PMID- 28027922
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20181203
IS  - 1872-9754 (Electronic)
IS  - 0197-0186 (Linking)
VI  - 103
DP  - 2017 Feb
TI  - The protective effect of resveratrol in the transmission of neuropathic pain 
      mediated by the P2X(7) receptor in the dorsal root ganglia.
PG  - 24-35
LID - S0197-0186(16)30353-9 [pii]
LID - 10.1016/j.neuint.2016.12.006 [doi]
AB  - The P2X(7) receptor mediates afferent nerve activation and is related to chronic 
      neuropathic pain. Resveratrol (RES) has also been reported to exhibit 
      anti-inflammatory effects. In this study, we investigated the neuroprotective 
      effect of RES on the transmission of neuropathic pain mediated by the P2X(7) 
      receptor. The P2X(7) mRNA and protein expression levels in L4-L5 dorsal root 
      ganglia (DRG)s of the chronic constriction injury (CCI) group were significantly 
      higher than those observed in the Ctrl + NS, Sham + RES and Sham groups. RES 
      increased the threshold of thermal and mechanical hypersensitivity in rats with 
      chronic neuropathic pain. The P2X(7) mRNA and protein expression levels in the 
      CCI + RES group were decreased compared with those in the CCI group. Our results 
      showed that RES inhibited the upregulated co-expression of P2X(7) and glial 
      fibrillary acidic protein (GFAP, a marker of satellite glial cells) in satellite 
      glial cells of DRG in the CCI group. The results demonstrated that the expression 
      of GFAP was increased in the CCI group and that RES inhibited the upregulated 
      expression of GFAP in the rats in the CCI group. In addition, the phosphorylation 
      levels of p38 and extracellular regulated protein kinases (ERK)1/2 in the CCI 
      group were markedly higher than those observed in the Ctrl + NS, Sham + RES and 
      Sham groups, whereas the phosphorylation levels of p38 and ERK1/2 in CCI + RES 
      group were markedly lower than those observed in the CCI group. RES inhibited 
      BzATP-activated currents in DRG non-neurons in the CCI rats. Our data provide 
      evidence that RES may suppress the transmission of neuropathic pain mediated by 
      the P2X(7) receptor in the satellite glial cells of dorsal root ganglia.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Xie, Jinyan
AU  - Xie J
AD  - Department of Physiology, Basic Medical College of Nanchang University, Nanchang, 
      PR China; Key Laboratory of Molecular Medicine of JiangXi, The Second Affiliated 
      Hospital of Nanchang University, Nanchang, PR China.
FAU - Liu, Shuangmei
AU  - Liu S
AD  - Department of Physiology, Basic Medical College of Nanchang University, Nanchang, 
      PR China.
FAU - Wu, Bing
AU  - Wu B
AD  - Department of Physiology, Basic Medical College of Nanchang University, Nanchang, 
      PR China.
FAU - Li, Guilin
AU  - Li G
AD  - Department of Physiology, Basic Medical College of Nanchang University, Nanchang, 
      PR China.
FAU - Rao, Shenqiang
AU  - Rao S
AD  - Department of Physiology, Basic Medical College of Nanchang University, Nanchang, 
      PR China.
FAU - Zou, Lifang
AU  - Zou L
AD  - Department of Physiology, Basic Medical College of Nanchang University, Nanchang, 
      PR China.
FAU - Yi, Zhihua
AU  - Yi Z
AD  - Department of Physiology, Basic Medical College of Nanchang University, Nanchang, 
      PR China.
FAU - Zhang, Chunping
AU  - Zhang C
AD  - Department of Physiology, Basic Medical College of Nanchang University, Nanchang, 
      PR China.
FAU - Jia, Tianyu
AU  - Jia T
AD  - Department of Physiology, Basic Medical College of Nanchang University, Nanchang, 
      PR China.
FAU - Zhao, Shanhong
AU  - Zhao S
AD  - Department of Physiology, Basic Medical College of Nanchang University, Nanchang, 
      PR China.
FAU - Schmalzing, Gunther
AU  - Schmalzing G
AD  - Molecular Pharmacology of RWTH Aachen University, Aachen, D-52072, Germany.
FAU - Hausmann, Ralf
AU  - Hausmann R
AD  - Molecular Pharmacology of RWTH Aachen University, Aachen, D-52072, Germany.
FAU - Nie, Hong
AU  - Nie H
AD  - Pharmacology of Traditional Chinese Medicine of Jinan University, Guangzhou, PR 
      China.
FAU - Li, Guodong
AU  - Li G
AD  - Department of Physiology, Basic Medical College of Nanchang University, Nanchang, 
      PR China; Department of Clinical Translational Research, Singapore General 
      Hospital, Singapore.
FAU - Liang, Shangdong
AU  - Liang S
AD  - Department of Physiology, Basic Medical College of Nanchang University, Nanchang, 
      PR China. Electronic address: liangsd@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20161224
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Receptors, Purinergic P2X7)
RN  - 0 (Stilbenes)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Ganglia, Spinal/*drug effects
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hyperalgesia/drug therapy
MH  - Male
MH  - Neuralgia/*drug therapy/metabolism
MH  - Pain Measurement/methods
MH  - Rats, Sprague-Dawley
MH  - Receptors, Purinergic P2X7/*metabolism
MH  - Resveratrol
MH  - Stilbenes/*pharmacology
OTO - NOTNLM
OT  - Dorsal root ganglia
OT  - Neuropathic pain
OT  - P2X(7) receptor
OT  - Resveratrol
OT  - Satellite glial cell
EDAT- 2016/12/29 06:00
MHDA- 2018/01/03 06:00
CRDT- 2016/12/29 06:00
PHST- 2016/10/01 00:00 [received]
PHST- 2016/11/24 00:00 [revised]
PHST- 2016/12/15 00:00 [accepted]
PHST- 2016/12/29 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
PHST- 2016/12/29 06:00 [entrez]
AID - S0197-0186(16)30353-9 [pii]
AID - 10.1016/j.neuint.2016.12.006 [doi]
PST - ppublish
SO  - Neurochem Int. 2017 Feb;103:24-35. doi: 10.1016/j.neuint.2016.12.006. Epub 2016 
      Dec 24.