PMID- 28024507
OWN - NLM
STAT- MEDLINE
DCOM- 20180628
LR  - 20181023
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 24
IP  - 6
DP  - 2016 Dec
TI  - [Correlation of Thrombosis and Prothrombotic State with Coagulation Factor V Gene 
      Polymorphism and APCR. HHcy].
PG  - 1850-1855
LID - 10.7534/j.issn.1009-2137.2016.06.043 [doi]
AB  - OBJECTIVE: To investigate the correlation of patients with thrombosis or 
      prothrombotic status with hyperhomocysteinemia (HHcy), activated protein 
      C-resistance(APCR) and gene polymorphism of coagulation factor V. METHODS: Three 
      hundred healthy voluteers were selected as controls, 223 cases of thrombosis (80 
      cases of cerebral infarction of CT, the MI of 82 cases of myocardial infarction, 
      venous thrombosis of VTE 61 cases), 270 cases of patients with prothrombotic 
      state (76 cases of pregnancy disease of PIH, 62 cases of chronic obstructive 
      pulmonary disease (COPD), 60 cases of diabetes(DM) and 72 cases of cancer) were 
      enrolled in this study. The plasma APCR and hyperhomocysteinemia were detected by 
      APTT coagulation method and cycling enzyme method respectively, and restriction 
      fragment length polymorphism(RFLP) were was used to detect the gene polymorphism 
      of FV G1691-A, G1091-C and A1090-G in the patient and control groups. RESULTS: 
      APCR positive rate was 62.29% and 7.33%, and the positive hyperhomocysteinemia 
      accounted for 68.42% and 10.00% respectively in the group of the patients with 
      venous thrombosis and the normal control group. 3 cases of heterozygous FV gene 
      mutations were found in the APCR-positive patients with venous thrombosis. 
      CONCLUSION: HHcy possitive rate of patients with venous thrombosis is 
      signiticantly higher than that in control, the HHcy is one of the important 
      causes resulting in thrombosis, the patients with venous thrombosis have proved 
      to be with APCR, and the possitive APCR may be related with the coagulation 
      factor V gene polymorphism.
FAU - Gao, Li-Xia
AU  - Gao LX
AD  - Department of Hematology and Oncology, Karamay Central Hospital, Karamay 834000, 
      Xingjiang Uygur Autonomous Region, China. E-mail: gaolixia2006m@163.com.
FAU - Ding, Qiu-Lan
AU  - Ding QL
AD  - Department of Laboratorial Examination, Ruijin Hospital, Shanghai Jiaotong 
      University, Shanghai 200050, China.
FAU - Wu, Ke-Xiong
AU  - Wu KX
AD  - Department of Hematology and Oncology, Karamay Central Hospital, Karamay 834000, 
      Xingjiang Uygur Autonomous Region, China.
FAU - Hu, Jun
AU  - Hu J
AD  - Department of Hematology and Oncology, Karamay Central Hospital, Karamay 834000, 
      Xingjiang Uygur Autonomous Region, China.
FAU - Wang, Xue-Feng
AU  - Wang XF
AD  - Department of Laboratorial Examination, Ruijin Hospital, Shanghai Jiaotong 
      University, Shanghai 200050, China.
FAU - Dong, Chuan-Ling
AU  - Dong CL
AD  - Department of Hematology and Oncology, Karamay Central Hospital, Karamay 834000, 
      Xingjiang Uygur Autonomous Region, China.
FAU - Dai, Qin
AU  - Dai Q
AD  - Department of Laboratorial Examination, Ruijin Hospital, Shanghai Jiaotong 
      University, Shanghai 200050, China.
FAU - Zhang, Bing
AU  - Zhang B
AD  - Department of Hematology and Oncology, Karamay Central Hospital, Karamay 834000, 
      Xingjiang Uygur Autonomous Region, China.
FAU - Dai, Jin
AU  - Dai J
AD  - Department of Hematology and Oncology, Karamay Central Hospital, Karamay 834000, 
      Xingjiang Uygur Autonomous Region, China.
FAU - He, Ping
AU  - He P
AD  - Department of Hematology and Oncology, Karamay Central Hospital, Karamay 834000, 
      Xingjiang Uygur Autonomous Region, China.
FAU - Zhang, Xue-Ping
AU  - Zhang XP
AD  - Department of Laboratorial Examination, Karamay Central Hospital, Karamay 834000, 
      Xingjiang Uygur Autonomous Region, China.
FAU - Wang, Yun-Xia
AU  - Wang YX
AD  - Xinjiang Urumqi Center for Disease Control and Prevention, Urumqi 830000, 
      Xingjiang Uygur Autonomous Region, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 9001-24-5 (Factor V)
SB  - IM
MH  - Activated Protein C Resistance
MH  - Factor V
MH  - Female
MH  - Humans
MH  - Mutation
MH  - *Polymorphism, Genetic
MH  - Pregnancy
MH  - Thrombosis
MH  - Venous Thrombosis
EDAT- 2016/12/28 06:00
MHDA- 2018/06/29 06:00
CRDT- 2016/12/28 06:00
PHST- 2016/12/28 06:00 [entrez]
PHST- 2016/12/28 06:00 [pubmed]
PHST- 2018/06/29 06:00 [medline]
AID - 1009-2137(2016)06-1850-06 [pii]
AID - 10.7534/j.issn.1009-2137.2016.06.043 [doi]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Dec;24(6):1850-1855. doi: 
      10.7534/j.issn.1009-2137.2016.06.043.