PMID- 28028928
OWN - NLM
STAT- MEDLINE
DCOM- 20180417
LR  - 20180417
IS  - 1522-7243 (Electronic)
IS  - 1522-7235 (Linking)
VI  - 32
IP  - 5
DP  - 2017 Aug
TI  - New phthalimide-appended Schiff bases: Studies of DNA binding, molecular docking 
      and antioxidant activities.
PG  - 829-838
LID - 10.1002/bio.3259 [doi]
AB  - Herein, we investigated new phthalimide-based Schiff base molecules as promising 
      DNA-binding and free radical scavenging agents. Physicochemical properties of 
      these molecules were demonstrated on the basis of elemental analysis, 
      ultraviolet-visible (UV-Vis), infra-red (IR), (1) H and (13) C nuclear magnetic 
      resonance (NMR) spectroscopy. All spectral data are agreed well with the proposed 
      Schiff base framework. The DNA-binding potential of synthesized compounds were 
      investigated by means of UV-visible, fluorescence, iodide quenching, circular 
      dichroism, viscosity and thermal denaturation studies. The intrinsic binding 
      constants (K(b) ) were calculated from absorption studies were found to be 
      1.1 x 10(4) and 1.0 x 10(4)  M(-1) for compounds 2a and 2b suggesting that 
      compound 2a binding abilities with DNA were stronger than the compound 2b. Our 
      studies showed that the presented compounds interact with DNA through groove 
      binding. Molecular docking studies were carried out to predict the binding 
      between Ct-DNA and test compounds. Interestingly, in silico predictions were 
      corroborated with in vitro DNA-binding conclusions. Furthermore, the title 
      compounds displayed remarkable antioxidant activity compared with reference 
      standard.
CI  - Copyright (c) 2016 John Wiley & Sons, Ltd.
FAU - Nayab, Pattan Sirajuddin
AU  - Nayab PS
AD  - Department of Chemistry, Jamia Millia Islamia, New Delhi, India.
FAU - Akrema
AU  - Akrema
AD  - Department of Chemistry, Jamia Millia Islamia, New Delhi, India.
FAU - Ansari, Istikhar A
AU  - Ansari IA
AD  - Department of Chemistry, Aligarh Muslim University, Aligarh, India.
FAU - Shahid, Mohammad
AU  - Shahid M
AD  - Department of Chemistry, Aligarh Muslim University, Aligarh, India.
FAU - Rahisuddin
AU  - Rahisuddin
AD  - Department of Chemistry, Jamia Millia Islamia, New Delhi, India.
LA  - eng
PT  - Journal Article
DEP - 20161228
PL  - England
TA  - Luminescence
JT  - Luminescence : the journal of biological and chemical luminescence
JID - 100889025
RN  - 0 (Antioxidants)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Iodides)
RN  - 0 (Phthalimides)
RN  - 0 (Picrates)
RN  - 0 (Schiff Bases)
RN  - 9007-49-2 (DNA)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
SB  - IM
MH  - Antioxidants/*chemistry
MH  - Biphenyl Compounds/chemistry
MH  - Circular Dichroism
MH  - DNA/chemistry/*metabolism
MH  - Hydrogen Peroxide/chemistry
MH  - Inhibitory Concentration 50
MH  - Iodides/chemistry
MH  - Magnetic Resonance Spectroscopy
MH  - Molecular Docking Simulation
MH  - Osmolar Concentration
MH  - Phthalimides/*chemistry/metabolism
MH  - Picrates/chemistry
MH  - Schiff Bases/*chemistry/metabolism
MH  - Spectrophotometry, Infrared
MH  - Spectrophotometry, Ultraviolet
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Viscosity
OTO - NOTNLM
OT  - DNA binding
OT  - Schiff base
OT  - antioxidant
OT  - molecular docking
EDAT- 2016/12/29 06:00
MHDA- 2018/04/18 06:00
CRDT- 2016/12/29 06:00
PHST- 2016/07/29 00:00 [received]
PHST- 2016/10/22 00:00 [revised]
PHST- 2016/10/26 00:00 [accepted]
PHST- 2016/12/29 06:00 [pubmed]
PHST- 2018/04/18 06:00 [medline]
PHST- 2016/12/29 06:00 [entrez]
AID - 10.1002/bio.3259 [doi]
PST - ppublish
SO  - Luminescence. 2017 Aug;32(5):829-838. doi: 10.1002/bio.3259. Epub 2016 Dec 28.