PMID- 28052241
OWN - NLM
STAT- MEDLINE
DCOM- 20171122
LR  - 20181113
IS  - 2211-1247 (Electronic)
VI  - 18
IP  - 1
DP  - 2017 Jan 3
TI  - Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration.
PG  - 107-121
LID - S2211-1247(16)31681-3 [pii]
LID - 10.1016/j.celrep.2016.12.008 [doi]
AB  - In rodents and humans, the liver can efficiently restore its mass after 
      hepatectomy. This is largely attributed to the proliferation and cell cycle 
      re-entry of hepatocytes. On the other hand, bone marrow cells (BMCs) migrate into 
      the liver after resection. Here, we find that a block of BMC recruitment into the 
      liver severely impairs its regeneration after the surgery. Mobilized 
      hematopoietic stem and progenitor cells (HSPCs) in the resected liver can fuse 
      with hepatocytes, and the hybrids proliferate earlier than the hepatocytes. 
      Genetic ablation of the hybrids severely impairs hepatocyte proliferation and 
      liver mass regeneration. Mathematical modeling reveals a key role of bone marrow 
      (BM)-derived hybrids to drive proliferation in the regeneration process, and 
      predicts regeneration efficiency in experimentally non-testable conditions. In 
      conclusion, BM-derived hybrids are essential to trigger efficient liver 
      regeneration after hepatectomy.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Pedone, Elisa
AU  - Pedone E
AD  - Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and 
      Technology, Dr Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra 
      (UPF), Dr Aiguader 88, 08003 Barcelona, Spain.
FAU - Olteanu, Vlad-Aris
AU  - Olteanu VA
AD  - Department of Engineering Mathematics, University of Bristol, Bristol BS8 1UB, 
      UK.
FAU - Marucci, Lucia
AU  - Marucci L
AD  - Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and 
      Technology, Dr Aiguader 88, 08003 Barcelona, Spain; Department of Engineering 
      Mathematics, University of Bristol, Bristol BS8 1UB, UK. Electronic address: 
      lucia.marucci@bristol.ac.uk.
FAU - Munoz-Martin, Maria Isabel
AU  - Munoz-Martin MI
AD  - Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and 
      Technology, Dr Aiguader 88, 08003 Barcelona, Spain.
FAU - Youssef, Sameh A
AU  - Youssef SA
AD  - Dutch Molecular Pathology Center, Department of Pathobiology, Faculty of 
      Veterinary Medicine, Utrecht University, 3584 Utrecht, the Netherlands; 
      Department of Pathology, Alexandria Veterinary College, University of 
      Alexandria-Egypt, 21612 Alexandria, Egypt.
FAU - de Bruin, Alain
AU  - de Bruin A
AD  - Dutch Molecular Pathology Center, Department of Pathobiology, Faculty of 
      Veterinary Medicine, Utrecht University, 3584 Utrecht, the Netherlands; 
      University Medical Center Groningen, Department of Pediatrics, University of 
      Groningen, 9713 Groningen, the Netherlands.
FAU - Cosma, Maria Pia
AU  - Cosma MP
AD  - Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and 
      Technology, Dr Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra 
      (UPF), Dr Aiguader 88, 08003 Barcelona, Spain; ICREA, Pg. Lluis Companys 23, 
      08010 Barcelona, Spain. Electronic address: pia.cosma@crg.es.
LA  - eng
GR  - MR/N021444/1/Medical Research Council/United Kingdom
GR  - BB/L01386X/1/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*cytology/*metabolism
MH  - Cell Fusion
MH  - Cell Proliferation
MH  - Gene Deletion
MH  - Hepatectomy
MH  - Hepatocytes/cytology
MH  - Liver/*physiology
MH  - Liver Regeneration/*physiology
MH  - Mice
MH  - *Models, Biological
MH  - Phenotype
MH  - Receptors, CXCR4/metabolism
PMC - PMC5236012
OTO - NOTNLM
OT  - cell fusion
OT  - cell migration
OT  - cell recruitment
OT  - hematopoietic stem cells
OT  - liver regeneration
OT  - mathematical modeling
OT  - partial hepatectomy
OT  - proliferation
OT  - systems biology
EDAT- 2017/01/05 06:00
MHDA- 2017/11/29 06:00
PMCR- 2017/01/03
CRDT- 2017/01/05 06:00
PHST- 2016/04/14 00:00 [received]
PHST- 2016/07/15 00:00 [revised]
PHST- 2016/12/01 00:00 [accepted]
PHST- 2017/01/05 06:00 [entrez]
PHST- 2017/01/05 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/01/03 00:00 [pmc-release]
AID - S2211-1247(16)31681-3 [pii]
AID - 10.1016/j.celrep.2016.12.008 [doi]
PST - ppublish
SO  - Cell Rep. 2017 Jan 3;18(1):107-121. doi: 10.1016/j.celrep.2016.12.008.