PMID- 28042305
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2016
DP  - 2016
TI  - Vascular Contributions to Cognitive Impairment and Treatments with Traditional 
      Chinese Medicine.
PG  - 9627258
LID - 10.1155/2016/9627258 [doi]
LID - 9627258
AB  - The prevalence of cognitive impairment and dementia caused by cerebrovascular 
      disease is likely to increase with the global aging population. Vascular 
      contributions to cognitive impairment and dementia (VCID) is a wide spectrum term 
      used to include a diverse heterogeneous group of cognitive syndromes with 
      vascular factors regardless of the cause of pathogenesis. VCID ranges from mild 
      cognitive impairment to full-blown dementia with vascular dementia (VaD) as the 
      most severe stage. It is further complexed by the coexistence of other forms of 
      dementia such as Alzheimer's disease (AD). Recent researches in the functions of 
      the neurovascular unit (NVU) suggest that dysfunction of the NVU might be the 
      cause of primary vascular events in the brain that leads to further 
      neurodegeneration. In this review, we have briefly summarized various forms of 
      VCID. There is currently no standard therapy for VCID or dementia. Given the fact 
      that Traditional Chinese Medicine (TCM) has gained popularity worldwide, we also 
      reviewed recent scientific and clinical findings on various antidementia TCM for 
      the treatment of VCID, including Salvia miltiorrhiza, Huperzia serrata, 
      Ligusticum chuanxiong, Ginkgo biloba, Panax ginseng, and also TCM formula 
      Sailuotong capsule (SLT) and Fufangdanshen tablets (FFDS).
FAU - Zhou, Xinhua
AU  - Zhou X
AD  - State Key Laboratory of Quality Research in Chinese Medicine and Institute of 
      Chinese Medical Sciences, University of Macau, Macau.
FAU - Cui, Guozhen
AU  - Cui G
AD  - Department of Bioengineering, Zunyi Medical University, Zhuhai Campus, Guangdong, 
      Zhuhai, China.
FAU - Tseng, Hisa Hui Ling
AU  - Tseng HH
AD  - State Key Laboratory of Quality Research in Chinese Medicine and Institute of 
      Chinese Medical Sciences, University of Macau, Macau.
FAU - Lee, Simon Ming-Yuen
AU  - Lee SM
AD  - State Key Laboratory of Quality Research in Chinese Medicine and Institute of 
      Chinese Medical Sciences, University of Macau, Macau.
FAU - Leung, George Pak Heng
AU  - Leung GP
AD  - State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department 
      of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, 
      Hong Kong.
FAU - Chan, Shun Wan
AU  - Chan SW
AUID- ORCID: 0000-0001-8238-798X
AD  - State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department 
      of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, 
      Hong Kong; Department of Food and Health Sciences, Faculty of Science and 
      Technology, Technological and Higher Education Institute of Hong Kong, Hong Kong.
FAU - Kwan, Yiu Wa
AU  - Kwan YW
AUID- ORCID: 0000-0002-9024-1275
AD  - School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong.
FAU - Hoi, Maggie Pui Man
AU  - Hoi MP
AUID- ORCID: 0000-0003-2630-3707
AD  - State Key Laboratory of Quality Research in Chinese Medicine and Institute of 
      Chinese Medical Sciences, University of Macau, Macau.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161123
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5141557
COIS- The authors declare that they have no competing interests.
EDAT- 2017/01/04 06:00
MHDA- 2017/01/04 06:01
PMCR- 2016/11/23
CRDT- 2017/01/03 06:00
PHST- 2016/08/31 00:00 [received]
PHST- 2016/10/12 00:00 [revised]
PHST- 2016/10/18 00:00 [accepted]
PHST- 2017/01/03 06:00 [entrez]
PHST- 2017/01/04 06:00 [pubmed]
PHST- 2017/01/04 06:01 [medline]
PHST- 2016/11/23 00:00 [pmc-release]
AID - 10.1155/2016/9627258 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2016;2016:9627258. doi: 10.1155/2016/9627258. 
      Epub 2016 Nov 23.