PMID- 28028589
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20180309
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 409
IP  - 8
DP  - 2017 Mar
TI  - Ultrasound-air-assisted demulsified liquid-liquid microextraction by 
      solidification of a floating organic droplet for determination of three 
      antifungal drugs in water and biological samples.
PG  - 2119-2126
LID - 10.1007/s00216-016-0158-9 [doi]
AB  - A novel ultrasound-air-assisted demulsified liquid-liquid microextraction by 
      solidification of a floating organic droplet (UAAD-LLM-SFO) followed by HPLC-UV 
      detection was developed for the analysis of three antifungal drugs in water and 
      biological samples. In this method, 1-dodecanol was used as the extraction 
      solvent. The emulsion was rapidly formed by pulling in and pushing out the 
      mixture of sample solution and extraction solvent for 5 times repeatedly using a 
      10-mL glass syringe while sonication was performed. Therefore, an organic 
      dispersive solvent required in common microextraction methods was not used in the 
      proposed method. After dispersing, an aliquot of acetonitrile was introduced as a 
      demulsifier solvent into the sample solution to separate two phases. Therefore, 
      some additional steps, such as the centrifugation, ultrasonication, or agitation 
      of the sample solution, are not needed. Parameters influencing the extraction 
      recovery were investigated. The proposed method showed a good linearity for the 
      three antifungal drugs studied with the correlation coefficients (R 
      (2) > 0.9995). The limits of detection (LODs) and the limits of the 
      quantification (LOQs) were between 0.01-0.03 mug L(-1) and 0.03-0.08 mug L(-1), 
      respectively. The preconcentration factors (PFs) were in the range of 107-116, 
      respectively. The precisions, as the relative standard deviations (RSDs) (n = 5), 
      for inter-day and intra-day analysis were in the range of 2.1-4.5% and 6.5-8.5%, 
      respectively. This method was successfully applied to determine the three 
      antifungal drugs in tap water and biological samples. The recoveries of 
      antifungal drugs in these samples were 92.4-98.5%. Graphical abstract 
      Ultrasound-air-assisted demulsified liquid-liquid microextraction by 
      solidification of a floating organic droplet for the analysis of three antifungal 
      drugs prior HPLC-UV.
FAU - Ezoddin, Maryam
AU  - Ezoddin M
AD  - Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, 
      Iran. maryams77@gmail.com.
FAU - Shojaie, Mehran
AU  - Shojaie M
AD  - Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, 
      Iran.
FAU - Abdi, Khosrou
AU  - Abdi K
AD  - Department of Medicinal Chemistry and Radiopharmacy, Faculty of Pharmacy, Tehran 
      University of Medical Sciences, Tehran, 1417614411, Iran.
AD  - Drug Design and Development Research Center, Tehran University of Medical 
      Sciences, Tehran, 1417614411, Iran.
FAU - Karimi, Mohammad Ali
AU  - Karimi MA
AD  - Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, 
      Iran.
LA  - eng
PT  - Journal Article
DEP - 20161227
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Antifungal Agents)
RN  - 0 (Emulsions)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Antifungal Agents/*analysis
MH  - Emulsions
MH  - Limit of Detection
MH  - Liquid Phase Microextraction/*methods
MH  - Reproducibility of Results
MH  - *Ultrasonics
MH  - Water/*chemistry
OTO - NOTNLM
OT  - Antifungal drugs
OT  - Demulsified liquid-liquid microextraction
OT  - Solidification of a floating organic droplet
OT  - Ultrasound air assisted
EDAT- 2016/12/29 06:00
MHDA- 2018/03/10 06:00
CRDT- 2016/12/29 06:00
PHST- 2016/08/14 00:00 [received]
PHST- 2016/12/15 00:00 [accepted]
PHST- 2016/10/31 00:00 [revised]
PHST- 2016/12/29 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
PHST- 2016/12/29 06:00 [entrez]
AID - 10.1007/s00216-016-0158-9 [pii]
AID - 10.1007/s00216-016-0158-9 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2017 Mar;409(8):2119-2126. doi: 10.1007/s00216-016-0158-9. 
      Epub 2016 Dec 27.