PMID- 2801857
OWN - NLM
STAT- MEDLINE
DCOM- 19891109
LR  - 20190627
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 108
IP  - 4
DP  - 1989 Oct 15
TI  - An association between acute retinal necrosis syndrome and HLA-DQw7 and phenotype 
      Bw62, DR4.
PG  - 370-4
AB  - Human leukocyte antigen (HLA) typing was performed on 27 white patients with 
      acute retinal necrosis syndrome. Antigens for the HLA-A, -B, -C, -DR and -DQ loci 
      were determined, and frequencies were compared with racially matched controls. 
      There was a statistically significant increase in the frequency of HLA-DQw7 (11 
      of 20 [55%] of patients vs 294 of 1546 [19%] of controls, P = .0004, relative 
      risk 5.20) that remained significant at the P = .05 level when the P value was 
      multiplied by the number of antigens tested. The HLA phenotype Bw62, DR4 is also 
      more frequent than in normal control populations (4 of 25 [16%] of patients vs 26 
      of 1023 [2.6%] of controls, relative risk 7.49). These results support an 
      association between the acute retinal necrosis syndrome and certain HLA 
      specificities and suggest a possible immunogenetic predisposition to the syndrome 
      in some patients.
FAU - Holland, G N
AU  - Holland GN
AD  - Jules Stein Eye Institute, Department of Ophthalmology, UCLA School of Medicine.
FAU - Cornell, P J
AU  - Cornell PJ
FAU - Park, M S
AU  - Park MS
FAU - Barbetti, A
AU  - Barbetti A
FAU - Yuge, J
AU  - Yuge J
FAU - Kreiger, A E
AU  - Kreiger AE
FAU - Kaplan, H J
AU  - Kaplan HJ
FAU - Pepose, J S
AU  - Pepose JS
FAU - Heckenlively, J R
AU  - Heckenlively JR
FAU - Culbertson, W W
AU  - Culbertson WW
AU  - et al.
LA  - eng
GR  - DK02375/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B15 Antigen)
RN  - 0 (HLA-Bw62)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - Female
MH  - HLA-B Antigens
MH  - HLA-B15 Antigen
MH  - HLA-DQ Antigens/*analysis
MH  - HLA-DR4 Antigen/*analysis
MH  - Humans
MH  - Male
MH  - Phenotype
MH  - Reference Values
MH  - Retinal Necrosis Syndrome, Acute/genetics/*immunology
EDAT- 1989/10/15 00:00
MHDA- 1989/10/15 00:01
CRDT- 1989/10/15 00:00
PHST- 1989/10/15 00:00 [pubmed]
PHST- 1989/10/15 00:01 [medline]
PHST- 1989/10/15 00:00 [entrez]
AID - S0002-9394(14)73303-3 [pii]
AID - 10.1016/s0002-9394(14)73303-3 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 1989 Oct 15;108(4):370-4. doi: 10.1016/s0002-9394(14)73303-3.