PMID- 28057720
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20210109
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 43
IP  - 2
DP  - 2017 Mar 1
TI  - Elevated Striatal Dopamine Function in Immigrants and Their Children: A Risk 
      Mechanism for Psychosis.
PG  - 293-301
LID - 10.1093/schbul/sbw181 [doi]
AB  - Migration is a major risk factor for schizophrenia but the neurochemical 
      processes involved are unknown. One candidate mechanism is through elevations in 
      striatal dopamine synthesis and release. The objective of this research was to 
      determine whether striatal dopamine function is elevated in immigrants compared 
      to nonimmigrants and the relationship with psychosis. Two complementary 
      case-control studies of in vivo dopamine function (stress-induced dopamine 
      release and dopamine synthesis capacity) in immigrants compared to nonimmigrants 
      were performed in Canada and the United Kingdom. The Canadian dopamine release 
      study included 25 immigrant and 31 nonmigrant Canadians. These groups included 23 
      clinical high risk (CHR) subjects, 9 antipsychotic naive patients with 
      schizophrenia, and 24 healthy volunteers. The UK dopamine synthesis study 
      included 32 immigrants and 44 nonimmigrant British. These groups included 50 CHR 
      subjects and 26 healthy volunteers. Both striatal stress-induced dopamine release 
      and dopamine synthesis capacity were significantly elevated in immigrants 
      compared to nonimmigrants, independent of clinical status. These data provide the 
      first evidence that the effect of migration on the risk of developing psychosis 
      may be mediated by an elevation in brain dopamine function.
CI  - (c) The Author 2017. Published by Oxford University Press on behalf of the Maryland 
      Psychiatric Research Center.
FAU - Egerton, Alice
AU  - Egerton A
AD  - Institute of Psychiatry, Psychology and Neuroscience, King's College London, 
      London, UK.
AD  - These authors are joint first authors.
FAU - Howes, Oliver D
AU  - Howes OD
AD  - Institute of Psychiatry, Psychology and Neuroscience, King's College London, 
      London, UK.
AD  - These authors are joint first authors.
FAU - Houle, Sylvain
AU  - Houle S
AD  - Research Imaging Center, CAMH, PET Centre, Toronto, ON, Canada.
AD  - Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, 
      ON, Canada.
AD  - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
AD  - These authors are joint first authors.
FAU - McKenzie, Kwame
AU  - McKenzie K
AD  - Research Imaging Center, CAMH, PET Centre, Toronto, ON, Canada.
AD  - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
FAU - Valmaggia, Lucia R
AU  - Valmaggia LR
AD  - Institute of Psychiatry, Psychology and Neuroscience, King's College London, 
      London, UK.
FAU - Bagby, Michael R
AU  - Bagby MR
AD  - Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, 
      ON, Canada.
AD  - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
AD  - Department of Psychology, University of Toronto.
FAU - Tseng, Huai-Hsuan
AU  - Tseng HH
AD  - Institute of Psychiatry, Psychology and Neuroscience, King's College London, 
      London, UK.
AD  - Research Imaging Center, CAMH, PET Centre, Toronto, ON, Canada.
FAU - Bloomfield, Michael A P
AU  - Bloomfield MA
AD  - Institute of Psychiatry, Psychology and Neuroscience, King's College London, 
      London, UK.
AD  - Division of Psychiatry, University College London, London, UK.
AD  - Psychiatric Imaging Group, MRC Clinical Sciences Centre, Hammersmith Hospital, 
      London, UK.
FAU - Kenk, Miran
AU  - Kenk M
AD  - Research Imaging Center, CAMH, PET Centre, Toronto, ON, Canada.
FAU - Bhattacharyya, Sagnik
AU  - Bhattacharyya S
AD  - Institute of Psychiatry, Psychology and Neuroscience, King's College London, 
      London, UK.
FAU - Suridjan, Ivonne
AU  - Suridjan I
AD  - Research Imaging Center, CAMH, PET Centre, Toronto, ON, Canada.
FAU - Chaddock, Chistopher A
AU  - Chaddock CA
AD  - Institute of Psychiatry, Psychology and Neuroscience, King's College London, 
      London, UK.
FAU - Winton-Brown, Toby T
AU  - Winton-Brown TT
AD  - Institute of Psychiatry, Psychology and Neuroscience, King's College London, 
      London, UK.
FAU - Allen, Paul
AU  - Allen P
AD  - Institute of Psychiatry, Psychology and Neuroscience, King's College London, 
      London, UK.
AD  - Department of Psychology, Whitelands College, University of Roehampton, London, 
      UK.
FAU - Rusjan, Pablo
AU  - Rusjan P
AD  - Research Imaging Center, CAMH, PET Centre, Toronto, ON, Canada.
AD  - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
FAU - Remington, Gary
AU  - Remington G
AD  - Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, 
      ON, Canada.
AD  - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
FAU - Meyer-Lindenberg, Andreas
AU  - Meyer-Lindenberg A
AD  - Central Institute of Mental Health, University of Heidelberg/Medical Faculty 
      Mannheim, Mannheim, Germany.
FAU - McGuire, Philip K
AU  - McGuire PK
AD  - Institute of Psychiatry, Psychology and Neuroscience, King's College London, 
      London, UK.
AD  - These authors are joint last authors.
FAU - Mizrahi, Romina
AU  - Mizrahi R
AD  - Research Imaging Center, CAMH, PET Centre, Toronto, ON, Canada.
AD  - Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, 
      ON, Canada.
AD  - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
AD  - These authors are joint last authors.
LA  - eng
GR  - MR/J012149/1/MRC_/Medical Research Council/United Kingdom
GR  - G0700995/MRC_/Medical Research Council/United Kingdom
GR  - MR/N026063/1/MRC_/Medical Research Council/United Kingdom
GR  - G0501775/MRC_/Medical Research Council/United Kingdom
GR  - MC_U120097115/MRC_/Medical Research Council/United Kingdom
GR  - NIHR-CS-011-001/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adult
MH  - Canada
MH  - Dopamine/*metabolism
MH  - *Emigrants and Immigrants
MH  - Female
MH  - Humans
MH  - Male
MH  - Neostriatum/diagnostic imaging/*metabolism
MH  - Positron-Emission Tomography
MH  - Psychotic Disorders/diagnostic imaging/*metabolism
MH  - Risk
MH  - Schizophrenia/diagnostic imaging/*metabolism
MH  - Stress, Psychological/diagnostic imaging/*metabolism
MH  - United Kingdom
MH  - Young Adult
PMC - PMC5605255
OTO - NOTNLM
OT  - positron emission tomography
OT  - schizophrenia
OT  - stress
EDAT- 2017/01/07 06:00
MHDA- 2017/07/25 06:00
PMCR- 2017/01/05
CRDT- 2017/01/07 06:00
PHST- 2017/01/07 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PHST- 2017/01/07 06:00 [entrez]
PHST- 2017/01/05 00:00 [pmc-release]
AID - sbw181 [pii]
AID - 10.1093/schbul/sbw181 [doi]
PST - ppublish
SO  - Schizophr Bull. 2017 Mar 1;43(2):293-301. doi: 10.1093/schbul/sbw181.