PMID- 2802000
OWN - NLM
STAT- MEDLINE
DCOM- 19891117
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 257
IP  - 4 Pt 2
DP  - 1989 Oct
TI  - Intrapreoptically microdialyzed and microinjected norepinephrine evokes different 
      thermal responses.
PG  - R816-21
AB  - Norepinephrine (NE) microdialyzed into the medial preoptic area (MPO) evokes a 
      core temperature (Tco) fall in contrast to the rise when it is microinjected. 
      Because prostaglandin E2 (PGE2) is a contaminant of the microinjection procedure 
      per se, we determined whether it might account for these differential thermal 
      responses. NE (1 microgram/microliter) was bilaterally microinjected into the MPO 
      of conscious guinea pigs treated 20 min prior with a PG synthetase inhibitor, 
      indomethacin (Indo, 10 mg/kg, im). Under these conditions, the latency of the 
      NE-induced Tco rise was prolonged (138 +/- 18 min). When Indo was administered 
      both 20 min before and 20 min after NE microinjection, NE was hypothermizing. NE 
      (10 micrograms/microliter at 2 microliters/min for 3 h) microdialyzed into the 
      MPO, lateral septum, or anterior hypothalamus caused Tco falls, whereas it 
      induced no Tco change when dialyzed into the lateral preoptic area, indicating 
      site specificity. PGE2 (1 microgram/microliter) caused a Tco rise when it was 
      dialyzed intra-MPO. Microdialysis of PGE2 and NE together neutralized each 
      other's effects. Indo given at the end of intra-MPO NE dialysis blocked the usual 
      recovery of Tco from its lowered value. These results indicate that NE and PGE2 
      in the MPO may reciprocally influence the Tco of guinea pigs. The data further 
      suggest that PGE may account for the different responses to microinjected and 
      microdialyzed NE.
FAU - Quan, N
AU  - Quan N
AD  - Department of Physiology and Biophysics, University of Tennessee, Memphis 38163.
FAU - Blatteis, C M
AU  - Blatteis CM
LA  - eng
GR  - NS 22716/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - K7Q1JQR04M (Dinoprostone)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Animals
MH  - Body Temperature/*drug effects
MH  - Body Temperature Regulation/*drug effects
MH  - Dialysis
MH  - Dinoprostone/pharmacology
MH  - Guinea Pigs
MH  - Indomethacin/pharmacology
MH  - Male
MH  - Microinjections
MH  - Norepinephrine/administration & dosage/*pharmacology
MH  - Preoptic Area/drug effects/*physiology
EDAT- 1989/10/01 00:00
MHDA- 1989/10/01 00:01
CRDT- 1989/10/01 00:00
PHST- 1989/10/01 00:00 [pubmed]
PHST- 1989/10/01 00:01 [medline]
PHST- 1989/10/01 00:00 [entrez]
AID - 10.1152/ajpregu.1989.257.4.R816 [doi]
PST - ppublish
SO  - Am J Physiol. 1989 Oct;257(4 Pt 2):R816-21. doi: 10.1152/ajpregu.1989.257.4.R816.