PMID- 28008656
OWN - NLM
STAT- MEDLINE
DCOM- 20180312
LR  - 20180312
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
VI  - 70
IP  - 7
DP  - 2017 Jun
TI  - Human herpesvirus 6 lymphadenitis in drug rash with eosinophilia and systemic 
      symptoms syndrome: a lymphoma mimic.
PG  - 1166-1170
LID - 10.1111/his.13157 [doi]
AB  - AIMS: Lymphadenopathy, haematological abnormalities and constitutional symptoms 
      are among the non-specific manifestations seen in drug rash with eosinophilia and 
      systemic symptoms (DRESS), an uncommon but potentially fatal cutaneous adverse 
      drug reaction. The ubiquitous human herpesvirus 6 (HHV-6) plays a unique role in 
      the pathogenesis of DRESS, with emerging data suggesting that reactivation occurs 
      in most cases and contributes to the clinical manifestations, including 
      lymphadenopathy. Further, in the appropriate clinical context, demonstration of 
      HHV-6 reactivation may lend support to a diagnosis of DRESS. The histopathology 
      of DRESS-associated HHV-6 lymphadenitis is reported rarely, with morphologic and 
      immunophenotypic characteristics concerning for T cell lymphoma. The aim is to 
      characterize the histopathology of HHV-6 lymphadenitis in the context of DRESS 
      and to highlight this as an important cause of lymphadenopathy that may be a 
      clinical, morphologic and immunophenotypic mimic of lymphoma. METHODS AND 
      RESULTS: We describe a case of lymphoma-mimicking lymphadenitis in which the 
      histopathological demonstration of reactivation of HHV-6 infection lent support 
      to the clinical diagnosis of DRESS. CONCLUSION: Lymph node biopsies concerning 
      for T cell lymphoma should be evaluated for HHV-6 involvement in a clinical 
      context suggestive of DRESS.
CI  - (c) 2016 John Wiley & Sons Ltd.
FAU - Johnson, Steven
AU  - Johnson S
AD  - Department of Pathology and Laboratory Medicine, The University of North Carolina 
      School of Medicine, Chapel Hill, NC, USA.
FAU - Mathews, Stephanie
AU  - Mathews S
AUID- ORCID: 0000-0001-8721-1633
AD  - Department of Pathology and Laboratory Medicine, The University of North Carolina 
      School of Medicine, Chapel Hill, NC, USA.
FAU - Hudnall, S David
AU  - Hudnall SD
AD  - Departments of Pathology and Laboratory Medicine, Yale University School of 
      Medicine, New Haven, CT, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170310
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - Drug Hypersensitivity Syndrome/*diagnosis/virology
MH  - Female
MH  - Herpesvirus 6, Human
MH  - Humans
MH  - Lymphadenitis/*virology
MH  - Lymphoma, T-Cell/*diagnosis
MH  - Roseolovirus Infections/*complications
OTO - NOTNLM
OT  - Drug rash with eosinophilia and systemic symptoms
OT  - T cell lymphoma
OT  - human herpesvirus 6
OT  - lymphadenopathy
EDAT- 2016/12/23 06:00
MHDA- 2018/03/13 06:00
CRDT- 2016/12/24 06:00
PHST- 2016/10/25 00:00 [received]
PHST- 2016/12/16 00:00 [revised]
PHST- 2016/12/20 00:00 [accepted]
PHST- 2016/12/23 06:00 [pubmed]
PHST- 2018/03/13 06:00 [medline]
PHST- 2016/12/24 06:00 [entrez]
AID - 10.1111/his.13157 [doi]
PST - ppublish
SO  - Histopathology. 2017 Jun;70(7):1166-1170. doi: 10.1111/his.13157. Epub 2017 Mar 
      10.