PMID- 28039843
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20180622
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 91
DP  - 2017 Mar
TI  - IL-3 and GM-CSF modulate functions of splenic macrophages in ENU induced 
      leukemia.
PG  - 89-95
LID - S1043-4666(16)30596-8 [pii]
LID - 10.1016/j.cyto.2016.12.009 [doi]
AB  - Leukemia is often accompanied by enhanced susceptibility to infection due to 
      compromised B cell and T cell functions. The alterations in macrophage functions 
      in leukemia remain less investigated. Herein, we examined macrophages for their 
      functions and responsiveness to IL-3 and GM-CSF in ENU-induced leukemia in BALB/c 
      mice. We observed that the macrophages from the leukemic mice had less phagocytic 
      activity, reduced chemotactic activity in response to monocyte chemoattractant 
      protein-1(MCP-1), and decreased expression of iNOS, GM-CSF, TLR2, TLR4, IFN-gamma and 
      TNF-alpha. These impaired macrophage functions in leukemic mice were significantly 
      corrected by IL-3 and GM-CSF treatment indicating the therapeutic benefit of 
      these two cytokines in leukemia.
CI  - Copyright A(c) 2016 Elsevier Ltd. All rights reserved.
FAU - Singha, Ashish Kumar
AU  - Singha AK
AD  - Immunology Microbiology Lab, Department of Human Physiology, Tripura University, 
      Suryamaninagar, Tripura 799022, India.
FAU - Bhattacharjee, Bhaskar
AU  - Bhattacharjee B
AD  - Immunology Microbiology Lab, Department of Human Physiology, Tripura University, 
      Suryamaninagar, Tripura 799022, India.
FAU - Saha, Bhaskar
AU  - Saha B
AD  - National Centre for Cell Science, Ganeshkhind, Pune 411 007, India.
FAU - Maiti, Debasish
AU  - Maiti D
AD  - Immunology Microbiology Lab, Department of Human Physiology, Tripura University, 
      Suryamaninagar, Tripura 799022, India. Electronic address: 
      debasish.maiti@tripurauniv.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161228
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Interleukin-3)
RN  - 0 (Neoplasm Proteins)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
RN  - P8M1T4190R (Ethylnitrosourea)
SB  - IM
MH  - Animals
MH  - Ethylnitrosourea/*toxicity
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/immunology/*pharmacology
MH  - Interleukin-3/immunology/*pharmacology
MH  - *Leukemia/chemically induced/drug therapy/immunology/pathology
MH  - Macrophages/*immunology/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neoplasm Proteins/*immunology
MH  - Spleen/*immunology/pathology
OTO - NOTNLM
OT  - Chemotaxis
OT  - Granulocyte macrophage-colony stimulating factor
OT  - IFN-gamma
OT  - Interleukin-3
OT  - Leukemia
OT  - Monocyte-derived macrophages
OT  - Nitric oxide synthase 2
OT  - Phagocytosis
OT  - TLRs
EDAT- 2017/01/01 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/01/01 06:00
PHST- 2016/05/13 00:00 [received]
PHST- 2016/12/06 00:00 [revised]
PHST- 2016/12/09 00:00 [accepted]
PHST- 2017/01/01 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
PHST- 2017/01/01 06:00 [entrez]
AID - S1043-4666(16)30596-8 [pii]
AID - 10.1016/j.cyto.2016.12.009 [doi]
PST - ppublish
SO  - Cytokine. 2017 Mar;91:89-95. doi: 10.1016/j.cyto.2016.12.009. Epub 2016 Dec 28.