PMID- 28013432
OWN - NLM
STAT- MEDLINE
DCOM- 20170807
LR  - 20211204
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 36
IP  - 4
DP  - 2017 Apr
TI  - Association of human leukocyte A, B, and DR antigens in Colombian patients with 
      diagnosis of spondyloarthritis.
PG  - 953-958
LID - 10.1007/s10067-016-3516-2 [doi]
AB  - There is substantial evidence that non-B27 major histocompatibility complex (MHC) 
      genes are associated with spondyloarthritis (SpA). Studies in Mexican and 
      Tunisian populations demonstrated the association of SpA and human leukocyte 
      antigen (HLA) B15. The purpose of this study was to evaluate the association of 
      HLA-A, B, and DR antigens in a group of Colombian patients with a diagnosis of 
      SpA. A total of 189 patients and 100 healthy subjects were included in the 
      present study. All subjects underwent a complete characterization of HLA alleles 
      A, B, and DR. Of the 189 studied patients, 35 were reactive arthritis (ReA), 87 
      were ankylosing spondylitis (AS), and 67 undifferentiated SpA (uSpA). According 
      to the Assessment of Spondyloarthritis International Society (ASAS) criteria, 167 
      were axial SpA (axSpA) and 171 were peripheral SpA (pSpA). 63.8% were men, with a 
      mean age of 35.9 +/- 12.7 years. 40.7% (77/189) of patients were HLA-B27 positive 
      of which 52.9% had AS and 42.5% axSpA. 23.2% (44/189) of patients were HLA-B15 
      positive: 23.8% were uSpA, 12.57% were axSpA, and 11.7% were pSpA. In addition, 
      HLA-DRB1*01 was associated with AS (58.6%) and axSpA (42.5%). Also, HLA-DRB1*04 
      was present in 62 patients with AS (71.2%) and in 26 with axSpA (15.5%). In this 
      population, we found a strong association between the presence of HLA-B27 and the 
      diagnosis of axSpA and AS, but the HLA-B15 is also significantly associated with 
      all subtypes of the disease, predominantly with pSpA. Additionally, HLA-DR1 and 
      DR4 were associated in a cohort of patients with SpA from Colombia.
FAU - Santos, Ana M
AU  - Santos AM
AD  - Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 
      7, Autopista Norte de Bogota, Chia, Colombia.
FAU - Pena, Paola
AU  - Pena P
AD  - Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 
      7, Autopista Norte de Bogota, Chia, Colombia.
FAU - Avila, Mabel
AU  - Avila M
AD  - Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 
      7, Autopista Norte de Bogota, Chia, Colombia.
FAU - Briceno, Ignacio
AU  - Briceno I
AD  - Faculty of Medicine, Grupo Genetica Humana, Universidad de La Sabana, Chia, 
      Colombia.
FAU - Jaramillo, Carlos
AU  - Jaramillo C
AD  - Department of Biological Sciences, Universidad de Los Andes, Bogota, Colombia.
FAU - Vargas-Alarcon, Gilberto
AU  - Vargas-Alarcon G
AD  - Interventional Genetic Study Group in Cardiovascular Diseases, Department of 
      Molecular Biology, National Institute of Cardiology Ignacio Chavez, Mexico, DF, 
      Mexico.
FAU - Rueda, Juan C
AU  - Rueda JC
AD  - Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 
      7, Autopista Norte de Bogota, Chia, Colombia.
FAU - Saldarriaga, Eugenia-Lucia
AU  - Saldarriaga EL
AD  - Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 
      7, Autopista Norte de Bogota, Chia, Colombia.
FAU - Angarita, Jose-Ignacio
AU  - Angarita JI
AD  - Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 
      7, Autopista Norte de Bogota, Chia, Colombia.
FAU - Martinez-Rodriguez, Nancy
AU  - Martinez-Rodriguez N
AD  - Community Health Research Department, Ministry of Health (SSA), Hospital Infantil 
      de Mexico Federico Gomez, Mexico, DF, Mexico.
FAU - Londono, John
AU  - Londono J
AD  - Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 
      7, Autopista Norte de Bogota, Chia, Colombia. john.londono@unisabana.edu.co.
LA  - eng
PT  - Journal Article
DEP - 20161224
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (HLA-B15 Antigen)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (PHB2 protein, human)
RN  - 0 (Prohibitins)
SB  - IM
MH  - Adult
MH  - Arthritis, Reactive/diagnosis/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - HLA-B15 Antigen/*genetics
MH  - HLA-B27 Antigen/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Mexico
MH  - Middle Aged
MH  - Prohibitins
MH  - Spondylitis, Ankylosing/diagnosis/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Allele frequency
OT  - Colombia
OT  - Genetics
OT  - HLA-B15
OT  - Humans
OT  - Spondyloarthritis
EDAT- 2016/12/26 06:00
MHDA- 2017/08/08 06:00
CRDT- 2016/12/26 06:00
PHST- 2016/11/15 00:00 [received]
PHST- 2016/12/11 00:00 [accepted]
PHST- 2016/12/26 06:00 [pubmed]
PHST- 2017/08/08 06:00 [medline]
PHST- 2016/12/26 06:00 [entrez]
AID - 10.1007/s10067-016-3516-2 [pii]
AID - 10.1007/s10067-016-3516-2 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2017 Apr;36(4):953-958. doi: 10.1007/s10067-016-3516-2. Epub 2016 
      Dec 24.