PMID- 28050569
OWN - NLM
STAT- MEDLINE
DCOM- 20170518
LR  - 20190723
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - The Expression Level of mRNA, Protein, and DNA Methylation Status of FOSL2 of 
      Uyghur in XinJiang in Type 2 Diabetes.
PG  - 5957404
LID - 10.1155/2016/5957404 [doi]
LID - 5957404
AB  - Objective. We investigated the expression levels of both FOSL2 mRNA and protein 
      as well as evaluating DNA methylation in the blood of type 2 diabetes mellitus 
      (T2DM) Uyghur patients from Xinjiang. This study also evaluated whether FOSL2 
      gene expression had demonstrated any associations with clinical and biochemical 
      indicators of T2DM. Methods. One hundred Uyghur subjects where divided into two 
      groups, T2DM and nonimpaired glucose tolerance (NGT) groups. DNA methylation of 
      FOSL2 was also analyzed by MassARRAY Spectrometry and methylation data of 
      individual units were generated by the EpiTyper v1.0.5 software. The expression 
      levels of FOS-like antigen 2 (FOSL2) and the protein expression levels were 
      analyzed. Results. Significant differences were observed in mRNA and protein 
      levels when compared with the NGT group, while methylation rates of eight CpG 
      units within the FOSL2 gene were higher in the T2DM group. Methylation of CpG 
      sites was found to inversely correlate with expression of other markers. 
      Conclusions. Results show that a correlation between mRNA, protein, and DNA 
      methylation of FOSL2 gene exists among T2DM patients from Uyghur. FOSL2 protein 
      and mRNA were downregulated and the DNA became hypermethylated, all of which may 
      be involved in T2DM pathogenesis in this population.
FAU - Li, Jun
AU  - Li J
AUID- ORCID: 0000-0002-1590-2336
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital, 
      Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China.
FAU - Li, Siyuan
AU  - Li S
AUID- ORCID: 0000-0003-0617-2279
AD  - Medical College, Shihezi University, Shihezi 832002, China.
FAU - Hu, Ying
AU  - Hu Y
AUID- ORCID: 0000-0003-2763-580X
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital, 
      Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China.
FAU - Cao, Guolei
AU  - Cao G
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital, 
      Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China; The First 
      Department of General Medicine, The Affiliated Tumor Hospital of Xinjiang Medical 
      University, Urumqi, Xinjiang 830000, China.
FAU - Wang, Siyao
AU  - Wang S
AUID- ORCID: 0000-0003-4362-1344
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital, 
      Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China; 
      Department of Endocrinology and Metabolism, The Fifth Affiliated Hospital, 
      Xinjiang Medicine University, Urumqi, Xinjiang 830000, China.
FAU - Rai, Partab
AU  - Rai P
AUID- ORCID: 0000-0002-6236-2408
AD  - Medical College, Shihezi University, Shihezi 832002, China.
FAU - Wang, Xiaoli
AU  - Wang X
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital, 
      Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China.
FAU - Sun, Kan
AU  - Sun K
AUID- ORCID: 0000-0002-5007-5081
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital, 
      Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China.
LA  - eng
PT  - Journal Article
DEP - 20161206
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (RNA, Messenger)
RN  - 0 (fos-related antigen 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - China
MH  - *DNA Methylation
MH  - Diabetes Mellitus, Type 2/genetics/*metabolism
MH  - Down-Regulation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-fos/genetics/*metabolism
MH  - RNA, Messenger/genetics/metabolism
PMC - PMC5168477
COIS- The authors declare that they have no competing interests.
EDAT- 2017/01/05 06:00
MHDA- 2017/05/19 06:00
PMCR- 2016/12/06
CRDT- 2017/01/05 06:00
PHST- 2016/09/05 00:00 [received]
PHST- 2016/10/25 00:00 [revised]
PHST- 2016/11/10 00:00 [accepted]
PHST- 2017/01/05 06:00 [entrez]
PHST- 2017/01/05 06:00 [pubmed]
PHST- 2017/05/19 06:00 [medline]
PHST- 2016/12/06 00:00 [pmc-release]
AID - 10.1155/2016/5957404 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:5957404. doi: 10.1155/2016/5957404. Epub 2016 Dec 6.