PMID- 2804379
OWN - NLM
STAT- MEDLINE
DCOM- 19891215
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 74
IP  - 7
DP  - 1989 Nov 15
TI  - Bone marrow donor registries: the relation between registry size and probability 
      of finding complete and partial matches.
PG  - 2569-78
AB  - In a registry of volunteer bone marrow donors, the relation between registry size 
      and probability of finding an exact or partial match for a random recipient 
      cannot be theoretically derived because it depends on specifics of the human 
      leukocyte antigen (HLA) haplotype frequencies in the donor and recipient 
      populations. The relation must be explicitly calculated using empirically 
      determined HLA haplotype frequency data for all possible pairings between a donor 
      and a recipient population. This report describes a general solution to this 
      problem. The method shows that the relation of the probability of matching to 
      registry size is sigmoidal, with small increases in probability at the extremes 
      of registry size and a middle range of registry size within which the probability 
      of matching increases most sharply. This range determines the approximate size of 
      the most cost-effective registry. In addition, for any pairing of donor and 
      recipient populations, there is a maximum probability of identifying a match of a 
      given quality for a random recipient, which cannot be exceeded even if registry 
      size were infinite. This upper limit is a function of the frequency of blank (or 
      unknown) alleles in the donor and recipient populations; the higher that 
      frequency, the lower the maximum probability of achieving any given quality of 
      match. The determinants of the probability of achieving a given quality of match 
      with a given registry size are (1) the genetic heterogeneity within the recipient 
      and donor populations, which increases the registry size required to achieve a 
      given probability of matching, and (2) the degree of genetic homology between the 
      donor and recipient populations, which increases the maximum probability of 
      matching and also lowers registry size requirements. The method described here 
      can be used to estimate donor pool size requirements using any donor and 
      recipient populations for which HLA frequency data are available.
FAU - Sonnenberg, F A
AU  - Sonnenberg FA
AD  - Department of Medicine, New England Medical Center, Boston, MA 02111.
FAU - Eckman, M H
AU  - Eckman MH
FAU - Pauker, S G
AU  - Pauker SG
LA  - eng
GR  - LM3374/LM/NLM NIH HHS/United States
GR  - LM4022/LM/NLM NIH HHS/United States
GR  - LM7044/LM/NLM NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Blood. 1990 May 15;75(10):2093-4. PMID: 2337677
MH  - *Bone Marrow Transplantation
MH  - Gene Frequency
MH  - Genotype
MH  - HLA Antigens/analysis
MH  - Haplotypes
MH  - Histocompatibility
MH  - Humans
MH  - Probability
MH  - Terminology as Topic
MH  - *Tissue Donors
MH  - *Tissue and Organ Procurement
EDAT- 1989/11/15 00:00
MHDA- 1989/11/15 00:01
CRDT- 1989/11/15 00:00
PHST- 1989/11/15 00:00 [pubmed]
PHST- 1989/11/15 00:01 [medline]
PHST- 1989/11/15 00:00 [entrez]
AID - S0006-4971(20)82869-9 [pii]
PST - ppublish
SO  - Blood. 1989 Nov 15;74(7):2569-78.