PMID- 28012210 OWN - NLM STAT- MEDLINE DCOM- 20180319 LR - 20180319 IS - 1540-8159 (Electronic) IS - 0147-8389 (Linking) VI - 40 IP - 5 DP - 2017 May TI - Elimination of Ventricular Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia by Targeting "Catecholamine-Sensitive Area": A Dominant-Subordinate Relationship between Origin Sites of Bidirectional Ventricular Premature Contractions. PG - 600-604 LID - 10.1111/pace.13006 [doi] AB - We report on a patient diagnosed with catechoaminergic polymorphic ventricular tachycardia (CPVT) who underwent catheter ablation of ventricular premature contractions (VPCs) induced by epinephrine. VPCs were classified roughly into three types. Type 1 and Type 2 VPCs (right bundle branch block [RBBB] configuration and inferior axis) were eliminated by radiofrequency applications at the left aortic sinus of Valsalva and the anterolateral papillary muscle (APM), respectively. Although no spontaneous VPCs were seen after the elimination of Type 1 and 2 VPCs, pacing resulting in capture at the APM induced Type 3 VPC (RBBB configuration and superior axis) reproducibly. The electrophysiological findings observed in our representative case have important implications both for understanding the pathophysiology of CPVT and for considering therapeutic strategies. CI - (c) 2016 Wiley Periodicals, Inc. FAU - Shirai, Yasuhiro AU - Shirai Y AD - Heart Rhythm Center, Tokyo Medical and Dental University Hospital, Tokyo, Japan. FAU - Goya, Masahiko AU - Goya M AD - Heart Rhythm Center, Tokyo Medical and Dental University Hospital, Tokyo, Japan. FAU - Ohno, Seiko AU - Ohno S AD - Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan. FAU - Horie, Minoru AU - Horie M AD - Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan. FAU - Doi, Shozaburo AU - Doi S AD - Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan. FAU - Isobe, Mitsuaki AU - Isobe M AD - Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan. FAU - Hirao, Kenzo AU - Hirao K AD - Heart Rhythm Center, Tokyo Medical and Dental University Hospital, Tokyo, Japan. LA - eng PT - Case Reports PT - Journal Article DEP - 20170214 PL - United States TA - Pacing Clin Electrophysiol JT - Pacing and clinical electrophysiology : PACE JID - 7803944 RN - Polymorphic catecholergic ventricular tachycardia SB - IM MH - Adult MH - Bundle-Branch Block/*complications/diagnosis/surgery MH - Catheter Ablation/*methods MH - Female MH - Heart Conduction System/surgery MH - Humans MH - Tachycardia, Ventricular/*complications/diagnosis/*surgery MH - Treatment Outcome MH - Ventricular Premature Complexes/*complications/diagnosis/*surgery OTO - NOTNLM OT - bidirectional ventricular premature contraction OT - catecholaminergic polymorphic ventricular tachycardia OT - catheter ablation EDAT- 2016/12/25 06:00 MHDA- 2018/03/20 06:00 CRDT- 2016/12/25 06:00 PHST- 2016/07/17 00:00 [received] PHST- 2016/11/14 00:00 [revised] PHST- 2016/12/04 00:00 [accepted] PHST- 2016/12/25 06:00 [pubmed] PHST- 2018/03/20 06:00 [medline] PHST- 2016/12/25 06:00 [entrez] AID - 10.1111/pace.13006 [doi] PST - ppublish SO - Pacing Clin Electrophysiol. 2017 May;40(5):600-604. doi: 10.1111/pace.13006. Epub 2017 Feb 14.