PMID- 28031781
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 7
IP  - 20
DP  - 2016 Dec 15
TI  - Intermittent energy restriction in type 2 diabetes: A short discussion of 
      medication management.
PG  - 627-630
LID - 10.4239/wjd.v7.i20.627 [doi]
AB  - AIM: To discuss type 2 diabetes mellitus (T2DM) medication changes required 
      during the popular 5:2 intermittent energy restriction (IER) diet. METHODS: A 
      search was conducted in MEDLINE, EMBASE, AMED, CINAHL and Cochrane library for 
      original research articles investigating the use of very low calorie diets (VLCD) 
      in people with T2DM. The search terms used included "VLCD" or "very low energy 
      diet" or "very low energy restriction" or "IER" or "intermittent fasting" or 
      "calorie restriction" or "diabetes mellitus type 2" and "type 2 diabetes". 
      Reference lists of selected articles were also screened for relevant 
      publications. Only research articles written in English, which also included an 
      explanation of medication changes were included. A recent pilot trial using the 
      5:2 IER method, conducted by our research group, will also be summarized. 
      RESULTS: A total of 8 studies were found that investigated the use of VLCD in 
      T2DM and discussed medication management. Overall these studies indicate that the 
      use of a VLCD for people with T2DM usually require the cessation of medication to 
      prevent hypoglycemia. Therefore, the 5:2 IER method will also require medication 
      changes, but as seen in our pilot trial, may not require total cessation of 
      medication, rather a cessation on the 2 IER days only. CONCLUSION: Guidelines 
      outlined here can be used in the initial stages of a 2-d IER diet, but extensive 
      blood glucose monitoring is still required to make the necessary individual 
      reductions to medications in response to weight loss.
FAU - Carter, Sharayah
AU  - Carter S
AD  - Sharayah Carter, Peter M Clifton, Jennifer B Keogh, School of Pharmacy and 
      Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia.
FAU - Clifton, Peter M
AU  - Clifton PM
AD  - Sharayah Carter, Peter M Clifton, Jennifer B Keogh, School of Pharmacy and 
      Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia.
FAU - Keogh, Jennifer B
AU  - Keogh JB
AD  - Sharayah Carter, Peter M Clifton, Jennifer B Keogh, School of Pharmacy and 
      Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC5155237
OTO - NOTNLM
OT  - Caloric restriction
OT  - Diabetes complication
OT  - Diabetes mellitus/therapy
OT  - Fasting
OT  - Intermittent energy restriction
OT  - Medication management
OT  - Obesity
OT  - Type 2 diabetes mellitus
OT  - Very low calorie diet
EDAT- 2016/12/30 06:00
MHDA- 2016/12/30 06:01
PMCR- 2016/12/15
CRDT- 2016/12/30 06:00
PHST- 2016/07/01 00:00 [received]
PHST- 2016/09/16 00:00 [revised]
PHST- 2016/10/17 00:00 [accepted]
PHST- 2016/12/30 06:00 [entrez]
PHST- 2016/12/30 06:00 [pubmed]
PHST- 2016/12/30 06:01 [medline]
PHST- 2016/12/15 00:00 [pmc-release]
AID - 10.4239/wjd.v7.i20.627 [doi]
PST - ppublish
SO  - World J Diabetes. 2016 Dec 15;7(20):627-630. doi: 10.4239/wjd.v7.i20.627.