PMID- 28049142
OWN - NLM
STAT- MEDLINE
DCOM- 20170901
LR  - 20171212
IS  - 1938-3673 (Electronic)
IS  - 0741-5400 (Linking)
VI  - 101
IP  - 1
DP  - 2017 Jan
TI  - Danger-associated molecular patterns in Alzheimer's disease.
PG  - 87-98
LID - 10.1189/jlb.3MR0416-204R [doi]
AB  - Pathogen-associated molecular patterns (PAMPs) and endogenous "danger" signals, 
      known as danger-associated molecular patterns (DAMPs), released from cells alert 
      the innate immune system and activate several signal transduction pathways 
      through interactions with the highly conserved pattern recognition receptors 
      (PRRs). Both PAMPs and DAMPs directly induce proinflammatory cascades and trigger 
      the formation of the inflammasome, mediating the release of cytokines. Here, we 
      highlight the role of DAMPs, including amyloid beta (Abeta), high-mobility group box 1 
      (HMGB1), the S100 family proteins, chromogranin A, and nucleic acids, in the 
      innate-immune activation during the course of Alzheimer disease (AD), the most 
      frequent neurodegenerative disorder.
CI  - (c) Society for Leukocyte Biology.
FAU - Venegas, Carmen
AU  - Venegas C
AD  - Department of Neurodegenerative Disease and Gerontopsychiatry, University of 
      Bonn, Bonn, Germany; and.
FAU - Heneka, Michael T
AU  - Heneka MT
AD  - Department of Neurodegenerative Disease and Gerontopsychiatry, University of 
      Bonn, Bonn, Germany; and michael.heneka@ukb.uni-bonn.de.
AD  - German Center for Neurodegenerative Disease, Bonn, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20161021
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Alarmins)
RN  - 0 (Receptors, Pattern Recognition)
SB  - IM
MH  - Alarmins/*metabolism
MH  - Alzheimer Disease/*metabolism
MH  - Animals
MH  - Humans
MH  - Inflammation/pathology
MH  - Models, Biological
MH  - Molecular Targeted Therapy
MH  - Receptors, Pattern Recognition/metabolism
OTO - NOTNLM
OT  - innate immune system
OT  - microglia
OT  - neurodegeneration
OT  - neuroinflammation
EDAT- 2017/01/04 06:00
MHDA- 2017/09/02 06:00
CRDT- 2017/01/04 06:00
PHST- 2016/04/27 00:00 [received]
PHST- 2016/09/02 00:00 [revised]
PHST- 2016/09/21 00:00 [accepted]
PHST- 2017/01/04 06:00 [entrez]
PHST- 2017/01/04 06:00 [pubmed]
PHST- 2017/09/02 06:00 [medline]
AID - jlb.3MR0416-204R [pii]
AID - 10.1189/jlb.3MR0416-204R [doi]
PST - ppublish
SO  - J Leukoc Biol. 2017 Jan;101(1):87-98. doi: 10.1189/jlb.3MR0416-204R. Epub 2016 
      Oct 21.