PMID- 28026046
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20201209
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Linking)
VI  - 81
IP  - 2
DP  - 2017 Feb
TI  - Anti-LGI1 encephalitis is strongly associated with HLA-DR7 and HLA-DRB4.
PG  - 193-198
LID - 10.1002/ana.24858 [doi]
AB  - Leucine-rich glioma-inactivated1 (LGI1) encephalitis is an antibody-associated 
      inflammation of the limbic area. An autoimmune etiology is suspected but not yet 
      proven. We performed human leukocyte antigen (HLA) analysis in 25 nontumor 
      anti-LGI1 patients and discovered a remarkably strong HLA association. HLA-DR7 
      was present in 88% compared to 19.6% in healthy controls (p = 4.1 x 10(-11) ). 
      HLA-DRB4 was present in all patients and in 46.5% controls (p = 1.19 x 10(-7) ). 
      These findings support the autoimmune hypothesis. An exploratory analysis was 
      performed in a small group of 4 tumor-LGI1 patients. The strong HLA association 
      seems not applicable in these patients. Therefore, the absence of HLA-DR7 or 
      HLA-DRB4 could raise tumor suspicion in anti-LGI1 patients. Ann Neurol 
      2017;81:193-198.
CI  - (c) 2016 American Neurological Association.
FAU - van Sonderen, Agnes
AU  - van Sonderen A
AD  - Department of Neurology, Erasmus University Medical Center, Rotterdam.
AD  - Department of Neurology, Haga Hospital, the Hague.
FAU - Roelen, Dave L
AU  - Roelen DL
AD  - Department of Immunogenetics and Transplantation Immunology, Leiden University 
      Medical Center, Leiden.
FAU - Stoop, Johannes A
AU  - Stoop JA
AD  - Department of Pathology, Erasmus University Medical Center, Rotterdam.
FAU - Verdijk, Robert M
AU  - Verdijk RM
AD  - Department of Pathology, Erasmus University Medical Center, Rotterdam.
FAU - Haasnoot, Geert W
AU  - Haasnoot GW
AD  - Department of Immunogenetics and Transplantation Immunology, Leiden University 
      Medical Center, Leiden.
FAU - Thijs, Roland D
AU  - Thijs RD
AD  - Foundation Epilepsy Institutes Netherlands, Heemstede.
AD  - Department of Neurology, Leiden University Medical Center, Leiden.
FAU - Wirtz, Paul W
AU  - Wirtz PW
AD  - Department of Neurology, Haga Hospital, the Hague.
FAU - Schreurs, Marco W J
AU  - Schreurs MW
AD  - Department of Immunology, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
FAU - Claas, Frans H J
AU  - Claas FH
AD  - Department of Immunogenetics and Transplantation Immunology, Leiden University 
      Medical Center, Leiden.
FAU - Sillevis Smitt, Peter A E
AU  - Sillevis Smitt PA
AD  - Department of Neurology, Erasmus University Medical Center, Rotterdam.
FAU - Titulaer, Maarten J
AU  - Titulaer MJ
AD  - Department of Neurology, Erasmus University Medical Center, Rotterdam.
LA  - eng
PT  - Journal Article
DEP - 20170127
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DR7 Antigen)
RN  - 0 (HLA-DRB4 Chains)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (LGI1 protein, human)
RN  - 0 (Proteins)
SB  - IM
CIN - Ann Neurol. 2017 Feb;81(2):181-182. PMID: 28026032
CIN - Epilepsy Curr. 2017 Sep-Oct;17 (5):273-274. PMID: 29225536
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoantibodies
MH  - Encephalitis/*genetics/*immunology
MH  - Female
MH  - HLA-DR7 Antigen/*genetics
MH  - HLA-DRB4 Chains/*genetics
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - Male
MH  - Middle Aged
MH  - Proteins/*immunology
EDAT- 2016/12/28 06:00
MHDA- 2017/07/01 06:00
CRDT- 2016/12/28 06:00
PHST- 2016/08/02 00:00 [received]
PHST- 2016/11/21 00:00 [revised]
PHST- 2016/11/22 00:00 [accepted]
PHST- 2016/12/28 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2016/12/28 06:00 [entrez]
AID - 10.1002/ana.24858 [doi]
PST - ppublish
SO  - Ann Neurol. 2017 Feb;81(2):193-198. doi: 10.1002/ana.24858. Epub 2017 Jan 27.