PMID- 28017348
OWN - NLM
STAT- MEDLINE
DCOM- 20180302
LR  - 20210109
IS  - 2213-1787 (Electronic)
IS  - 2213-1779 (Linking)
VI  - 5
IP  - 1
DP  - 2017 Jan
TI  - Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or 
      Sudden Death in Dilated Cardiomyopathy: Systematic Review and Meta-Analysis.
PG  - 28-38
LID - S2213-1779(16)30569-8 [pii]
LID - 10.1016/j.jchf.2016.09.017 [doi]
AB  - OBJECTIVES: The aim of this study was to evaluate the association between late 
      gadolinium enhancement (LGE) on cardiac magnetic resonance imaging and 
      ventricular arrhythmias or sudden cardiac death (SCD) in patients with dilated 
      cardiomyopathy (DCM). BACKGROUND: Risk stratification for SCD in DCM needs to be 
      improved. METHODS: A systematic review and meta-analysis were conducted. A 
      systematic search of PubMed and Ovid was performed, and observational studies 
      that analyzed the arrhythmic endpoint (sustained ventricular arrhythmia, 
      appropriate implantable cardioverter-defibrillator [ICD] therapy, or SCD) in 
      patients with DCM, stratified by the presence or absence of LGE, were included. 
      RESULTS: Twenty-nine studies were included, accounting for 2,948 patients. The 
      studies covered a wide spectrum of DCM, with a mean left ventricular ejection 
      fraction between 20% and 43%. LGE was significantly associated with the 
      arrhythmic endpoint both in the overall population (odds ratio: 4.3; p < 0.001) 
      and when including only those studies that performed multivariate analysis 
      (hazard ratio: 6.7; p < 0.001). The association between LGE and the arrhythmic 
      endpoint remained significant among studies with mean left ventricular ejection 
      fractions >35% (odds ratio: 5.2; p < 0.001) and was maximal in studies that 
      included only patients with primary prevention ICDs (odds ratio: 7.8; p = 0.008). 
      CONCLUSIONS: Across a wide spectrum of patients with DCM, LGE is strongly and 
      independently associated with ventricular arrhythmia or SCD. LGE could be a 
      powerful tool to improve risk stratification for SCD in patients with DCM. These 
      results raise 2 major questions to be addressed in future studies: whether 
      patients with LGE could benefit from primary prevention ICDs irrespective of 
      their left ventricular ejection fractions, while patients without LGE might not 
      need preventive ICDs despite having severe left ventricular dysfunction.
CI  - Copyright (c) 2017 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Di Marco, Andrea
AU  - Di Marco A
AD  - Arrhythmia Unit, Heart Disease Institute, Bellvitge University Hospital, 
      Barcelona, Spain. Electronic address: ayfanciu@hotmail.com.
FAU - Anguera, Ignasi
AU  - Anguera I
AD  - Arrhythmia Unit, Heart Disease Institute, Bellvitge University Hospital, 
      Barcelona, Spain.
FAU - Schmitt, Matthias
AU  - Schmitt M
AD  - University Hospital of South Manchester, United Kingdom.
FAU - Klem, Igor
AU  - Klem I
AD  - Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, 
      Durham, North Carolina.
FAU - Neilan, Tomas G
AU  - Neilan TG
AD  - Division of Cardiology and Cardiac MR PET CT Program, Massachusetts General 
      Hospital, Boston, Massachusetts.
FAU - White, James A
AU  - White JA
AD  - Stephenson CMR Centre at the Libin Cardiovascular Institute of Alberta, Calgary, 
      Alberta, Canada.
FAU - Sramko, Marek
AU  - Sramko M
AD  - Department of Cardiology, Institute for Clinical and Experimental Medicine, 
      Prague, Czech Republic.
FAU - Masci, Pier Giorgio
AU  - Masci PG
AD  - Centre for Cardiovascular Magnetic Resonance, Lausanne University Hospital, 
      Lausanne, Switzerland.
FAU - Barison, Andrea
AU  - Barison A
AD  - Fondazione "G. Monasterio," CNR-Regione Toscana, Pisa, Italy.
FAU - Mckenna, Peter
AU  - Mckenna P
AD  - FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.
FAU - Mordi, Ify
AU  - Mordi I
AD  - BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and 
      Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
FAU - Haugaa, Kristina H
AU  - Haugaa KH
AD  - Department of Cardiology, Oslo University Hospital, Oslo, Norway.
FAU - Leyva, Francisco
AU  - Leyva F
AD  - Department of Cardiology, The Queen Elizabeth Hospital, Birmingham, United 
      Kingdom.
FAU - Rodriguez Capitan, Jorge
AU  - Rodriguez Capitan J
AD  - Antequera Hospital, Malaga, Spain.
FAU - Satoh, Hiroshi
AU  - Satoh H
AD  - Division of Cardiology, Internal Medicine III, Hamamatsu University Hospital, 
      Hamamatsu, Japan.
FAU - Nabeta, Takeru
AU  - Nabeta T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Tokyo, Japan.
FAU - Dallaglio, Paolo Domenico
AU  - Dallaglio PD
AD  - Arrhythmia Unit, Heart Disease Institute, Bellvitge University Hospital, 
      Barcelona, Spain.
FAU - Campbell, Niall G
AU  - Campbell NG
AD  - University Hospital of South Manchester, United Kingdom.
FAU - Sabate, Xavier
AU  - Sabate X
AD  - Arrhythmia Unit, Heart Disease Institute, Bellvitge University Hospital, 
      Barcelona, Spain.
FAU - Cequier, Angel
AU  - Cequier A
AD  - Arrhythmia Unit, Heart Disease Institute, Bellvitge University Hospital, 
      Barcelona, Spain.
LA  - eng
GR  - PCL/17/07/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20161221
PL  - United States
TA  - JACC Heart Fail
JT  - JACC. Heart failure
JID - 101598241
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - JACC Heart Fail. 2017 Jan;5(1):39-43. PMID: 28034375
EIN - JACC Heart Fail. 2017 Apr;5(4):316. PMID: 28359423
CIN - JACC Heart Fail. 2017 May;5(5):394. PMID: 28449801
CIN - JACC Heart Fail. 2017 May;5(5):394-395. PMID: 28449802
MH  - Arrhythmias, Cardiac/*etiology
MH  - Cardiomyopathy, Dilated/complications/*diagnostic imaging
MH  - *Contrast Media
MH  - Death, Sudden, Cardiac/*etiology
MH  - *Gadolinium
MH  - Humans
MH  - *Magnetic Resonance Imaging
OTO - NOTNLM
OT  - cardiac magnetic resonance
OT  - dilated cardiomyopathy
OT  - late gadolinium enhancement
OT  - sudden death
OT  - ventricular arrhythmias
EDAT- 2016/12/27 06:00
MHDA- 2018/03/03 06:00
CRDT- 2016/12/27 06:00
PHST- 2016/09/09 00:00 [received]
PHST- 2016/09/29 00:00 [accepted]
PHST- 2016/12/27 06:00 [pubmed]
PHST- 2018/03/03 06:00 [medline]
PHST- 2016/12/27 06:00 [entrez]
AID - S2213-1779(16)30569-8 [pii]
AID - 10.1016/j.jchf.2016.09.017 [doi]
PST - ppublish
SO  - JACC Heart Fail. 2017 Jan;5(1):28-38. doi: 10.1016/j.jchf.2016.09.017. Epub 2016 
      Dec 21.