PMID- 28028159
OWN - NLM
STAT- MEDLINE
DCOM- 20170620
LR  - 20221207
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Print)
IS  - 1462-0324 (Linking)
VI  - 56
IP  - 1
DP  - 2017 Jan
TI  - Racial differences in health-related quality of life and functional ability in 
      patients with gout.
PG  - 103-112
LID - 10.1093/rheumatology/kew356 [doi]
AB  - OBJECTIVE: To compare the health-related quality of life (HRQOL) and the 
      functional ability by race in patients with gout. METHODS: In a 9-month 
      prospective cohort multicentre study, patients with gout self-reported race, 
      dichotomized as Caucasian or African American (others excluded). We calculated 
      HRQOL/function scores adjusted for age, study site and college education for 
      Short Form-36 (SF-36; generic HRQOL), Gout Impact Scale (GIS; disease-specific 
      HRQOL) and HAQ-disability index (HAQ-DI; functional ability). Longitudinally 
      adjusted scores were computed using multivariable mixed-effect regression models 
      with a random patient effect and fixed sequential visit effect (3-monthly 
      visits). RESULTS: Compared with Caucasians (n = 107), African Americans (n = 60) 
      with gout were younger (61.1 vs 67.3 years) and had higher median baseline serum 
      urate (9.0 vs 7.9 mg/dl) (P < 0.01). African Americans with gout had worse HRQOL 
      scores on three SF-36 domains, the mental component summary (MCS) and two of the 
      five GIS scales than Caucasians [mean (se); P ⩽ 0.02 for all]: SF-36 mental 
      health, 39.7 (1.1) vs 45.2 (0.9); SF-36 role emotional, 42.1 (4.2) vs 51.4 (4.2); 
      SF-36 social functioning, 36.0 (1.1) vs 40.0 (0.9) (P = 0.04); SF-36 MCS, 43.2 
      (3.1) vs 50.0 (3.2); GIS unmet treatment need, 37.6 (1.6) vs 31.5 (1.4); and GIS 
      concern during attacks, 53.3 (3.7) vs 47.4 (3.7). Differences between the 
      respective HAQ-DI total scores were not statistically significant; 0.98 (0.1) vs 
      0.80 (1.0) (P = 0.11). Racial differences in SF-36 mental health, role emotional 
      and MCS scales exceeded, and for HAQ-DI approached, the minimal clinically 
      important difference thresholds. CONCLUSIONS: African Americans with gout have 
      significantly worse HRQOL compared with Caucasians. Further research is necessary 
      in the form of studies targeted at African Americans on how best to improve these 
      outcomes.
CI  - Published by Oxford University Press on behalf of the British Society for 
      Rheumatology 2016. This work is written by US Government employees and is in the 
      public domain in the US.
FAU - Singh, Jasvinder A
AU  - Singh JA
AD  - Medicine Service, Birmingham VA Medical Center Jasvinder.md@gmail.com.
AD  - Department of Medicine, School of Medicine.
AD  - Division of Epidemiology, School of Public Health, University of Alabama at 
      Birmingham, Birmingham, AL.
AD  - Department of Orthopedic Surgery, Mayo Clinic College of Medicine, Rochester, MN.
FAU - Bharat, Aseem
AU  - Bharat A
AD  - Department of Medicine, School of Medicine.
AD  - Division of Epidemiology, School of Public Health, University of Alabama at 
      Birmingham, Birmingham, AL.
FAU - Khanna, Dinesh
AU  - Khanna D
AD  - Department of Medicine, University of Michigan, Ann Arbor, MI.
FAU - Aquino-Beaton, Cleopatra
AU  - Aquino-Beaton C
AD  - Department of Biostatistics, VA Greater Los Angeles Healthcare System.
FAU - Persselin, Jay E
AU  - Persselin JE
AD  - Department of Biostatistics, VA Greater Los Angeles Healthcare System.
FAU - Duffy, Erin
AU  - Duffy E
AD  - Department of Medicine, University of California, Los Angeles, CA.
FAU - Elashoff, David
AU  - Elashoff D
AD  - Department of Medicine, University of California, Los Angeles, CA.
FAU - Khanna, Puja P
AU  - Khanna PP
AD  - Department of Medicine, University of Michigan, Ann Arbor, MI.
AD  - Department of Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
LA  - eng
GR  - K24 AR063120/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
DEP - 20161025
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
SB  - IM
MH  - *Activities of Daily Living
MH  - *Black or African American
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Gout/*physiopathology/psychology
MH  - Health Services Needs and Demand
MH  - *Health Status
MH  - *Health Status Disparities
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Mental Health
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Regression Analysis
MH  - Severity of Illness Index
MH  - Social Participation
MH  - United States
MH  - United States Department of Veterans Affairs
MH  - *White People
PMC - PMC5188996
OTO - NOTNLM
OT  - HRQOL
OT  - disparity
OT  - function
OT  - gout
OT  - health-related quality of life
OT  - race
OT  - racial
EDAT- 2016/12/29 06:00
MHDA- 2017/06/21 06:00
PMCR- 2018/01/01
CRDT- 2016/12/29 06:00
PHST- 2015/12/17 00:00 [received]
PHST- 2016/08/24 00:00 [revised]
PHST- 2016/12/29 06:00 [entrez]
PHST- 2016/12/29 06:00 [pubmed]
PHST- 2017/06/21 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - kew356 [pii]
AID - 10.1093/rheumatology/kew356 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2017 Jan;56(1):103-112. doi: 10.1093/rheumatology/kew356. 
      Epub 2016 Oct 25.