PMID- 2805289
OWN - NLM
STAT- MEDLINE
DCOM- 19891218
LR  - 20131121
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 80
IP  - 5 Pt 2
DP  - 1989 Nov
TI  - Coronary artery disease in cardiac transplant patients receiving triple-drug 
      immunosuppressive therapy.
PG  - III111-5
AB  - Although triple-drug immunosuppression with cyclosporine, prednisone, and 
      azathioprine has reduced the incidence of acute graft rejection after cardiac 
      transplant, its effect on the development of coronary artery disease is unknown. 
      We have followed up 74 cardiac transplant recipients with yearly coronary 
      angiograms. The probability of acute rejection was 10.8% at 1 year. The incidence 
      of coronary artery disease was 8% at 1 year (six of 74 patients) and 24% at 2 
      years (11 of 30 patients). In patients who developed posttransplant coronary 
      artery disease, there was a slightly higher, but not statistically significant, 
      incidence of acute graft rejection and pretransplant idiopathic cardiomyopathy. 
      No correlation was found between the incidence of coronary artery disease and 
      recipient age, human leukocyte antigen (HLA) type, hypertension, diabetes, 
      cholesterol level, triglyceride levels, weight gain after transplant, and 
      smoking. These data indicate that triple-drug immunosuppression, despite having 
      produced a significant reduction in the episodes of acute graft rejection, has 
      not decreased the incidence of posttransplant coronary artery disease. Common 
      risk factors for coronary disease and HLA mismatch are probably not important in 
      the pathogenesis of coronary atherosclerosis after cardiac transplantation, 
      whereas the risk for coronary artery disease may be increased by acute graft 
      rejection and pretransplant idiopathic cardiomyopathy.
FAU - Olivari, M T
AU  - Olivari MT
AD  - Department of Medicine, University of Minnesota Medical School, Minneapolis 
      55455.
FAU - Homans, D C
AU  - Homans DC
FAU - Wilson, R F
AU  - Wilson RF
FAU - Kubo, S H
AU  - Kubo SH
FAU - Ring, W S
AU  - Ring WS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Cyclosporins)
RN  - 0 (Immunosuppressive Agents)
RN  - MRK240IY2L (Azathioprine)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Azathioprine/therapeutic use
MH  - Coronary Disease/epidemiology/*etiology
MH  - Cyclosporins/therapeutic use
MH  - Female
MH  - Graft Rejection
MH  - *Heart Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Prednisone/therapeutic use
MH  - Risk Factors
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
PST - ppublish
SO  - Circulation. 1989 Nov;80(5 Pt 2):III111-5.