PMID- 28031094
OWN - NLM
STAT- MEDLINE
DCOM- 20181010
LR  - 20191113
IS  - 1001-9294 (Print)
IS  - 1001-9294 (Linking)
VI  - 31
IP  - 2
DP  - 2016 Jun 20
TI  - Determinants of Detection of Stones and Calcifications in the Hepatobiliary 
      System on Virtual Nonenhanced Dual-energy CT.
PG  - 76-82
AB  - Objective To retrospectively determine the features of stones and calcifications 
      in hepatobiliary system on virtual nonenhanced (VNE) dual-energy computed 
      tomography (CT), and to evaluate the possibility of VNE images in diagnosis for 
      those lesions.Methods A total of 128 gall stones and calcifications of the liver 
      found in 110 patients were examined with triple phase abdominal CT scan from July 
      2007 to December 2011, in which true nonenhanced (TNE) phase and arterial phase 
      were performed with single-energy CT (120 kVp) and portal venous phase was 
      performed with dual-energy CT (100 kVp and 140 kVp). VNE images were generated 
      from the portal venous phase dual-energy CT data sets by using commercially VNC 
      software. The mean CT values for the stone, liver, bile and paraspinal muscle, 
      mean lesion density and size in area dimension, contrast-to-noise ratio (CNR) of 
      lesion to the liver or bile, and image noise were assessed and compared between 
      VNE and TNE images. The effective dose and size-specific dose estimate (SSDE) 
      were also calculated.Results The mean CT values of the lesions measured on VNE 
      images declined significantly compared with those measured on TNE images 
      (164.51+/-102.13 vs. 290.72+/-197.80 HU, P<0.001), so did the lesion-to-liver CNR 
      (10.80+/-11.82 vs.18.81+/-17.06, P<0.001) and the lesion-to-bile CNR (17.24+/-14.41 vs. 
      21.32+/-17.31, P<0.001). There was no significant difference in size of lesions 
      area between VNE and TNE images (0.69+/-0.88 vs. 0.72+/-0.85 cm(2), P=0.062). 
      Compared to the 128 lesions found in TNE images, VNE images showed the same 
      density in 30 (23.4%) lesions, lighter density in 88 (68.8%) lesions, while 
      failed to show 10 (7.8%) lesions, and showed the same size in 61 (47.7%) lesions 
      and smaller size in 57 (44.5%) lesions. The CT cutoff values of lesion and size 
      were 229.21 HU and 0.15 cm(2), respectively. The total effective dose for triple 
      phase scan protocol with TNE images was 19.51+/-7.03 mSv, and the SSDE was 
      39.84+/-11.10 mGy. The effective dose for dual phase scan protocol with VNE images 
      instead of TNE images was 13.29+/-4.89 mSv, and the SSDE was 27.83+/-9.99 mGy. 
      Compared with TNE images, the effective dose and SSDE of VNE images were down by 
      32.05%+/-3.69 % and 30.63%+/-2.34 %, respectively.Conclusions Although the CT values 
      and CNR of the lesions decreased in VNE images, the lesions of which attenuation 
      greater than 229.21 HU and size larger than 0.15 cm(2) could be detected with 
      good reliability and obvious dose reduction. There was good consistency in the 
      size of stones and calcifications in hepatobiliary system between VNE images and 
      TNE images, which ensured the possibility of the clinical application of VNE 
      images.
FAU - Zhang, Da-Ming
AU  - Zhang DM
FAU - Wang, Xuan
AU  - Wang X
FAU - Xue, Hua-Dan
AU  - Xue HD
FAU - Jin, Zheng-Yu
AU  - Jin ZY
FAU - Sun, Hao
AU  - Sun H
FAU - Chen, Yu
AU  - Chen Y
FAU - He, Yong-Lan
AU  - He YL
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med Sci J
JT  - Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
JID - 9112559
RN  - 0 (Contrast Media)
SB  - IM
MH  - Biliary Tract Diseases
MH  - Calcinosis
MH  - Cholelithiasis
MH  - Contrast Media
MH  - Humans
MH  - Portal Vein
MH  - Radiation Dosage
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Radiography, Dual-Energy Scanned Projection
MH  - Reproducibility of Results
MH  - *Tomography, X-Ray Computed
EDAT- 2016/12/30 06:00
MHDA- 2018/10/12 06:00
CRDT- 2016/12/30 06:00
PHST- 2016/12/30 06:00 [entrez]
PHST- 2016/12/30 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
AID - 10723 [pii]
AID - 10.1016/s1001-9294(16)30029-3 [doi]
PST - ppublish
SO  - Chin Med Sci J. 2016 Jun 20;31(2):76-82. doi: 10.1016/s1001-9294(16)30029-3.