PMID- 28029000
OWN - NLM
STAT- MEDLINE
DCOM- 20170207
LR  - 20220408
IS  - 2234-3814 (Electronic)
IS  - 2234-3806 (Print)
IS  - 2234-3806 (Linking)
VI  - 37
IP  - 2
DP  - 2017 Mar
TI  - Comparison Between Soluble ST2 and High-Sensitivity Troponin I in Predicting 
      Short-Term Mortality for Patients Presenting to the Emergency Department With 
      Chest Pain.
PG  - 137-146
LID - 10.3343/alm.2017.37.2.137 [doi]
AB  - BACKGROUND: High-sensitivity cardiac troponin I (hs-cTnI) and the soluble isoform 
      of suppression of tumorigenicity 2 (sST2) are useful prognostic biomarkers in 
      acute coronary syndrome (ACS). The aim of this study was to test the short term 
      prognostic value of sST2 compared with hs-cTnI in patients with chest pain. 
      METHODS: Assays for hs-cTnI and sST2 were performed in 157 patients admitted to 
      the Emergency Department (ED) for chest pain at arrival. In-hospital and 30-day 
      follow-up mortalities were assessed. RESULTS: The incidence of ACS was 37%; 33 
      patients were diagnosed with ST elevation myocardial infarction (STEMI), and 25 
      were diagnosed with non-ST elevation myocardial infarction (NSTEMI). Compared 
      with the no acute coronary syndrome (NO ACS) group, the median level of hs-cTnI 
      was higher in ACS patients: 7.22 (5.24-14) pg/mL vs 68 (15.33-163.50) pg/mL 
      (P<0.0001). In all patients, the sST2 level at arrival showed higher independent 
      predictive power than hs-cTnI (odds ratio [OR] 20.13, P<0.0001 and OR 2.61, 
      P<0.0008, respectively). sST2 at ED arrival showed a greater prognostic value for 
      cardiovascular events in STEMI (area under the curve [AUC] 0.80, P<0.001) than 
      NSTEMI patients (AUC 0.72, P<0.05). Overall, 51% of the STEMI patients with an 
      sST2 value>35 ng/mL at ED arrival died during the 30-day follow-up. CONCLUSIONS: 
      sST2 has a greater prognostic value for 30-day cardiac mortality after discharge 
      in patients presenting to the ED for chest pain compared with hs-cTnI. In STEMI 
      patients, an sST2 value >35 ng/mL at ED arrival showed the highest predictive 
      power for short-term mortality.
FAU - Marino, Rossella
AU  - Marino R
AD  - Department of Medical-Surgery Sciences and Translational Medicine, University 
      Sapienza Rome, Sant' Andrea Hospital, Rome, Italy.
FAU - Magrini, Laura
AU  - Magrini L
AD  - Department of Medical-Surgery Sciences and Translational Medicine, University 
      Sapienza Rome, Sant' Andrea Hospital, Rome, Italy.
FAU - Orsini, Francesca
AU  - Orsini F
AD  - Department of Medical-Surgery Sciences and Translational Medicine, University 
      Sapienza Rome, Sant' Andrea Hospital, Rome, Italy.
FAU - Russo, Veronica
AU  - Russo V
AD  - Department of Medical-Surgery Sciences and Translational Medicine, University 
      Sapienza Rome, Sant' Andrea Hospital, Rome, Italy.
FAU - Cardelli, Patrizia
AU  - Cardelli P
AD  - Clinical and Molecular Medicine Department, Sant' Andrea Hospital, School of 
      Medicine and Psychology, "Sapienza" University, Rome, Italy.
FAU - Salerno, Gerardo
AU  - Salerno G
AD  - Clinical and Molecular Medicine Department, Sant' Andrea Hospital, School of 
      Medicine and Psychology, "Sapienza" University, Rome, Italy.
FAU - Hur, Mina
AU  - Hur M
AD  - Department of Laboratory Medicine, School of Medicine, Konkuk University, Seoul, 
      Korea.
FAU - Di Somma, Salvatore
AU  - Di Somma S
AD  - Department of Medical-Surgery Sciences and Translational Medicine, University 
      Sapienza Rome, Sant' Andrea Hospital, Rome, Italy. salvatore.disomma@uniroma1.it.
CN  - GREAT NETWORK
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Ann Lab Med
JT  - Annals of laboratory medicine
JID - 101571172
RN  - 0 (Biomarkers)
RN  - 0 (IL1RL1 protein, human)
RN  - 0 (Interleukin-1 Receptor-Like 1 Protein)
RN  - 0 (Troponin I)
SB  - IM
MH  - Acute Coronary Syndrome/diagnosis/*mortality
MH  - Aged
MH  - Area Under Curve
MH  - Biomarkers/analysis
MH  - Chest Pain
MH  - Emergency Service, Hospital
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Interleukin-1 Receptor-Like 1 Protein/*analysis
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Prognosis
MH  - ROC Curve
MH  - Troponin I/*analysis
PMC - PMC5203991
OTO - NOTNLM
OT  - 30 day mortality
OT  - Acute coronary syndrome
OT  - Chest pain
OT  - Emergency Department
OT  - Prognosis
OT  - hs-cTnI
OT  - sST2
COIS- Authors' Disclosures of Potential Conflicts of Interest: No potential conflicts 
      of interest relevant to this article were reported.
EDAT- 2016/12/29 06:00
MHDA- 2017/02/09 06:00
PMCR- 2017/03/01
CRDT- 2016/12/29 06:00
PHST- 2016/07/19 00:00 [received]
PHST- 2016/09/21 00:00 [revised]
PHST- 2016/12/05 00:00 [accepted]
PHST- 2017/03/01 00:00 [pmc-release]
PHST- 2016/12/29 06:00 [entrez]
PHST- 2016/12/29 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
AID - 37.137 [pii]
AID - 10.3343/alm.2017.37.2.137 [doi]
PST - ppublish
SO  - Ann Lab Med. 2017 Mar;37(2):137-146. doi: 10.3343/alm.2017.37.2.137.