PMID- 28033400
OWN - NLM
STAT- MEDLINE
DCOM- 20170710
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 12
DP  - 2016
TI  - Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell 
      Differentiation and Induce Less Severe Airway Inflammation in Murine Models.
PG  - e0168919
LID - 10.1371/journal.pone.0168919 [doi]
LID - e0168919
AB  - Dendritic cells (DCs) are critical for instructing immune responses toward 
      inflammatory or anti-inflammatory status. Heme oxygenase-1 (HO-1) is known for 
      its cytoprotective effect against oxidative stress and inflammation, suggesting 
      its immune regulatory role in allergic lung inflammation. HO-1 has been 
      implicated in affecting DC maturation; however, its role in DC-mediated T-cell 
      differentiation is unclear. In this study, we demonstrated that HO-1-expressing 
      bone marrow-derived dendritic cells (BM-DCs) displayed tolerogenic phenotypes, 
      including their resistance to lipopolysaccharide (LPS)-induced maturation, high 
      level expression of IL-10, and low T-cell stimulatory activity. In addition, 
      HO-1-expressing DCs were able to induce antigen-specific Foxp3+ regulatory T 
      cells (Treg) differentiation in vitro and in vivo. Also, HO-1-expressing DCs 
      modulated the severity of lung inflammatory responses in two murine models of 
      airway inflammation. This study provided evidence supporting the role of 
      HO-1-expressing DCs in tolerance induction and as a potential therapeutic target 
      for allergic asthma as well as other inflammatory diseases.
FAU - Wong, Tzu-Hsuan
AU  - Wong TH
AD  - Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
FAU - Chen, Hung-An
AU  - Chen HA
AD  - Department of Allergy-Immunology-Rheumatology, Chi-Mei Medical Center, Tainan, 
      Taiwan.
FAU - Gau, Rung-Jiun
AU  - Gau RJ
AD  - Biomedical Technology and Device Research Laboratories, Industrial Technology 
      Research Institute, Tainan, Taiwan.
FAU - Yen, Jeng-Hsien
AU  - Yen JH
AD  - Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan.
FAU - Suen, Jau-Ling
AU  - Suen JL
AD  - Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
AD  - Research Center for Environmental Medicine, Kaohsiung Medical University, 
      Kaohsiung, Taiwan.
AD  - Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20161229
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Metalloporphyrins)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/cytology
MH  - *Cell Differentiation/drug effects
MH  - Dendritic Cells/cytology/drug effects/*metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Forkhead Transcription Factors/*metabolism
MH  - *Gene Expression Regulation, Enzymologic/drug effects
MH  - Heme Oxygenase-1/*metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Metalloporphyrins/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Phenotype
MH  - Pneumonia/enzymology/*immunology/metabolism
MH  - T-Lymphocytes, Regulatory/*cytology/drug effects/immunology/metabolism
PMC - PMC5199094
COIS- The authors have declared that no competing interests exist.
EDAT- 2016/12/30 06:00
MHDA- 2017/07/14 06:00
PMCR- 2016/12/29
CRDT- 2016/12/30 06:00
PHST- 2016/05/25 00:00 [received]
PHST- 2016/12/08 00:00 [accepted]
PHST- 2016/12/30 06:00 [entrez]
PHST- 2016/12/30 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2016/12/29 00:00 [pmc-release]
AID - PONE-D-16-21014 [pii]
AID - 10.1371/journal.pone.0168919 [doi]
PST - epublish
SO  - PLoS One. 2016 Dec 29;11(12):e0168919. doi: 10.1371/journal.pone.0168919. 
      eCollection 2016.