PMID- 28039778
OWN - NLM
STAT- MEDLINE
DCOM- 20170411
LR  - 20170411
IS  - 1873-2682 (Electronic)
IS  - 1011-1344 (Linking)
VI  - 166
DP  - 2017 Jan
TI  - Spectroscopic studies on the interactions between novel bisnaphthalimide 
      derivatives and calf thymus DNA.
PG  - 333-340
LID - S1011-1344(16)30792-8 [pii]
LID - 10.1016/j.jphotobiol.2016.12.003 [doi]
AB  - The types of interactions between six novel bisnaphthalimide derivatives (AITHN, 
      BITHN, PITHN, PyITHN, DN6 and DNT6) and calf thymus DNA in a physiological buffer 
      (Tris-HCl buffer solutions, pH=7.4) were investigated using UV-vis 
      spectrophotometry, fluorescence spectroscopy, and a competition experiment, in 
      order to explore the relationships between the linkers of bisnaphthalimide 
      derivatives and their activity. The absorption spectra of the six 
      bisnaphthalimide derivatives with DNA showed a slight red shift and hypochromic 
      effect. DNA quenched the compounds (AITHN, PITHN, PyITHN and DN6) by a static 
      quenching process. Using acridine orange (AO) dye as a fluorescence probe, 
      fluorescence quenching of the emission peak was observed in the AO-DNA system 
      with the addition of PITHN, but the maximum emission intensity was elevated for 
      AITHN and DN6 while the other three compounds showed no obvious change. The 
      calculated binding constants of AITHN, PITHN, PyITHN and DN6 with DNA were 
      2.09x10(5)Lmol(-1), 1.14x10(5)Lmol(-1), 0.95x10(5)Lmol(-1) and 2.39x10(5)Lmol(-1) 
      respectively, and the number of binding sites were 0.618, 0.323, 0.297 and 0.769. 
      Intercalative and electrostatic binding were the two major modes between the six 
      bisnaphthalimide derivatives and calf thymus DNA. The strength of the 
      intercalation was related to the type of linker. Moreover, DN6 and AITHN had the 
      greatest intercalative ability. The electrostatic binding ability of the six 
      compounds was independent of the type of linker present.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - He, Dongye
AU  - He D
AD  - School of Life Science and Technology, Dalian University of Technology, Dalian 
      116024, China; Ministry of Education Center for Food Safety of Animal Origin, 
      Dalian 116620, China.
FAU - Wang, Lili
AU  - Wang L
AD  - School of Life Science and Technology, Dalian University of Technology, Dalian 
      116024, China; Ministry of Education Center for Food Safety of Animal Origin, 
      Dalian 116620, China.
FAU - Wang, Liping
AU  - Wang L
AD  - School of Life Science and Technology, Dalian University of Technology, Dalian 
      116024, China; Ministry of Education Center for Food Safety of Animal Origin, 
      Dalian 116620, China.
FAU - Li, Xiaoyu
AU  - Li X
AD  - School of Life Science and Technology, Dalian University of Technology, Dalian 
      116024, China; Ministry of Education Center for Food Safety of Animal Origin, 
      Dalian 116620, China.
FAU - Xu, Yongping
AU  - Xu Y
AD  - School of Life Science and Technology, Dalian University of Technology, Dalian 
      116024, China; Ministry of Education Center for Food Safety of Animal Origin, 
      Dalian 116620, China. Electronic address: hechen2287@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20161209
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
RN  - 0 (Naphthalimides)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - DNA/*chemistry
MH  - Naphthalimides/*chemistry
MH  - Spectrometry, Fluorescence
MH  - Spectrophotometry, Ultraviolet
OTO - NOTNLM
OT  - Binding mode
OT  - Bisnaphthalimide
OT  - Calf thymus DNA
OT  - Spectroscopy
EDAT- 2017/01/01 06:00
MHDA- 2017/04/12 06:00
CRDT- 2017/01/01 06:00
PHST- 2016/09/14 00:00 [received]
PHST- 2016/11/10 00:00 [revised]
PHST- 2016/12/05 00:00 [accepted]
PHST- 2017/01/01 06:00 [pubmed]
PHST- 2017/04/12 06:00 [medline]
PHST- 2017/01/01 06:00 [entrez]
AID - S1011-1344(16)30792-8 [pii]
AID - 10.1016/j.jphotobiol.2016.12.003 [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 2017 Jan;166:333-340. doi: 
      10.1016/j.jphotobiol.2016.12.003. Epub 2016 Dec 9.