PMID- 28012807
OWN - NLM
STAT- MEDLINE
DCOM- 20171024
LR  - 20171024
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 17
DP  - 2017 Mar
TI  - Photodynamic inactivation of oral paracoccidioidomycosis affecting woman with 
      systemic lupus erythematosus: An unusual case report.
PG  - 160-163
LID - S1572-1000(16)30276-9 [pii]
LID - 10.1016/j.pdpdt.2016.12.006 [doi]
AB  - Paracoccidioidomycosis (PCM) is a systemic disease caused by the dimorphic fungus 
      Paracocdioides brasiliensis. The infection primarily reaches the lungs by the 
      inhalation of fungi spores and later can disseminate to other organs causing 
      secondary oral lesions. Systemic lupus erythematosus (SLE), on the other hand, is 
      an autoimmune chronic inflammatory disease that affects various organ systems, 
      including skin and oral cavity. Here we report a 39-year-old female patient 
      bearing SLE and presenting an ulcerated lesion on the hard palate extending to 
      the superior alveolar ridge, diagnosed as PCM. Itraconazole 200mg was prescribed 
      and photodynamic therapy (PDT) was also instituted in a way to help dealing with 
      the PCM infection while assisting such an immunocompromised patient to heal. PDT 
      consisted of topically placing toluidine blue dye at 37.5mg/L for 5min, followed 
      by low-level laser irradiation (660nm; 100J/cm(2); 40mW of power; 100s per 
      point). Forty days after beginning the treatment, the patient showed total 
      regression of the oral lesion and absence of painful symptoms. The serologic test 
      was performed again after six months of therapy and was negative; the patient 
      continues to be followed periodically.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Ribeiro, Cinthia Magalhaes
AU  - Ribeiro CM
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Rua Gabriel Monteiro da Silva, 700-Alfenas, MG, 37130-000, Brazil. 
      Electronic address: cinthiamribeiro@hotmail.com.
FAU - Caixeta, Clenivaldo Alves
AU  - Caixeta CA
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Rua Gabriel Monteiro da Silva, 700-Alfenas, MG, 37130-000, Brazil. 
      Electronic address: clenivaldodentista@yahoo.com.br.
FAU - de Carli, Marina Lara
AU  - de Carli ML
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Rua Gabriel Monteiro da Silva, 700-Alfenas, MG, 37130-000, Brazil. 
      Electronic address: marinadentista@gmail.com.
FAU - Sperandio, Felipe Fornias
AU  - Sperandio FF
AD  - Department of Pathology and Parasitology, Institute of Biomedical Sciences, 
      Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 700-Alfenas, MG, 
      37130-000, Brazil. Electronic address: ffsperandio@gmail.com.
FAU - de Sa Magalhaes, Evandro Monteiro
AU  - de Sa Magalhaes EM
AD  - Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 700-Alfenas, MG, 
      Brazil. Electronic address: monteiromagalhaes@oi.com.br.
FAU - Costa Pereira, Alessandro Antonio
AU  - Costa Pereira AA
AD  - Department of Pathology and Parasitology, Institute of Biomedical Sciences, 
      Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 700-Alfenas, MG, 
      37130-000, Brazil. Electronic address: alessandro.unifal@uol.com.br.
FAU - Costa Hanemann, Joao Adolfo
AU  - Costa Hanemann JA
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Rua Gabriel Monteiro da Silva, 700-Alfenas, MG, 37130-000, Brazil. 
      Electronic address: jachanemann@uol.com.br.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20161221
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Antifungal Agents)
RN  - 0 (Photosensitizing Agents)
RN  - 15XUH0X66N (Tolonium Chloride)
RN  - 304NUG5GF4 (Itraconazole)
SB  - IM
MH  - Adult
MH  - Antifungal Agents/therapeutic use
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Immunocompromised Host
MH  - Itraconazole/therapeutic use
MH  - Lupus Erythematosus, Systemic/epidemiology
MH  - Paracoccidioidomycosis/*drug therapy/epidemiology
MH  - Photochemotherapy/*methods
MH  - Photosensitizing Agents/*therapeutic use
MH  - Tolonium Chloride/*therapeutic use
OTO - NOTNLM
OT  - Antimicrobial
OT  - Paracoccidioides brasiliensis
OT  - Paracoccidioidomycosis
OT  - Photodynamic therapy
OT  - Systemic lupus erythematosus
OT  - Women
EDAT- 2016/12/26 06:00
MHDA- 2017/10/25 06:00
CRDT- 2016/12/26 06:00
PHST- 2016/11/30 00:00 [received]
PHST- 2016/12/14 00:00 [revised]
PHST- 2016/12/19 00:00 [accepted]
PHST- 2016/12/26 06:00 [pubmed]
PHST- 2017/10/25 06:00 [medline]
PHST- 2016/12/26 06:00 [entrez]
AID - S1572-1000(16)30276-9 [pii]
AID - 10.1016/j.pdpdt.2016.12.006 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2017 Mar;17:160-163. doi: 
      10.1016/j.pdpdt.2016.12.006. Epub 2016 Dec 21.