PMID- 28053247
OWN - NLM
STAT- MEDLINE
DCOM- 20170920
LR  - 20191210
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 117
IP  - 3
DP  - 2017 Mar 1
TI  - Heterogeneous effects of norepinephrine on spontaneous and stimulus-driven 
      activity in the male accessory olfactory bulb.
PG  - 1342-1351
LID - 10.1152/jn.00871.2016 [doi]
AB  - Norepinephrine (NE) release has been linked to experience-dependent plasticity in 
      many model systems and brain regions. Among these is the rodent accessory 
      olfactory system (AOS), which is crucial for detecting and processing socially 
      relevant environmental cues. The accessory olfactory bulb (AOB), the first site 
      of chemosensory information processing in the AOS, receives dense centrifugal 
      innervation by noradrenergic fibers originating in the locus coeruleus. Although 
      NE release has been linked to behavioral plasticity through its actions in the 
      AOB, the impacts of noradrenergic modulation on AOB information processing have 
      not been thoroughly studied. We made extracellular single-unit recordings of AOB 
      principal neurons in ex vivo preparations of the early AOS taken from adult male 
      mice. We analyzed the impacts of bath-applied NE (10 muM) on spontaneous and 
      stimulus-driven activity. In the presence of NE, we observed overall suppression 
      of stimulus-driven neuronal activity with limited impact on spontaneous activity. 
      NE-associated response suppression in the AOB came in two forms: one that was 
      strong and immediate (21%) and one other that involved gradual, 
      stimulus-dependent monotonic response suppression (47%). NE-associated changes in 
      spontaneous activity were more modest, with an overall increase in spontaneous 
      spike frequency observed in 25% of neurons. Neurons with increased spontaneous 
      activity demonstrated a net decrease in chemosensory discriminability. These 
      results reveal that noradrenergic signaling in the AOB causes cell-specific 
      changes in chemosensory tuning, even among similar projection neurons.NEW & 
      NOTEWORTHY Norepinephrine (NE) is released throughout the brain in many 
      behavioral contexts, but its impacts on information processing are not well 
      understood. We studied the impact of NE on chemosensory tuning in the mouse 
      accessory olfactory bulb (AOB). Electrophysiological recordings from AOB neurons 
      in ex vivo preparations revealed that NE, on balance, inhibited mitral cell 
      responses to chemosensory cues. However, NE's effects were heterogeneous, 
      indicating that NE signaling reshapes AOB output in a cell- and stimulus-specific 
      manner.
CI  - Copyright (c) 2017 the American Physiological Society.
FAU - Doyle, Wayne I
AU  - Doyle WI
AD  - Department of Neuroscience, University of Texas Southwestern Medical Center, 
      Dallas, Texas.
FAU - Meeks, Julian P
AU  - Meeks JP
AUID- ORCID: 0000-0002-7537-4491
AD  - Department of Neuroscience, University of Texas Southwestern Medical Center, 
      Dallas, Texas julian.meeks@utsouthwestern.edu.
LA  - eng
GR  - R00 DC011780/DC/NIDCD NIH HHS/United States
GR  - R01 DC015784/DC/NIDCD NIH HHS/United States
PT  - Journal Article
DEP - 20170104
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
RN  - 0 (Adrenergic alpha-Agonists)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Action Potentials/drug effects
MH  - Adrenergic alpha-Agonists/*pharmacology
MH  - Animals
MH  - Discrimination, Psychological
MH  - Female
MH  - In Vitro Techniques
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neurons/*drug effects
MH  - Norepinephrine/metabolism/*pharmacology
MH  - Olfactory Bulb/*cytology/*drug effects
MH  - Sex Characteristics
MH  - Signal Transduction/drug effects
MH  - Statistics, Nonparametric
MH  - Urine
PMC - PMC5350266
OTO - NOTNLM
OT  - accessory olfactory bulb
OT  - accessory olfactory system
OT  - chemical senses
OT  - information processing
OT  - norepinephrine
EDAT- 2017/01/06 06:00
MHDA- 2017/09/21 06:00
PMCR- 2018/03/01
CRDT- 2017/01/06 06:00
PHST- 2016/11/08 00:00 [received]
PHST- 2016/12/09 00:00 [revised]
PHST- 2017/01/03 00:00 [accepted]
PHST- 2017/01/06 06:00 [pubmed]
PHST- 2017/09/21 06:00 [medline]
PHST- 2017/01/06 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - jn.00871.2016 [pii]
AID - JN-00871-2016 [pii]
AID - 10.1152/jn.00871.2016 [doi]
PST - ppublish
SO  - J Neurophysiol. 2017 Mar 1;117(3):1342-1351. doi: 10.1152/jn.00871.2016. Epub 
      2017 Jan 4.