PMID- 28019103 OWN - NLM STAT- MEDLINE DCOM- 20180511 LR - 20191210 IS - 1479-9731 (Electronic) IS - 1479-9723 (Print) IS - 1479-9723 (Linking) VI - 14 IP - 2 DP - 2017 May TI - Translation and validation of the King's Brief Interstitial Lung Disease (K-BILD) questionnaire in French, Italian, Swedish, and Dutch. PG - 140-150 LID - 10.1177/1479972316674425 [doi] AB - No disease-specific instruments exist in Dutch, French, Italian, and Swedish to measure health status in idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILDs). The King's Brief Interstitial Lung Disease (K-BILD) is a 15-item validated questionnaire assessing health status in patients with ILD. The aim of this study was to translate and validate the K-BILD to French, Italian, Swedish, and Dutch versions. The K-BILD was translated following a forward-backward multistep procedure and tested in structured patient interviews. Subsequently, 195 outpatients with ILD were asked to complete K-BILD, St. George's Respiratory Questionnaire (SGRQ), and Euroqol EQ-5D-5L (EQ5D), twice, 2 weeks apart. Internal consistency, concurrent validity, and repeatability were determined. No major difficulties occurred in the translation processes. The K-BILD was considered comprehensible and relevant by patients. One hundred seventy-six patients (108 IPF and 68 other ILDs) completed the translated K-BILD. Internal consistency was good for all K-BILD modules (Cronbach's alpha 0.70-0.93). Concurrent validity of K-BILD was strong compared with SGRQ ( r = -0.86) and EQ5D ( r = 0.68), low with transfer capacity of the lung for carbon monoxide corrected for hemoglobin ( r = 0.33) and with forced vital capacity ( r = 0.35). The K-BILD and its domains were repeatable over 2 weeks; intraclass correlation coefficients were 0.86-0.93 ( n = 159). Known groups validity showed K-BILD was able to discriminate between patients based on severity of disease. K-BILD's validity and reliability for patients with IPF was similar to that of other ILDs. The French, Italian, Swedish, and Dutch translated K-BILD questionnaires were well-received by patients and demonstrated excellent validity comparable to the original English K-BILD. FAU - Wapenaar, Monique AU - Wapenaar M AD - 1 Department of Pulmonary Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. FAU - Patel, Amit S AU - Patel AS AD - 2 Department of Respiratory Medicine, King's College Hospital, London, UK. FAU - Birring, Surinder S AU - Birring SS AD - 3 Division of Asthma, Allergy and Lung Biology, King's College London, London, UK. FAU - Domburg, Ron T van AU - Domburg RTV AD - 4 Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands. FAU - Bakker, Eric Wp AU - Bakker EW AD - 5 Division Clinical Methods and Public Health, Academic Medical Center, University of Amsterdam, the Netherlands. FAU - Vindigni, Virginia AU - Vindigni V AD - 6 Department of Clinical and Experimental Medicine, University of Catania, Italy. FAU - Skold, C Magnus AU - Skold CM AD - 7 Karolinska Institute, Department of Medicine Solna and Centre for Molecular Medicine, Respiratory Medicine Unit, Karolinska University Hospital, Solna, Stockholm, Sweden. FAU - Cottin, Vincent AU - Cottin V AD - 8 Department of Respiratory Medicine, Louis Pradel Hospital, Lyon 1 University, Lyon, France. FAU - Vancheri, Carlo AU - Vancheri C AD - 6 Department of Clinical and Experimental Medicine, University of Catania, Italy. FAU - Wijsenbeek, Marlies S AU - Wijsenbeek MS AD - 1 Department of Pulmonary Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. LA - eng PT - Journal Article PT - Validation Study DEP - 20161226 PL - England TA - Chron Respir Dis JT - Chronic respiratory disease JID - 101197408 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - *Health Status MH - Humans MH - *Idiopathic Pulmonary Fibrosis/complications MH - Language MH - Male MH - Middle Aged MH - Psychometrics MH - *Quality of Life MH - Reproducibility of Results MH - *Surveys and Questionnaires MH - Translating PMC - PMC5720224 OTO - NOTNLM OT - Interstitial lung diseases OT - health status OT - idiopathic pulmonary fibrosis OT - quality of life OT - questionnaires COIS- Declaration of conflicting interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Monique Wapenaar (MSc), Dr Patel, Dr Birring, Dr van Domburg, Dr Bakker, Dr Vindigni, and Prof. Vancheri have no conflicts of interest. Prof. Skold has received honoraria for consulting, advisory boards, and lectures from AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Meda, Novartis, Mundipharma, Sandoz, Chiesi, Almirall, Intermune, and Roche, and research grants from Boehringer Ingelheim, Roche, and Sandoz. Prof. Cottin has received honoraria for consulting or participating to advisory board meetings, for speaking, and support for attending meetings from GSK, Intermune/Roche, Novartis, Sanofi, Biogen Idec., Actelion, Bayer, Boehringer Ingelheim, and Gilead. Dr Wijsenbeek has received honoraria for consulting or participating to advisory board meeting or speaking of Boehringer Ingelheim and Intermune/Roche, she received unrestricted research grants from Intermune, Hoffman la Roche, and Boehringer Ingelheim. All honoraria were paid to her institution. EDAT- 2016/12/27 06:00 MHDA- 2018/05/12 06:00 PMCR- 2017/05/01 CRDT- 2016/12/27 06:00 PHST- 2016/12/27 06:00 [pubmed] PHST- 2018/05/12 06:00 [medline] PHST- 2016/12/27 06:00 [entrez] PHST- 2017/05/01 00:00 [pmc-release] AID - 10.1177_1479972316674425 [pii] AID - 10.1177/1479972316674425 [doi] PST - ppublish SO - Chron Respir Dis. 2017 May;14(2):140-150. doi: 10.1177/1479972316674425. Epub 2016 Dec 26.