PMID- 28017218
OWN - NLM
STAT- MEDLINE
DCOM- 20170530
LR  - 20191210
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 372
DP  - 2017 Jan 15
TI  - Clinical characteristics, and impairment and disability scale scores for 
      different CIDP Disease Activity Status classes.
PG  - 223-227
LID - S0022-510X(16)30759-6 [pii]
LID - 10.1016/j.jns.2016.11.056 [doi]
AB  - INTRODUCTION: Selecting proper outcome measures is important for clinical 
      practice and clinical studies assessing treatable neuropathies, such as chronic 
      inflammatory demyelinating polyneuropathy (CIDP). OBJECTIVES: To explore clinical 
      characteristics and impairment and disability scores in CIDP patients, and assess 
      their relationship to different CIDP Disease Activity Status (CDAS) classes. 
      METHODS: We performed a retrospective chart review of CIDP patients attending the 
      neuromuscular clinic between January 2014 and December 2015, and explored 
      clinical characteristics, and various impairment and disability scores for 
      different CDAS classes. RESULTS: The total cohort included 69 CIDP patients. A 
      higher CDAS class was correlated with more frequent motor and sensory deficits, 
      worse sensory sum score, worse scores on the disability scales, including the 
      Rasch-built overall disability scale (RODS) and Overall Neuropathy Limitation 
      Scale (ONLS), and lower treatment responsiveness. ONLS and RODS scales were 
      significantly correlated (r=-0.86, p<0.0001). A change of one point or more in 
      the ONLS score, was associated with a corresponding change of 4.1-4.5 points in 
      the RODS score. DISCUSSION: The study results show that a higher CDAS class is 
      correlated with a more severe neuropathy. This was reflected by the sensory sum 
      score, RODS and ONLS. These results might help profile CIDP patients at different 
      CDAS classes for clinical practice and future clinical studies.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Alabdali, Majed
AU  - Alabdali M
AD  - Department of Neurology, King Fahad Hospital of the University, University of 
      Dammam, Dammam, Saudi Arabia.
FAU - Abraham, Alon
AU  - Abraham A
AD  - Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of 
      Neurology, Department of Medicine, University Health Network, University of 
      Toronto, Toronto, Canada.
FAU - Alsulaiman, Abdulla
AU  - Alsulaiman A
AD  - Department of Neurology, King Fahad Hospital of the University, University of 
      Dammam, Dammam, Saudi Arabia.
FAU - Breiner, Ari
AU  - Breiner A
AD  - Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of 
      Neurology, Department of Medicine, University Health Network, University of 
      Toronto, Toronto, Canada.
FAU - Barnett, Carolina
AU  - Barnett C
AD  - Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of 
      Neurology, Department of Medicine, University Health Network, University of 
      Toronto, Toronto, Canada.
FAU - Katzberg, Hans D
AU  - Katzberg HD
AD  - Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of 
      Neurology, Department of Medicine, University Health Network, University of 
      Toronto, Toronto, Canada.
FAU - Lovblom, Leif E
AU  - Lovblom LE
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai, 
      Hospital and Lunenfeld Tanenbaum Research Institute, University of Toronto, 
      Toronto, Canada.
FAU - Perkins, Bruce A
AU  - Perkins BA
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai, 
      Hospital and Lunenfeld Tanenbaum Research Institute, University of Toronto, 
      Toronto, Canada.
FAU - Bril, Vera
AU  - Bril V
AD  - Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of 
      Neurology, Department of Medicine, University Health Network, University of 
      Toronto, Toronto, Canada. Electronic address: vera.bril@utoronto.ca.
LA  - eng
PT  - Journal Article
DEP - 20161123
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - Aged
MH  - *Disabled Persons
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neural Conduction/physiology
MH  - Outcome Assessment, Health Care
MH  - Polyradiculoneuropathy, Chronic Inflammatory 
      Demyelinating/*complications/*diagnosis
MH  - Retrospective Studies
MH  - Sensory Thresholds/*physiology
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Vibration
OTO - NOTNLM
OT  - CDAS
OT  - CIDP
OT  - MRC sum score
OT  - ONLS
OT  - RODS
EDAT- 2016/12/27 06:00
MHDA- 2017/05/31 06:00
CRDT- 2016/12/27 06:00
PHST- 2016/09/15 00:00 [received]
PHST- 2016/10/26 00:00 [revised]
PHST- 2016/11/22 00:00 [accepted]
PHST- 2016/12/27 06:00 [entrez]
PHST- 2016/12/27 06:00 [pubmed]
PHST- 2017/05/31 06:00 [medline]
AID - S0022-510X(16)30759-6 [pii]
AID - 10.1016/j.jns.2016.11.056 [doi]
PST - ppublish
SO  - J Neurol Sci. 2017 Jan 15;372:223-227. doi: 10.1016/j.jns.2016.11.056. Epub 2016 
      Nov 23.