PMID- 28050692
OWN - NLM
STAT- MEDLINE
DCOM- 20180305
LR  - 20200330
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 27
IP  - 8
DP  - 2017 Aug
TI  - Effect of inversion time on the precision of myocardial late gadolinium 
      enhancement quantification evaluated with synthetic inversion recovery MR 
      imaging.
PG  - 3235-3243
LID - 10.1007/s00330-016-4665-z [doi]
AB  - OBJECTIVES: To evaluate the influence of inversion time (TI) on the precision of 
      myocardial late gadolinium enhancement (LGE) quantification using synthetic 
      inversion recovery (IR) imaging in patients with myocardial infarction (MI). 
      METHODS: Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI 
      with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and 
      T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were 
      calculated with a TI ranging from -100 to +150 ms at 5-ms intervals relative to 
      the optimal TI (TI(0)). LGE was quantified using a five standard deviation (5SD) 
      and full width at half-maximum (FWHM) thresholds. Measurements were compared 
      using one-way analysis of variance. RESULTS: The MagIR(sy) technique provided 
      precise assessment of LGE area at TIs >/= TI(0), while precision was decreased 
      below TI(0). The LGE area showed significant differences at </= -25 ms compared to 
      TI(0) using 5SD (P < 0.001) and at </= -65 ms using the FWHM approach (P < 0.001). 
      LGE measurements did not show significant difference over the analysed TI range 
      in the PSIR(sy) images using either of the quantification methods. CONCLUSIONS: 
      T1 map-based PSIR(sy) images provide precise quantification of MI independent of 
      TI at the investigated time point post-contrast. MagIR(sy)-based MI 
      quantification is precise at TI(0) and at longer TIs while showing decreased 
      precision at TI values below TI(0). KEY POINTS: * Synthetic IR imaging 
      retrospectively generates LGE images at any theoretical TI * Synthetic IR imaging 
      can simulate the effect of TI on LGE quantification * Fifteen minutes 
      post-contrast MagIR (sy) accurately quantifies infarcts from TI (0) to TI (0)   
      + 150 ms * Fifteen minutes post-contrast PSIR (sy) provides precise infarct size 
      independent of TI * Synthetic IR imaging has further advantages in reducing 
      operator dependence.
FAU - Varga-Szemes, Akos
AU  - Varga-Szemes A
AD  - Division of Cardiovascular Imaging, Department of Radiology and Radiological 
      Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay 
      Drive, Charleston, SC, 29425-2260, USA.
FAU - van der Geest, Rob J
AU  - van der Geest RJ
AD  - Department of Radiology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Schoepf, U Joseph
AU  - Schoepf UJ
AUID- ORCID: 0000-0002-6164-5641
AD  - Division of Cardiovascular Imaging, Department of Radiology and Radiological 
      Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay 
      Drive, Charleston, SC, 29425-2260, USA. schoepf@musc.edu.
FAU - Spottiswoode, Bruce S
AU  - Spottiswoode BS
AD  - Siemens Medical Solutions, Chicago, IL, USA.
FAU - De Cecco, Carlo N
AU  - De Cecco CN
AD  - Division of Cardiovascular Imaging, Department of Radiology and Radiological 
      Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay 
      Drive, Charleston, SC, 29425-2260, USA.
FAU - Muscogiuri, Giuseppe
AU  - Muscogiuri G
AD  - Division of Cardiovascular Imaging, Department of Radiology and Radiological 
      Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay 
      Drive, Charleston, SC, 29425-2260, USA.
AD  - Department of Imaging, Bambino Gesu Children's Hospital IRCCS, Rome, Italy.
FAU - Wichmann, Julian L
AU  - Wichmann JL
AD  - Division of Cardiovascular Imaging, Department of Radiology and Radiological 
      Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay 
      Drive, Charleston, SC, 29425-2260, USA.
AD  - Department of Diagnostic and Interventional Radiology, University Hospital 
      Frankfurt, Frankfurt, Germany.
FAU - Mangold, Stefanie
AU  - Mangold S
AD  - Division of Cardiovascular Imaging, Department of Radiology and Radiological 
      Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay 
      Drive, Charleston, SC, 29425-2260, USA.
AD  - Department of Diagnostic and Interventional Radiology, Eberhard-Karls University 
      Tuebingen, Tuebingen, Germany.
FAU - Fuller, Stephen R
AU  - Fuller SR
AD  - Division of Cardiovascular Imaging, Department of Radiology and Radiological 
      Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay 
      Drive, Charleston, SC, 29425-2260, USA.
FAU - Maurovich-Horvat, Pal
AU  - Maurovich-Horvat P
AD  - MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, 
      Semmelweis University, Budapest, Hungary.
FAU - Merkely, Bela
AU  - Merkely B
AD  - MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, 
      Semmelweis University, Budapest, Hungary.
FAU - Litwin, Sheldon E
AU  - Litwin SE
AD  - Division of Cardiology, Department of Medicine, Medical University of South 
      Carolina, Charleston, SC, USA.
FAU - Vliegenthart, Rozemarijn
AU  - Vliegenthart R
AD  - Division of Cardiovascular Imaging, Department of Radiology and Radiological 
      Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay 
      Drive, Charleston, SC, 29425-2260, USA.
AD  - Center for Medical Imaging-North East Netherlands, Department of Radiology, 
      University of Groningen, University Medical Center Groningen, Groningen, The 
      Netherlands.
FAU - Suranyi, Pal
AU  - Suranyi P
AD  - Division of Cardiovascular Imaging, Department of Radiology and Radiological 
      Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay 
      Drive, Charleston, SC, 29425-2260, USA.
LA  - eng
PT  - Journal Article
DEP - 20170103
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Contrast Media/*administration & dosage
MH  - Female
MH  - Gadolinium/*administration & dosage
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnostic imaging
MH  - Prospective Studies
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance
OT  - Late gadolinium enhancement
OT  - Myocardial infarct
OT  - Synthetic inversion recovery
OT  - T1 mapping
EDAT- 2017/01/05 06:00
MHDA- 2018/03/06 06:00
CRDT- 2017/01/05 06:00
PHST- 2016/04/13 00:00 [received]
PHST- 2016/11/17 00:00 [accepted]
PHST- 2016/08/24 00:00 [revised]
PHST- 2017/01/05 06:00 [pubmed]
PHST- 2018/03/06 06:00 [medline]
PHST- 2017/01/05 06:00 [entrez]
AID - 10.1007/s00330-016-4665-z [pii]
AID - 10.1007/s00330-016-4665-z [doi]
PST - ppublish
SO  - Eur Radiol. 2017 Aug;27(8):3235-3243. doi: 10.1007/s00330-016-4665-z. Epub 2017 
      Jan 3.