PMID- 28058227
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2220-3230 (Print)
IS  - 2220-3230 (Electronic)
IS  - 2220-3230 (Linking)
VI  - 6
IP  - 4
DP  - 2016 Dec 24
TI  - Magnetic resonance imaging of the transplanted pediatric heart as a potential 
      predictor of rejection.
PG  - 751-758
LID - 10.5500/wjt.v6.i4.751 [doi]
AB  - AIM: To evaluate cardiac magnetic resonance imaging (CMR) as a non-invasive tool 
      to detect acute cellular rejection (ACR) in children after heart transplant (HT). 
      METHODS: Thirty pediatric HT recipients underwent CMR at the time of surveillance 
      endomyocardial biopsy (EMB) and results were compared to 14 non-transplant 
      controls. Biventricular volumes, ejection fractions (EFs), T2-weighted signal 
      intensities, native T1 times, extracellular volumes (ECVs) and presence of late 
      gadolinium enhancement (LGE) were compared between patients and controls and 
      between patients with International Society of Heart and Lung Transplantation 
      (ISHLT) grade >/= 2R rejection and those with grade 0/1R. Heart rate (HR) and brain 
      natriuretic peptide (BNP) were assessed as potential biomarkers. RESULTS: 
      Significant ACR (ISHLT grade >/= 2R) was an infrequent event in our population 
      (5/30, 17%). Ventricular volumes, EFs, LGE prevalence, ECVs, native T1 times, T2 
      signal intensity ratios, HR and BNP were not associated with the presence of >/= 2R 
      ACR. CONCLUSION: In this pilot study CMR did not reliably identify ACR-related 
      changes in pediatric HT patients.
FAU - Greenway, Steven C
AU  - Greenway SC
AD  - Steven C Greenway, Department of Paediatrics, University of Calgary, Calgary, AB 
      T2N 1N4, Canada.
FAU - Dallaire, Frederic
AU  - Dallaire F
AD  - Steven C Greenway, Department of Paediatrics, University of Calgary, Calgary, AB 
      T2N 1N4, Canada.
FAU - Kantor, Paul F
AU  - Kantor PF
AD  - Steven C Greenway, Department of Paediatrics, University of Calgary, Calgary, AB 
      T2N 1N4, Canada.
FAU - Dipchand, Anne I
AU  - Dipchand AI
AD  - Steven C Greenway, Department of Paediatrics, University of Calgary, Calgary, AB 
      T2N 1N4, Canada.
FAU - Chaturvedi, Rajiv R
AU  - Chaturvedi RR
AD  - Steven C Greenway, Department of Paediatrics, University of Calgary, Calgary, AB 
      T2N 1N4, Canada.
FAU - Warade, Monali
AU  - Warade M
AD  - Steven C Greenway, Department of Paediatrics, University of Calgary, Calgary, AB 
      T2N 1N4, Canada.
FAU - Riesenkampff, Eugenie
AU  - Riesenkampff E
AD  - Steven C Greenway, Department of Paediatrics, University of Calgary, Calgary, AB 
      T2N 1N4, Canada.
FAU - Yoo, Shi-Joon
AU  - Yoo SJ
AD  - Steven C Greenway, Department of Paediatrics, University of Calgary, Calgary, AB 
      T2N 1N4, Canada.
FAU - Grosse-Wortmann, Lars
AU  - Grosse-Wortmann L
AD  - Steven C Greenway, Department of Paediatrics, University of Calgary, Calgary, AB 
      T2N 1N4, Canada.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Transplant
JT  - World journal of transplantation
JID - 101608356
PMC - PMC5175235
OTO - NOTNLM
OT  - Heart
OT  - Magnetic resonance imaging
OT  - Pediatric
OT  - Rejection
OT  - Transplantation
COIS- Conflict-of-interest statement: The authors of this manuscript have no conflicts 
      of interest to disclose.
EDAT- 2017/01/07 06:00
MHDA- 2017/01/07 06:01
PMCR- 2016/12/24
CRDT- 2017/01/07 06:00
PHST- 2016/07/19 00:00 [received]
PHST- 2016/11/04 00:00 [revised]
PHST- 2016/11/27 00:00 [accepted]
PHST- 2017/01/07 06:00 [entrez]
PHST- 2017/01/07 06:00 [pubmed]
PHST- 2017/01/07 06:01 [medline]
PHST- 2016/12/24 00:00 [pmc-release]
AID - 10.5500/wjt.v6.i4.751 [doi]
PST - ppublish
SO  - World J Transplant. 2016 Dec 24;6(4):751-758. doi: 10.5500/wjt.v6.i4.751.