PMID- 28027409
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20220318
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 106
IP  - 3
DP  - 2017 Mar
TI  - Atopic dermatitis is associated with a fivefold increased risk of 
      polysensitisation in children.
PG  - 485-488
LID - 10.1111/apa.13729 [doi]
AB  - AIM: It has been hypothesised that in atopic dermatitis, the dysfunctional skin 
      barrier facilitates the transcutaneous presentation of allergens to the immune 
      system. This study examined whether atopic dermatitis increased the likelihood of 
      polysensitisation, namely sensitisation to five or more allergens. METHODS: We 
      examined the electronic hospital charts of 1743 children aged 0-17 years who had 
      visited primary or secondary care physicians with allergic symptoms, whose blood 
      was examined for the presence of specific immunoglobulin E (IgE) to the 10 most 
      common inhaled and food allergens and whose files contained documentation of the 
      presence of atopic dermatitis and other skin disorders. Sensitisation was defined 
      as a specific IgE level of >/=0.35 kU/L. RESULTS: Polysensitisation was more common 
      in children with atopic dermatitis (268/1197, 22.4%) than those without (30/546, 
      5.5%, p < 0.001). This remained significant after adjustment for gender and age 
      in a multiple logistic regression model (odds ratio: 5.63, 95% confidence 
      interval 3.77-8.40). Other skin disorders did not show an increased risk of 
      polysensitisation (5/97, 5.2%). CONCLUSION: Polysensitisation was considerably 
      more common in children with atopic dermatitis than those without. This supports 
      the hypothesis that sensitisation occurs through a defective skin barrier and 
      appears to be specific for atopic dermatitis.
CI  - (c)2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
FAU - Broeks, Suzanne A
AU  - Broeks SA
AD  - Department of Internal Medicine, ZGT Hospital, Almelo, The Netherlands.
FAU - Brand, Paul L P
AU  - Brand PL
AD  - Princess Amalia Children's Centre, Isala Hospital, Zwolle, The Netherlands.
AD  - UMCG Postgraduate School of Medicine, University Medical Centre and University of 
      Groningen, Groningen, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20170119
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Dermatitis, Atopic/complications/epidemiology/*immunology
MH  - Female
MH  - Food Hypersensitivity/immunology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Netherlands/epidemiology
MH  - Respiratory Hypersensitivity/immunology
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Polysensitisation
OT  - Skin barrier
OT  - Specific immunoglobulin E
OT  - Transcutaneous sensitisation
EDAT- 2016/12/28 06:00
MHDA- 2018/07/28 06:00
CRDT- 2016/12/28 06:00
PHST- 2016/08/29 00:00 [received]
PHST- 2016/12/12 00:00 [revised]
PHST- 2016/12/21 00:00 [accepted]
PHST- 2016/12/28 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2016/12/28 06:00 [entrez]
AID - 10.1111/apa.13729 [doi]
PST - ppublish
SO  - Acta Paediatr. 2017 Mar;106(3):485-488. doi: 10.1111/apa.13729. Epub 2017 Jan 19.