PMID- 28026029
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20201209
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Linking)
VI  - 81
IP  - 2
DP  - 2017 Feb
TI  - Anti-LGI1 encephalitis is associated with unique HLA subtypes.
PG  - 183-192
LID - 10.1002/ana.24860 [doi]
AB  - OBJECTIVE: Autoimmune encephalitis (AE), represented by anti-leucine-rich 
      glioma-inactivated 1 (anti-LGI1) and anti-N-methyl-D-aspartate receptor 
      (anti-NMDAR) encephalitis, has increasing clinical significance based on recent 
      discoveries of neuronal autoantibodies. However, its immunopathogenesis is not 
      fully understood. Here, we investigated whether AE is associated with the human 
      leukocyte antigen (HLA) subtypes. METHODS: We compared the HLA genotypes of 11 
      anti-LGI1 and 17 anti-NMDAR encephalitis patients to the control groups, which 
      consisted of 210 epilepsy patients and 485 healthy Koreans. RESULTS: Anti-LGI1 
      encephalitis was associated with the DRB1*07:01-DQB1*02:02 haplotype (10 
      patients; 91%) in HLA class II genes, as well as with B*44:03 (8 patients; 73%) 
      and C*07:06 (7 patients; 64%) in the HLA class I region. The prevalence of these 
      alleles in anti-LGI1 encephalitis was significantly higher than that in the 
      epilepsy controls or healthy controls. By contrast, anti-NMDAR encephalitis was 
      not associated with HLA genotypes. Additional analysis using HLA-peptide binding 
      prediction algorithms and computational docking underpinned the close 
      relationship. INTERPRETATION: This finding suggests that most anti-LGI1 
      encephalitis develops in a population with specific HLA subtypes, providing 
      insight into a novel disease mechanism. Ann Neurol 2017;81:183-192.
CI  - (c) 2016 American Neurological Association.
FAU - Kim, Tae-Joon
AU  - Kim TJ
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
FAU - Lee, Soon-Tae
AU  - Lee ST
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
FAU - Moon, Jangsup
AU  - Moon J
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
FAU - Sunwoo, Jun-Sang
AU  - Sunwoo JS
AD  - Department of Neurology, Soonchunhyang University Seoul Hospital, Seoul, South 
      Korea.
FAU - Byun, Jung-Ick
AU  - Byun JI
AD  - Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, South 
      Korea.
FAU - Lim, Jung-Ah
AU  - Lim JA
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
FAU - Shin, Yong-Won
AU  - Shin YW
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
FAU - Jun, Jin-Sun
AU  - Jun JS
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
FAU - Lee, Han Sang
AU  - Lee HS
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
FAU - Lee, Woo-Jin
AU  - Lee WJ
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
FAU - Yang, Ah Reaum
AU  - Yang AR
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
FAU - Choi, Yunhee
AU  - Choi Y
AD  - Medical Research Collaborating Center, Seoul National University Hospital, Seoul, 
      South Korea.
FAU - Park, Kyung-Il
AU  - Park KI
AD  - Department of Neurology, Seoul National University Hospital Healthcare System 
      Gangnam Center, Seoul, South Korea.
FAU - Jung, Keun-Hwa
AU  - Jung KH
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
FAU - Jung, Ki-Young
AU  - Jung KY
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
FAU - Kim, Manho
AU  - Kim M
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
AD  - Protein Metabolism Medical Research Center, Seoul National University College of 
      Medicine, Seoul, South Korea.
FAU - Lee, Sang Kun
AU  - Lee SK
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
FAU - Chu, Kon
AU  - Chu K
AD  - Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (LGI1 protein, human)
RN  - 0 (Proteins)
SB  - IM
CIN - Ann Neurol. 2017 Feb;81(2):181-182. PMID: 28026032
CIN - Epilepsy Curr. 2017 Sep-Oct;17 (5):273-274. PMID: 29225536
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/genetics/immunology
MH  - Autoantibodies
MH  - Encephalitis/*genetics/*immunology
MH  - Female
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - Male
MH  - Middle Aged
MH  - Proteins/*immunology
MH  - Young Adult
EDAT- 2016/12/28 06:00
MHDA- 2017/07/01 06:00
CRDT- 2016/12/28 06:00
PHST- 2016/06/08 00:00 [received]
PHST- 2016/11/21 00:00 [revised]
PHST- 2016/11/22 00:00 [accepted]
PHST- 2016/12/28 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2016/12/28 06:00 [entrez]
AID - 10.1002/ana.24860 [doi]
PST - ppublish
SO  - Ann Neurol. 2017 Feb;81(2):183-192. doi: 10.1002/ana.24860.