PMID- 28036153
OWN - NLM
STAT- MEDLINE
DCOM- 20180629
LR  - 20220310
IS  - 1600-0714 (Electronic)
IS  - 0904-2512 (Linking)
VI  - 46
IP  - 9
DP  - 2017 Oct
TI  - Semiquantifiable angiogenesis parameters in association with the malignant 
      transformation of oral leukoplakia.
PG  - 710-716
LID - 10.1111/jop.12544 [doi]
AB  - BACKGROUND: Aim of the study was to assess the role of angiogenesis in the 
      process of malignant transformation of clinical diagnosed oral leucoplakia (OL). 
      MATERIALS AND METHODS: A total of 131 histological preparations [oral 
      leukoplakia/hyperkeratosis without dysplasia (OL; n = 49), oral 
      leukoplakia/hyperkeratosis with mild dysplasia (OL-SIN1; n = 33), with moderate 
      dysplasia (OL-SIN2; n = 13) and leukoplakia-derived oral squamous cell carcinoma 
      (OL-OSCC; n = 36)] were evaluated for microvessel density (MVD), vessel diameter 
      as well as for vascular endothelial growth factor (VEGF-A) expression. Data were 
      compared within the groups. RESULTS: For MVD, there were significant differences 
      between OL and OL-SIN 2/OL-OSCC (P < 0.05) and between OL-SIN 1 and OL-OSCC (P < 
      0.05). For OL-OSCC, vessel diameters were significantly increased compared with 
      OL (P < 0.05). Expression of VEGF-A increased significantly gradually from OL-SIN 
      1 to OSCC (each P < 0.05). This was especially evident for lesions of the tongue 
      when compared to the others. CONCLUSION: Angiogenesis increases during the 
      transition from OL through dysplasia to OL-OSCC. In particular, OL-OSCCs of the 
      tongue, VEGF-A expression may be used for estimation of malignant progression of 
      OL.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Thiem, Daniel G E
AU  - Thiem DGE
AD  - Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University 
      Medical Centre Rostock, Rostock, Germany.
FAU - Schneider, Schamiem
AU  - Schneider S
AD  - Private Dental Practice, Mainz, Germany.
FAU - Venkatraman, Narayan T
AU  - Venkatraman NT
AD  - Private Dental Practice, Bangalore, India.
FAU - Kumar, Vinay V
AU  - Kumar VV
AD  - Head and Neck Institute, Mazumdar Shaw Cancer Center, Narayana Health, 
      Bommasandra, Bangalore, India.
FAU - Brieger, Jurgen
AU  - Brieger J
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Molecular Tumor Biology 
      Laboratory, University Medical Centre Mainz, Mainz, Germany.
FAU - Frerich, Bernhard
AU  - Frerich B
AD  - Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University 
      Medical Centre Rostock, Rostock, Germany.
FAU - Kammerer, Peer W
AU  - Kammerer PW
AD  - Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University 
      Medical Centre Rostock, Rostock, Germany.
LA  - eng
PT  - Journal Article
DEP - 20170207
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/blood supply/*etiology/*pathology
MH  - Cell Transformation, Neoplastic
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Leukoplakia, Oral/*pathology
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/blood supply/*etiology/*pathology
MH  - *Neovascularization, Pathologic
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - mean microvessel density
OT  - oral cancer
OT  - precancerous lesions
OT  - tumour progression
OT  - vascular endothelial growth factor
EDAT- 2016/12/31 06:00
MHDA- 2018/06/30 06:00
CRDT- 2016/12/31 06:00
PHST- 2016/12/26 00:00 [accepted]
PHST- 2016/12/31 06:00 [pubmed]
PHST- 2018/06/30 06:00 [medline]
PHST- 2016/12/31 06:00 [entrez]
AID - 10.1111/jop.12544 [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2017 Oct;46(9):710-716. doi: 10.1111/jop.12544. Epub 2017 Feb 
      7.