PMID- 28025511
OWN - NLM
STAT- MEDLINE
DCOM- 20170411
LR  - 20181113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 1
DP  - 2016 Dec 22
TI  - Immunological Roles of Elevated Plasma Levels of Matricellular Proteins in 
      Japanese Patients with Pulmonary Tuberculosis.
LID - 10.3390/ijms18010019 [doi]
LID - 19
AB  - Elevated matricellular proteins (MCPs), including osteopontin (OPN) and 
      galectin-9 (Gal-9), were observed in the plasma of patients with Manila-type 
      tuberculosis (TB) previously. Here, we quantified plasma OPN, Gal-9, and soluble 
      CD44 (sCD44) by enzyme-linked immunosorbent assay (ELISA), and another 29 
      cytokines by Luminex assay in 36 patients with pulmonary TB, six subjects with 
      latent tuberculosis (LTBI), and 19 healthy controls (HCs) from Japan for a better 
      understanding of the roles of MCPs in TB. All TB subjects showed positive results 
      of enzyme-linked immunospot assays (ELISPOTs). Spoligotyping showed that 20 out 
      of 36 Mycobacterium tuberculosis (MTB) strains belong to the Beijing type. The 
      levels of OPN, Gal-9, and sCD44 were higher in TB (positivity of 61.1%, 66.7%, 
      and 63.9%, respectively) than in the HCs. Positive correlations between OPN and 
      Gal-9, between OPN and sCD44, and negative correlation between OPN and 
      ESAT-6-ELISPOT response, between chest X-ray severity score of cavitary TB and 
      ESAT-6-ELISPOT response were observed. Instead of OPN, Gal-9, and sCD44, 
      cytokines G-CSF, GM-CSF, IFN-alpha, IFN-gamma, IL-12p70, and IL-1RA levels were higher in 
      Beijing MTB-infected patients. These findings suggest immunoregulatory, rather 
      than inflammatory, effect of MCPs and can advance the understanding of the roles 
      of MCPs in the context of TB pathology.
FAU - Shiratori, Beata
AU  - Shiratori B
AD  - Division of Disaster-Related Infectious Diseases, International Research 
      Institute of Disaster Science, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, 
      Sendai, Miyagi 980-8575, Japan. beatabucekova@gmail.com.
FAU - Zhao, Jingge
AU  - Zhao J
AD  - Division of Disaster-Related Infectious Diseases, International Research 
      Institute of Disaster Science, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, 
      Sendai, Miyagi 980-8575, Japan. zhaojingge1987@gmail.com.
FAU - Okumura, Masao
AU  - Okumura M
AD  - Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis 
      Association, 3-1-24 Matsuyama, Kiyose, Tokyo 204-8533, Japan. 
      okumuram@fukujuji.org.
FAU - Chagan-Yasutan, Haorile
AU  - Chagan-Yasutan H
AD  - Division of Disaster-Related Infectious Diseases, International Research 
      Institute of Disaster Science, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, 
      Sendai, Miyagi 980-8575, Japan. haorile@gmail.com.
FAU - Yanai, Hideki
AU  - Yanai H
AD  - Department of Clinical Laboratory, Fukujuji Hospital, Japan Anti-Tuberculosis 
      Association, 3-1-2 4 Matsuyama, Kiyose, Tokyo 204-8533, Japan. 
      yanaih@fukujuji.org.
FAU - Mizuno, Kazue
AU  - Mizuno K
AD  - Department of Clinical Laboratory, Fukujuji Hospital, Japan Anti-Tuberculosis 
      Association, 3-1-2 4 Matsuyama, Kiyose, Tokyo 204-8533, Japan. 
      hiralin99@yahoo.co.jp.
FAU - Yoshiyama, Takashi
AU  - Yoshiyama T
AD  - Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis 
      Association, 3-1-24 Matsuyama, Kiyose, Tokyo 204-8533, Japan. 
      yoshiyamat@fukujuji.org.
FAU - Idei, Tadashi
AU  - Idei T
AD  - Department of Clinical Laboratory, Fukujuji Hospital, Japan Anti-Tuberculosis 
      Association, 3-1-2 4 Matsuyama, Kiyose, Tokyo 204-8533, Japan. 
      ideit@fukujuji.org.
FAU - Ashino, Yugo
AU  - Ashino Y
AD  - Division of Disaster-Related Infectious Diseases, International Research 
      Institute of Disaster Science, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, 
      Sendai, Miyagi 980-8575, Japan. ya82@yahoo.co.jp.
FAU - Nakajima, Chie
AU  - Nakajima C
AD  - Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido 
      University, North 20, West 10, Kita-ku, Sapporo, Hokkaido 001-0020, Japan. 
      cnakajim@czc.hokudai.ac.jp.
FAU - Suzuki, Yasuhiko
AU  - Suzuki Y
AD  - Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido 
      University, North 20, West 10, Kita-ku, Sapporo, Hokkaido 001-0020, Japan. 
      suzuki@czc.hokudai.ac.jp.
FAU - Hattori, Toshio
AU  - Hattori T
AD  - Department of Health Science and Social Welfare, Kibi International University, 8 
      Igamachi, Takahashi 716-8508, Japan. hattorit@kiui.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20161222
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Galectins)
RN  - 0 (Hyaluronan Receptors)
RN  - 106441-73-0 (Osteopontin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Galectins/*blood
MH  - Humans
MH  - Hyaluronan Receptors/*blood
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium tuberculosis/classification/genetics/isolation & purification
MH  - Osteopontin/*blood
MH  - Tuberculosis, Pulmonary/*blood/immunology/microbiology
PMC - PMC5297654
OTO - NOTNLM
OT  - Beijing genotype MTB
OT  - CD44
OT  - galectin-9
OT  - osteopontin
OT  - tuberculosis
COIS- The authors declare no conflicts of interest.
EDAT- 2016/12/28 06:00
MHDA- 2017/04/12 06:00
PMCR- 2017/01/01
CRDT- 2016/12/28 06:00
PHST- 2016/11/24 00:00 [received]
PHST- 2016/12/16 00:00 [revised]
PHST- 2016/12/16 00:00 [accepted]
PHST- 2016/12/28 06:00 [entrez]
PHST- 2016/12/28 06:00 [pubmed]
PHST- 2017/04/12 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - ijms18010019 [pii]
AID - ijms-18-00019 [pii]
AID - 10.3390/ijms18010019 [doi]
PST - epublish
SO  - Int J Mol Sci. 2016 Dec 22;18(1):19. doi: 10.3390/ijms18010019.