PMID- 28031835
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210109
IS  - 2051-3380 (Print)
IS  - 2051-3380 (Electronic)
IS  - 2051-3380 (Linking)
VI  - 4
IP  - 6
DP  - 2016 Nov
TI  - Pulmonary lymphoepithelioma-like carcinoma with echinoderm microtubule-associated 
      protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene.
PG  - e00200
LID - 10.1002/rcr2.200 [doi]
LID - e00200
AB  - A pulmonary lymphoepithelioma-like carcinoma (PLELC) is similar to a 
      lymphoepithelioma, a subtype of nasopharyngeal carcinoma and commonly associated 
      with Epstein-Barr virus infection which is a rare tumour and classified in the 
      group of "other and unclassified carcinoma" in the latest 2015 World Health 
      Organization (WHO) classification. Some reports of lymphoepithelioma-like 
      carcinoma (LELC) have noted an epidermal growth factor receptor (EGFR) mutation, 
      whereas none have noted a mutation of the echinoderm microtubule-associated 
      protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene. This is the 
      first reported case of PLELC with ALK rearrangement. A 76-year-old woman 
      underwent a right lower lobectomy and complicated partial resection of the upper 
      lobe with lymph node dissection under complete thoracoscopic approach. A 
      histopathological diagnosis of PLELC was made and the stage was classified as 
      T1aN1(#12l) M0, pl0, G2, Ly1, V1. The results of both ALK immunohistochemistry 
      and EML4-ALK fusion gene on fluorescence in situ hybridization (FISH) 
      examinations were positive; however, EGFR mutational analysis results showed 
      wild-type mutation.
FAU - Ose, Naoko
AU  - Ose N
AD  - Department of General Thoracic Surgery National Hospital Organization Toneyama 
      Hospital Osaka Japan.
FAU - Kawai, Teruka
AU  - Kawai T
AD  - Department of General Thoracic Surgery National Hospital Organization Toneyama 
      Hospital Osaka Japan.
FAU - Ishida, Daisuke
AU  - Ishida D
AD  - Department of General Thoracic Surgery National Hospital Organization Toneyama 
      Hospital Osaka Japan.
FAU - Kobori, Yuko
AU  - Kobori Y
AD  - Department of General Thoracic Surgery National Hospital Organization Toneyama 
      Hospital Osaka Japan.
FAU - Takeuchi, Yukiyasu
AU  - Takeuchi Y
AD  - Department of General Thoracic Surgery National Hospital Organization Toneyama 
      Hospital Osaka Japan.
FAU - Senba, Hidetoshi
AU  - Senba H
AD  - Department of Pathology National Hospital Organization Toneyama Hospital Osaka 
      Japan.
LA  - eng
PT  - Case Reports
DEP - 20161027
PL  - United States
TA  - Respirol Case Rep
JT  - Respirology case reports
JID - 101631052
PMC - PMC5167302
OTO - NOTNLM
OT  - ALK
OT  - EML4-ALK
OT  - lung
OT  - lymphoepithelioma-like carcinoma
OT  - pulmonary
EDAT- 2016/12/30 06:00
MHDA- 2016/12/30 06:01
PMCR- 2016/10/27
CRDT- 2016/12/30 06:00
PHST- 2016/08/19 00:00 [received]
PHST- 2016/09/27 00:00 [revised]
PHST- 2016/10/09 00:00 [accepted]
PHST- 2016/12/30 06:00 [entrez]
PHST- 2016/12/30 06:00 [pubmed]
PHST- 2016/12/30 06:01 [medline]
PHST- 2016/10/27 00:00 [pmc-release]
AID - RCR2200 [pii]
AID - 10.1002/rcr2.200 [doi]
PST - epublish
SO  - Respirol Case Rep. 2016 Oct 27;4(6):e00200. doi: 10.1002/rcr2.200. eCollection 
      2016 Nov.