PMID- 28027994
OWN - NLM
STAT- MEDLINE
DCOM- 20170808
LR  - 20221207
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 55
DP  - 2017 Feb
TI  - Variations in IL-1R1 Gene Influence Risk for Hepatitis B Virus Infection of 
      Children in a Han Chinese population.
PG  - 45-50
LID - S1201-9712(16)31665-4 [pii]
LID - 10.1016/j.ijid.2016.12.021 [doi]
AB  - BACKGROUND/AIMS: Host genetic factors play an important role in the pathogenesis 
      of hepatitis B virus (HBV) infection. However, the role of Interleukin1Receptor, 
      Type I (IL-1R1) gene in HBV infection and breakthrough infection in children 
      remains unclear. The aim of this study was to investigate the association between 
      SNPs in IL-1 family and HBV infection and breakthrough infection in children. 
      PATIENTS AND METHODS: A total of 627 Chinese children (274 HBV infected children 
      and 353 controls) ages 6 months to 12 years were recruited from October 2013 to 
      May 2015.Six SNPs were genotyped in IL-1R1, Interleukin-1beta (IL-1B) and 
      Interleukin-18 (IL-18) genes. RESULTS: A statistically significant association 
      was found between genotype AA in rs3917267 (IL-1R1) and HBV infection in children 
      (OR, 1.740; 95%CI, 1.091-2.774; p=0.020), which was also found at allele A (OR, 
      1.316;95%CI, 1.050-1.648; p=0.017). Furthermore, rs3917267 was also significantly 
      associated with breakthrough infection of HBV in children born of hepatitis B 
      surface antigen (HBsAg) positive mothers (OR,3.675; 95%CI, 1.160-11.646; 
      P=0.027). CONCLUSION: Our study confirmed that genetic variant in 
      IL-1R1(rs3917267) has significant association with HBV infection and HBV 
      breakthrough infection in children, which provides new clues for the study of 
      pathogenesis of chronic HBV infection in children.
CI  - Copyright (c) 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Fan, Jie
AU  - Fan J
AD  - Department of Epidemiology, School of Public Health and Management, Research 
      Center for Medicine and Social Development, Innovation Center for Social Risk 
      Governance in Health, Chongqing Medical University, Chongqing 400016, China.
FAU - Cai, Yiling
AU  - Cai Y
AD  - Department of Obstetrics and Gynecology, the Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400010, China.
FAU - Huang, Xin
AU  - Huang X
AD  - Department of Epidemiology, School of Public Health and Management, Research 
      Center for Medicine and Social Development, Innovation Center for Social Risk 
      Governance in Health, Chongqing Medical University, Chongqing 400016, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Foreign Language College of Chongqing Medical University, Chongqing 400016, 
      China.
FAU - Mu, Lihong
AU  - Mu L
AD  - Department of Epidemiology, School of Public Health and Management, Research 
      Center for Medicine and Social Development, Innovation Center for Social Risk 
      Governance in Health, Chongqing Medical University, Chongqing 400016, China. 
      Electronic address: 1097123703@qq.com.
FAU - Zhou, Li
AU  - Zhou L
AD  - Department of Epidemiology, School of Public Health and Management, Research 
      Center for Medicine and Social Development, Innovation Center for Social Risk 
      Governance in Health, Chongqing Medical University, Chongqing 400016, China. 
      Electronic address: zhouli_tj@163.com.
LA  - eng
PT  - Journal Article
DEP - 20161224
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Surface Antigens)
RN  - 0 (Receptors, Interleukin-1 Type I)
SB  - IM
MH  - Alleles
MH  - Asian People/*genetics
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Disease Outbreaks
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Hepatitis B/*epidemiology/*genetics/immunology
MH  - Hepatitis B Antibodies/blood
MH  - Hepatitis B Surface Antigens/blood
MH  - Hepatitis B virus/immunology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Population Surveillance
MH  - Receptors, Interleukin-1 Type I/*genetics
OTO - NOTNLM
OT  - HBV
OT  - breakthrough infection
OT  - children
OT  - single nucleotide polymorphism
EDAT- 2016/12/29 06:00
MHDA- 2017/08/09 06:00
CRDT- 2016/12/29 06:00
PHST- 2016/09/23 00:00 [received]
PHST- 2016/12/07 00:00 [revised]
PHST- 2016/12/15 00:00 [accepted]
PHST- 2016/12/29 06:00 [pubmed]
PHST- 2017/08/09 06:00 [medline]
PHST- 2016/12/29 06:00 [entrez]
AID - S1201-9712(16)31665-4 [pii]
AID - 10.1016/j.ijid.2016.12.021 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2017 Feb;55:45-50. doi: 10.1016/j.ijid.2016.12.021. Epub 2016 
      Dec 24.