PMID- 28059450
OWN - NLM
STAT- MEDLINE
DCOM- 20190123
LR  - 20190123
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 232
IP  - 12
DP  - 2017 Dec
TI  - KCNQ1 variants associate with hypertension in type 2 diabetes and affect smooth 
      muscle contractility in vitro.
PG  - 3309-3316
LID - 10.1002/jcp.25775 [doi]
AB  - KCNQ1 encodes a potassium voltage-gated channel and represents a susceptibility 
      locus for type 2 diabetes mellitus (T2DM). Here, we explored the association 
      between KCNQ1 polymorphisms and hypertension risk in individuals with T2DM, as 
      well as the role of KCNQ1 in vascular smooth muscle cell contraction in vitro. To 
      investigate the relationship between KCNQ1 and the risk of developing 
      hypertension in patients with T2DM, we divided the T2DM cohort into hypertension 
      (n = 452) and non-hypertension (n = 541) groups. The Mann-Whitney U test, 
      chi-square test, and multivariate regression analyses were used to assess the 
      clinical characteristics and genotypic frequencies. In vitro studies utilized the 
      rat aortic smooth muscle A10 cell line. Patients in the hypertension group were 
      significantly older at the time of enrollment and had higher levels of body mass 
      index, waist-to-hip ratio, and triglyceride than those in the non-hypertension 
      group. The KCNQ1 rs3864884 and rs12576239 genetic variants were associated with 
      hypertension in T2DM. KCNQ1 expression was lower in the individuals with the CC 
      versus the CT and TT genotypes. Smooth muscle cell contractility was inhibited by 
      treatment with a KCNQ1 inhibitor. These results suggest that KCNQ1 might be 
      associated with hypertension in individuals with T2DM.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Huang, Kuo-Chin
AU  - Huang KC
AD  - School of Chinese Medicine, China Medical University, Taichung, Taiwan.
AD  - Department of Integration of Traditional Chinese and Western Medicine, China 
      Medical University Hospital, Taichung, Taiwan.
FAU - Li, Te-Mao
AU  - Li TM
AD  - School of Chinese Medicine, China Medical University, Taichung, Taiwan.
FAU - Liu, Xiang
AU  - Liu X
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland.
FAU - Chen, Jin-Hua
AU  - Chen JH
AD  - Biostatistics Center and School of Public Health, China Medical University, 
      Taichung, Taiwan.
AD  - Biostatistics Center and School of Public Health, Taipei Medical University, 
      Taipei, Taiwan.
FAU - Chien, Wen-Kuei
AU  - Chien WK
AD  - National Applied Research Laboratories, National Center for High-Performance 
      Computing, Hsinchu, Taiwan.
FAU - Shiao, Yi-Tzone
AU  - Shiao YT
AD  - Heart Center, China Medical University Hospital, Taichung, Taiwan.
FAU - Tsang, Hsinyi
AU  - Tsang H
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland.
FAU - Lin, Ting-Hsu
AU  - Lin TH
AD  - Genetic Center, Department of Medical Research, China Medical University 
      Hospital, Taichung, Taiwan.
FAU - Liao, Chiu-Chu
AU  - Liao CC
AD  - Genetic Center, Department of Medical Research, China Medical University 
      Hospital, Taichung, Taiwan.
FAU - Huang, Shao-Mei
AU  - Huang SM
AD  - Genetic Center, Department of Medical Research, China Medical University 
      Hospital, Taichung, Taiwan.
FAU - Li, Ju-Pi
AU  - Li JP
AD  - School of Chinese Medicine, China Medical University, Taichung, Taiwan.
AD  - Rheumatism Research Center, China Medical University Hospital, Taichung, Taiwan.
FAU - Lin, Cheng-Wen
AU  - Lin CW
AD  - Department of Medical Laboratory Science and Biotechnology, China Medical 
      University, Taichung, Taiwan.
FAU - Lin, Jung-Chun
AU  - Lin JC
AD  - School of Medical Laboratory Science and Biotechnology, College of Medical 
      Science and Technology, Taipei Medical University, Taipei, Taiwan.
FAU - Lin, Chih-Chien
AU  - Lin CC
AD  - Department of Cosmetic Science, Providence University, Taichung, Taiwan.
FAU - Lai, Chih-Ho
AU  - Lai CH
AD  - Department of Microbiology and Immunology, Chang Gung University, Taoyuan, 
      Taiwan.
FAU - Cheng, Chi-Fung
AU  - Cheng CF
AD  - Graduate Institute of Biostatistics, School of Public Health, China Medical 
      University, Taichung, Taiwan.
FAU - Liang, Wen-Miin
AU  - Liang WM
AD  - Graduate Institute of Biostatistics, School of Public Health, China Medical 
      University, Taichung, Taiwan.
FAU - Hung, Chien-Hui
AU  - Hung CH
AD  - Graduate Institute of Clinical Medical Science, Chang-Gung University, Taipei, 
      Taiwan.
FAU - Chen, Ching-Chu
AU  - Chen CC
AD  - School of Chinese Medicine, China Medical University, Taichung, Taiwan.
AD  - Division of Endocrinology and Metabolism, Department of Medicine, China Medical 
      University Hospital, Taichung, Taiwan.
FAU - Lin, Ying-Ju
AU  - Lin YJ
AUID- ORCID: 0000-0003-4684-0585
AD  - School of Chinese Medicine, China Medical University, Taichung, Taiwan.
AD  - Genetic Center, Department of Medical Research, China Medical University 
      Hospital, Taichung, Taiwan.
FAU - Tsai, Fuu-Jen
AU  - Tsai FJ
AD  - School of Chinese Medicine, China Medical University, Taichung, Taiwan.
AD  - Genetic Center, Department of Medical Research, China Medical University 
      Hospital, Taichung, Taiwan.
AD  - Asia University, Taichung, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20170410
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (KCNQ1 Potassium Channel)
RN  - 0 (KCNQ1 protein, human)
RN  - 0 (Kcnq1 protein, rat)
SB  - IM
MH  - Aged
MH  - Animals
MH  - Cell Line
MH  - Diabetes Mellitus, Type 2/complications/*genetics
MH  - Female
MH  - *Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Hypertension/complications/*genetics
MH  - KCNQ1 Potassium Channel/*genetics
MH  - Male
MH  - Middle Aged
MH  - Muscle Contraction
MH  - Muscle, Smooth/*physiology
MH  - Rats
OTO - NOTNLM
OT  - KCNQ1
OT  - genetic variants
OT  - hypertension
OT  - muscle contractility
OT  - type 2 diabetes
EDAT- 2017/01/07 06:00
MHDA- 2019/01/24 06:00
CRDT- 2017/01/07 06:00
PHST- 2016/08/27 00:00 [received]
PHST- 2016/12/23 00:00 [revised]
PHST- 2017/01/05 00:00 [accepted]
PHST- 2017/01/07 06:00 [pubmed]
PHST- 2019/01/24 06:00 [medline]
PHST- 2017/01/07 06:00 [entrez]
AID - 10.1002/jcp.25775 [doi]
PST - ppublish
SO  - J Cell Physiol. 2017 Dec;232(12):3309-3316. doi: 10.1002/jcp.25775. Epub 2017 Apr 
      10.