Department of Patophysiology, Zaloska 4, Faculty of Medicine, 1000 Ljubljana, 
      Slovenia, Slovenia.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pflugers Arch
JT  - Pflugers Archiv : European journal of physiology
JID - 0154720
OTO - NOTNLM
OT  - Key words equinatoxin II
OT  - coronary flow
OT  - isolated pig heart
OT  - isolated porcine coronary artery
OT  - nicardipine
EDAT- 2000/01/01 00:00
MHDA- 2000/01/01 00:01
CRDT- 2016/12/24 06:00
PHST- 2016/12/24 06:00 [entrez]
PHST- 2000/01/01 00:00 [pubmed]
PHST- 2000/01/01 00:01 [medline]
AID - 10.1007/s004240000040 [pii]
AID - 10.1007/s004240000040 [doi]
PST - ppublish
SO  - Pflugers Arch. 2000 Jan;440(Suppl 1):R145-R146. doi: 10.1007/s004240000040.