PMID- 2804439
OWN - NLM
STAT- MEDLINE
DCOM- 19891129
LR  - 20071114
IS  - 0887-6134 (Print)
IS  - 0887-6134 (Linking)
VI  - 18
IP  - 8
DP  - 1989 Aug
TI  - Differentiation of isomeric 2'-, 3'- and 5'-deoxynucleosides by electron 
      ionization and chemical ionization-linked scanning mass spectrometry.
PG  - 533-42
AB  - A comparative mass spectral examination of the trimethylsilyl (TMS) derivatives 
      of 2'-, 3'- and 5'-deoxyadenosine, 2'-, 3'- and 5'-deoxyguanosine, 2'-, 3'- and 
      5'-deoxyxanothosine and 2'- and 5'-deoxy-2-fluoroadenosine is presented. A 
      general compilation of the major fragment ions found in the low-resolution 
      electron ionization (EI) spectra of the eleven deoxynucleosides is given. 
      Chemical ionization (CI)-collisional activation (CA) daughter ion spectra are 
      reported using the deoxyadenosines as model compounds. Ion structures and 
      fragmentation pathways are proposed for those ions characteristic of each of the 
      isomers. Significant differences in fragmentation exist between the isomeric 2'-, 
      3'- and 5'-purine deoxynucleosides. The formation and structures of ten ions 
      important in this differentiation are discussed. The CI-CA linked scan spectra 
      provide complementary structural information relative to the EI mass spectra.
FAU - Reimer, M L
AU  - Reimer ML
AD  - Department of Pharmaceutical Sciences, College of Pharmacy, University of 
      Arizona, Tucson 85721.
FAU - McClure, T D
AU  - McClure TD
FAU - Schram, K H
AU  - Schram KH
LA  - eng
GR  - CA 43068/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Biomed Environ Mass Spectrom
JT  - Biomedical & environmental mass spectrometry
JID - 8603224
RN  - 0 (Deoxyribonucleosides)
RN  - 0 (Trimethylsilyl Compounds)
SB  - IM
MH  - Deoxyribonucleosides/*analysis
MH  - Electrochemistry
MH  - Gas Chromatography-Mass Spectrometry
MH  - Isomerism
MH  - Molecular Weight
MH  - Trimethylsilyl Compounds/analysis
EDAT- 1989/08/01 00:00
MHDA- 1989/08/01 00:01
CRDT- 1989/08/01 00:00
PHST- 1989/08/01 00:00 [pubmed]
PHST- 1989/08/01 00:01 [medline]
PHST- 1989/08/01 00:00 [entrez]
AID - 10.1002/bms.1200180804 [doi]
PST - ppublish
SO  - Biomed Environ Mass Spectrom. 1989 Aug;18(8):533-42. doi: 10.1002/bms.1200180804.