PMID- 28057363
OWN - NLM
STAT- MEDLINE
DCOM- 20171120
LR  - 20171128
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 230
DP  - 2017 Mar 1
TI  - Association of New York Heart Association functional class IV symptoms at 
      admission and clinical features with outcomes in patients hospitalized for acute 
      heart failure syndromes.
PG  - 585-591
LID - S0167-5273(16)34539-9 [pii]
LID - 10.1016/j.ijcard.2016.12.052 [doi]
AB  - BACKGROUND: It remains unclear whether there are subgroups of acute heart failure 
      syndromes (AHFS) patients in whom New York Heart Association (NYHA) class IV 
      symptoms at admission is related to a higher risk of mortality because of the 
      heterogeneity of this patient population. The aim of this study was to evaluate 
      the association of NYHA class IV symptoms at baseline with in-hospital mortality 
      in subgroups of patients with AHFS. METHODS AND RESULTS: Of the 4842 patients 
      enrolled in the Acute Decompensated Heart Failure Syndromes (ATTEND) registry, 
      4786 patients were included in this analysis. The primary endpoint was 
      in-hospital all-cause death. NYHA class IV at baseline was detected in 44.3% of 
      the patients. The all-cause death rate was significantly higher in patients with 
      NYHA class IV than in those with NYHA class II or III (9.0% vs. 4.3%, P<0.001). 
      To examine the heterogeneity of the association between NYHA class IV symptoms at 
      baseline and in-hospital mortality, subgroup analyses were performed. As a 
      result, the presence of NYHA class IV symptoms on admission was associated with a 
      significantly higher risk of all-cause death in patients aged >/=75years, female 
      patients, patients without an idiopathic dilated etiology, and patients with 
      preserved ejection fraction (EF). CONCLUSIONS: This study demonstrated that an 
      age>/=75years, female gender, the absence of idiopathic dilated etiology, and a 
      preserved EF should be considered when assessing the clinical significance of 
      NYHA class IV symptoms in relation to the risk of in-hospital mortality in 
      patients hospitalized for AHFS.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Asano, Ryotaro
AU  - Asano R
AD  - Department of Cardiology, Seirei Hamamatsu General Hospital, Shizuoka, Japan. 
      Electronic address: asano201@gmail.com.
FAU - Kajimoto, Katsuya
AU  - Kajimoto K
AD  - Division of Cardiology, Sekikawa Hospital, Tokyo, Japan.
FAU - Oka, Toshiaki
AU  - Oka T
AD  - Department of Cardiology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
FAU - Sugiura, Ryo
AU  - Sugiura R
AD  - Department of Cardiology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
FAU - Okada, Hisayuki
AU  - Okada H
AD  - Department of Cardiology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
FAU - Kamishima, Kazuho
AU  - Kamishima K
AD  - Department of Cardiology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
FAU - Hirata, Tetsuo
AU  - Hirata T
AD  - Department of Cardiology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
FAU - Sato, Naoki
AU  - Sato N
AD  - Internal Medicine, Cardiology, and Intensive Care Unit, Nippon Medical School 
      Musashi-Kosugi Hospital, Kanagawa, Japan.
CN  - investigators of the Acute Decompensated Heart Failure Syndromes (ATTEND) 
      registry
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20161226
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Cause of Death/trends
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*classification/diagnosis/mortality
MH  - Hospital Mortality/trends
MH  - Humans
MH  - *Inpatients
MH  - Japan/epidemiology
MH  - Male
MH  - *Patient Admission
MH  - Prognosis
MH  - Prospective Studies
MH  - *Registries
MH  - Risk Assessment/*methods
MH  - Severity of Illness Index
MH  - Syndrome
OTO - NOTNLM
OT  - Acute heart failure syndromes
OT  - Assessment
OT  - In-hospital outcome
OT  - New York Heart Association functional class
EDAT- 2017/01/07 06:00
MHDA- 2017/11/29 06:00
CRDT- 2017/01/07 06:00
PHST- 2016/06/20 00:00 [received]
PHST- 2016/11/12 00:00 [revised]
PHST- 2016/12/16 00:00 [accepted]
PHST- 2017/01/07 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/01/07 06:00 [entrez]
AID - S0167-5273(16)34539-9 [pii]
AID - 10.1016/j.ijcard.2016.12.052 [doi]
PST - ppublish
SO  - Int J Cardiol. 2017 Mar 1;230:585-591. doi: 10.1016/j.ijcard.2016.12.052. Epub 
      2016 Dec 26.