PMID- 28051256
OWN - NLM
STAT- MEDLINE
DCOM- 20170627
LR  - 20180318
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 20
IP  - 24
DP  - 2016 Dec
TI  - Expression of serum microRNA-378 and its clinical significance in laryngeal 
      squamous cell carcinoma.
PG  - 5137-5142
LID - 11922 [pii]
AB  - OBJECTIVE: Studies have demonstrated that miRNA -378 expressed in various 
      malignant tumors. In the present study, we aim to explore the expression of serum 
      miRNA-378 and its clinical significance in laryngeal squamous cell carcinoma 
      (LSCC) patients. PATIENTS AND METHODS: A total of 127 LSCC patients, 127 vocal 
      cord polyp (VCP) and 130 healthy controls were selected. RESULTS: The miRNA-378 
      level in LSCC and VCP group was significantly higher compared to healthy control, 
      and LSCC group has the highest miRNA-378 level. The miRNA-378 level was both 
      decreased significantly in LSCC and VCP group when compared with the same group 
      after surgery. When compared with healthy control, VCP group has a higher 
      miRNA-378 level but has no statistical difference (p>0.05) while LSCC group has a 
      statistical difference (p<0.05) higher miRNA-378 compare with healthy control. 
      The miRNA-378 expression is correlated with clinical stage and differentiation 
      degree, but did not correlate with patient's age, gender distribution, operation 
      mode, and tumor diameter. The AUC of miRNA-378 was 0.888, 95% confidence interval 
      was 0.849 to 0.929, and AUC hypothesis testing was statistically significant 
      (p<0.001). CONCLUSIONS: miRNA-378 could be used in the diagnosis and the 
      prediction of the postoperative curative effect of laryngeal cancer (LSCC).
FAU - Xu, Y
AU  - Xu Y
AD  - Department of Otorhinolaryngology, Department of Neurosurgery; Tianjin Medical 
      University General Hospital, Tianjin, China. huifzhou667@163.com.
FAU - Lin, Y-P
AU  - Lin YP
FAU - Yang, D
AU  - Yang D
FAU - Zhang, G
AU  - Zhang G
FAU - Zhou, H-F
AU  - Zhou HF
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (MIRN378 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics
MH  - MicroRNAs/*metabolism
EDAT- 2017/01/05 06:00
MHDA- 2017/06/28 06:00
CRDT- 2017/01/05 06:00
PHST- 2017/01/05 06:00 [entrez]
PHST- 2017/01/05 06:00 [pubmed]
PHST- 2017/06/28 06:00 [medline]
AID - 11922 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2016 Dec;20(24):5137-5142.