PMID- 28056388
OWN - NLM
STAT- MEDLINE
DCOM- 20170530
LR  - 20180613
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 128
IP  - 2
DP  - 2017 Feb
TI  - Aberrant temporal behavior of mismatch negativity generators in schizophrenia 
      patients and subjects at clinical high risk for psychosis.
PG  - 331-339
LID - S1388-2457(16)31007-0 [pii]
LID - 10.1016/j.clinph.2016.11.027 [doi]
AB  - OBJECTIVE: Although disconnection syndrome has been considered a core 
      pathophysiologic mechanism of schizophrenia, little is known about the temporal 
      behavior of mismatch negativity (MMN) generators in individuals with 
      schizophrenia or clinical high risk (CHR) for psychosis. METHODS: MMN was 
      assessed in 29 schizophrenia patients, 40 CHR subjects, and 47 healthy controls 
      (HCs). Individual realistic head models and the minimum L2 norm algorithm were 
      used to generate a current source density (CSD) model of MMN. The strength and 
      time course of MMN CSD activity were calculated separately for the frontal and 
      temporal cortices and were compared across brain regions and groups. RESULTS: 
      Schizophrenia patients and CHR subjects displayed lower MMN CSD strength than HCs 
      in both the temporal and frontal cortices. We found a significant time delay in 
      MMN generator activity in the frontal cortex relative to that in the temporal 
      cortex in HCs. However, the sequential temporo-frontal activities of MMN 
      generators were disrupted in both the schizophrenia and CHR groups. CONCLUSIONS: 
      Impairments and altered temporal behavior of MMN multiple generators were 
      observed even in individuals at risk for psychosis. SIGNIFICANCE: These findings 
      suggest that aberrant MMN generator activity might be helpful in revealing the 
      pathophysiology of schizophrenia.
CI  - Copyright (c) 2016 International Federation of Clinical Neurophysiology. Published 
      by Elsevier B.V. All rights reserved.
FAU - Kim, Minah
AU  - Kim M
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Cho, Kang Ik Kevin
AU  - Cho KI
AD  - Department of Brain and Cognitive Science, Seoul National University College of 
      Natural Science, Seoul, Republic of Korea.
FAU - Yoon, Youngwoo Bryan
AU  - Yoon YB
AD  - Department of Brain and Cognitive Science, Seoul National University College of 
      Natural Science, Seoul, Republic of Korea.
FAU - Lee, Tae Young
AU  - Lee TY
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea; Department of Brain and Cognitive Science, Seoul National 
      University College of Natural Science, Seoul, Republic of Korea; Institute of 
      Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. Electronic address: 
      kwonjs@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161218
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - *Connectome
MH  - Evoked Potentials
MH  - Female
MH  - Frontal Lobe/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Psychotic Disorders/diagnosis/*physiopathology
MH  - Schizophrenia/diagnosis/*physiopathology
MH  - Temporal Lobe/diagnostic imaging/physiopathology
OTO - NOTNLM
OT  - Clinical high risk for psychosis
OT  - Current source density
OT  - Disconnection syndrome
OT  - Mismatch negativity
OT  - Schizophrenia
EDAT- 2017/01/06 06:00
MHDA- 2017/05/31 06:00
CRDT- 2017/01/06 06:00
PHST- 2016/07/26 00:00 [received]
PHST- 2016/11/23 00:00 [revised]
PHST- 2016/11/26 00:00 [accepted]
PHST- 2017/01/06 06:00 [pubmed]
PHST- 2017/05/31 06:00 [medline]
PHST- 2017/01/06 06:00 [entrez]
AID - S1388-2457(16)31007-0 [pii]
AID - 10.1016/j.clinph.2016.11.027 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2017 Feb;128(2):331-339. doi: 10.1016/j.clinph.2016.11.027. 
      Epub 2016 Dec 18.