PMID- 28025461
OWN - NLM
STAT- MEDLINE
DCOM- 20170310
LR  - 20170310
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 81
IP  - 3
DP  - 2017 Feb 24
TI  - Biphasic Force-Frequency Relation Predicts Primary Cardiac Events in Patients 
      With Hypertrophic Cardiomyopathy.
PG  - 368-375
LID - 10.1253/circj.CJ-16-1007 [doi]
AB  - BACKGROUND: The force-frequency relation (FFR) is a hemodynamic index of the 
      chronotropic relationship between left ventricular (LV) systolic function 
      (percent change in dP/dt(max)) and elevation of heart rate. FFR is a marker of 
      myocardial contractile reserve and follows an upward slope in healthy myocardium 
      [monophasic FFR (MoF)], a pattern that becomes biphasic (BiF) under pathological 
      conditions. However, it remains uncertain whether the FFR determines a patient's 
      prognosis. We investigated the promising role of the FFR as a predictor of 
      cardiac events in the setting of hypertrophic cardiomyopathy 
      (HCM).Methods and Results:A total of 113 consecutive patients with HCM (New York 
      Heart Association (NYHA) class I-II) were retrospectively evaluated; 27 (23.9%) 
      had a BiF pattern and they experienced a higher incidence of cardiac events 
      compared with those showing an MoF pattern (median follow-up, 4.7 years; 
      P<0.001). Furthermore, Cox proportional hazard regression analysis revealed that 
      the LV end-diastolic volume index (hazard ratio: 1.051, P=0.014) and BiF pattern 
      (hazard ratio: 15.260, P=0.001) were independent predictors of primary cardiac 
      events. Interestingly, abnormal reductions in myocardial regulatory molecules 
      related to contractility (SERCA2alpha) were observed exclusively in the patients 
      exhibiting a BiF pattern. CONCLUSIONS: The FFR reflects latent myocardial 
      abnormalities and predicts cardiac events in the setting of HCM, even during the 
      asymptomatic stages of the disease.
FAU - Morimoto, Ryota
AU  - Morimoto R
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine.
FAU - Okumura, Takahiro
AU  - Okumura T
FAU - Bando, Yasuko K
AU  - Bando YK
FAU - Fukaya, Kenji
AU  - Fukaya K
FAU - Sawamura, Akinori
AU  - Sawamura A
FAU - Kawase, Haruya
AU  - Kawase H
FAU - Shimizu, Shinya
AU  - Shimizu S
FAU - Shimazu, Shuzo
AU  - Shimazu S
FAU - Hirashiki, Akihiro
AU  - Hirashiki A
FAU - Takeshita, Kyosuke
AU  - Takeshita K
FAU - Murohara, Toyoaki
AU  - Murohara T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20161223
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
SB  - IM
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/*physiopathology
MH  - Follow-Up Studies
MH  - *Heart Rate
MH  - Humans
MH  - Middle Aged
MH  - *Myocardial Contraction
MH  - Retrospective Studies
MH  - *Ventricular Function, Left
EDAT- 2016/12/28 06:00
MHDA- 2017/03/11 06:00
CRDT- 2016/12/28 06:00
PHST- 2016/12/28 06:00 [pubmed]
PHST- 2017/03/11 06:00 [medline]
PHST- 2016/12/28 06:00 [entrez]
AID - 10.1253/circj.CJ-16-1007 [doi]
PST - ppublish
SO  - Circ J. 2017 Feb 24;81(3):368-375. doi: 10.1253/circj.CJ-16-1007. Epub 2016 Dec 
      23.