PMID- 28030536
OWN - NLM
STAT- MEDLINE
DCOM- 20170424
LR  - 20190606
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 22
DP  - 2016 Dec 28
TI  - Effect of Refractive Correction Error on Retinal Nerve Fiber Layer Thickness: A 
      Spectralis Optical Coherence Tomography Study.
PG  - 5181-5189
AB  - BACKGROUND Identifying and assessing retinal nerve fiber layer defects are 
      important for diagnosing and managing glaucoma. We aimed to investigate the 
      effect of refractive correction error on retinal nerve fiber layer (RNFL) 
      thickness measured with Spectralis spectral-domain optical coherence tomography 
      (SD-OCT). MATERIAL AND METHODS We included 68 participants: 32 healthy (normal) 
      and 36 glaucoma patients. RNFL thickness was measured using Spectralis SD-OCT 
      circular scan. Measurements were made with a refractive correction of the 
      spherical equivalent (SE), the SE+2.00D and the SE-2.00D. RESULTS Average RNFL 
      thickness was significantly higher in the normal group (105.88+/-10.47 mum) than in 
      the glaucoma group (67.67+/-17.27 mum, P<0.001). In the normal group, +2.00D of 
      refractive correction error significantly affected measurements of average 
      (P<0.001) and inferior quadrant (P=0.037) RNFL thickness. In the glaucoma group, 
      +2.00D of refractive correction error significantly increased average (P<0.001) 
      and individual quadrant (superior: P=0.016; temporal: P=0.004; inferior: P=0.008; 
      nasal: P=0.003) RNFL measurements compared with those made with the proper 
      refractive correction. However, -2.00D of refractive correction error did not 
      significantly affect RNFL thickness measurements in either group. CONCLUSIONS 
      Positive defocus error significantly affects RNFL thickness measurements made by 
      the Spectralis SD-OCT. Negative defocus error did not affect RNFL measurement 
      examined. Careful correction of refractive error is necessary to obtain accurate 
      baseline and follow-up RNFL thickness measurements in healthy and glaucomatous 
      eyes.
FAU - Ma, Xiaoli
AU  - Ma X
AD  - Department of Ophthalmology, The First Hospital of China Medical University, 
      Shenyang, Liaoning, China (mainland).
FAU - Chen, Yutong
AU  - Chen Y
AD  - Department of Ophthalmology, The First Hospital of China Medical University, 
      Shenyang, Liaoning, China (mainland).
FAU - Liu, Xianjie
AU  - Liu X
AD  - Department of Ophthalmology, The First Hospital of China Medical University, 
      Shenyang, Liaoning, China (mainland).
FAU - Ning, Hong
AU  - Ning H
AD  - Department of Ophthalmology, The First Hospital of China Medical University, 
      Shenyang, Liaoning, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20161228
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
SB  - IM
MH  - Demography
MH  - Female
MH  - Glaucoma/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Refractive Errors/*diagnosis
MH  - Retina/*pathology
MH  - Tomography, Optical Coherence/*methods
PMC - PMC5215193
EDAT- 2016/12/29 06:00
MHDA- 2017/04/25 06:00
PMCR- 2016/12/28
CRDT- 2016/12/29 06:00
PHST- 2016/12/29 06:00 [entrez]
PHST- 2016/12/29 06:00 [pubmed]
PHST- 2017/04/25 06:00 [medline]
PHST- 2016/12/28 00:00 [pmc-release]
AID - 898564 [pii]
AID - 10.12659/msm.898564 [doi]
PST - epublish
SO  - Med Sci Monit. 2016 Dec 28;22:5181-5189. doi: 10.12659/msm.898564.