PMID- 28059602
OWN - NLM
STAT- MEDLINE
DCOM- 20170619
LR  - 20211204
IS  - 1551-4005 (Electronic)
IS  - 1538-4101 (Print)
IS  - 1551-4005 (Linking)
VI  - 16
IP  - 4
DP  - 2017 Feb 16
TI  - SUMOylation of KLF4 promotes IL-4 induced macrophage M2 polarization.
PG  - 374-381
LID - 10.1080/15384101.2016.1269045 [doi]
AB  - Macrophages, in response to different environmental cues, undergo the classical 
      polarization (M1 macrophages) as well as the alternative polarization (M2 
      macrophages) that involve the functions of stimulus-specific transcription 
      factors. Kruppel-like factor 4 (KLF4), a member of a subfamily of the zinc-finger 
      class of DNA-binding transcription factors, plays as a critical regulator of 
      macrophage polarization. KLF4 has been reported as a SUMOylated protein. In this 
      study, we showed that SUMOylation of KLF4, is induced by IL-4 treatment in 
      macrophages. IL4-induced KLF4 SUMOylation promotes RAW264.7 cells and bone marrow 
      derived macrophages (BMDMs) to polarize into M2 subset. Thus, we identified an 
      important post-translational modification (PTM), SUMOylation, plays a crucial 
      role in regulating KLF4 activity during IL-4 induced macrophage M2 polarization. 
      SUMOylation of KLF4 can be a potential therapeutic target in the resolution of 
      inflammation.
FAU - Wang, Kezhou
AU  - Wang K
AD  - a Department of Biochemistry and Molecular Cell Biology , Shanghai Jiaotong 
      University School of Medicine , Shanghai , China.
AD  - b Department of Pathophysiology , Dalian Medical University , Dalian , China.
FAU - Zhou, Wei
AU  - Zhou W
AD  - a Department of Biochemistry and Molecular Cell Biology , Shanghai Jiaotong 
      University School of Medicine , Shanghai , China.
FAU - Cai, Qi
AU  - Cai Q
AD  - a Department of Biochemistry and Molecular Cell Biology , Shanghai Jiaotong 
      University School of Medicine , Shanghai , China.
AD  - c Department of Clinical Laboratory , Ruijin Hospital, Shanghai Jiaotong 
      University School of Medicine , Shanghai , China.
FAU - Cheng, Jinke
AU  - Cheng J
AD  - a Department of Biochemistry and Molecular Cell Biology , Shanghai Jiaotong 
      University School of Medicine , Shanghai , China.
FAU - Cai, Rong
AU  - Cai R
AD  - a Department of Biochemistry and Molecular Cell Biology , Shanghai Jiaotong 
      University School of Medicine , Shanghai , China.
FAU - Xing, Rong
AU  - Xing R
AD  - b Department of Pathophysiology , Dalian Medical University , Dalian , China.
LA  - eng
PT  - Journal Article
DEP - 20170106
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
RN  - 0 (KLF4 protein, human)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 207137-56-2 (Interleukin-4)
RN  - EC 3.5.3.1 (Arginase)
SB  - IM
MH  - Animals
MH  - Arginase/genetics
MH  - Cell Line
MH  - Cell Polarity/*drug effects
MH  - Humans
MH  - Interleukin-4/*pharmacology
MH  - Kruppel-Like Factor 4
MH  - Kruppel-Like Transcription Factors/*metabolism
MH  - Macrophages/*cytology/drug effects/*metabolism
MH  - Mice
MH  - Models, Biological
MH  - Promoter Regions, Genetic/genetics
MH  - Protein Binding/drug effects
MH  - Sumoylation/*drug effects
PMC - PMC5324751
OTO - NOTNLM
OT  - IL-4
OT  - Kruppel-like factor 4 (KLF4)
OT  - SUMOylation
OT  - alternative polarization
OT  - macrophage
EDAT- 2017/01/07 06:00
MHDA- 2017/06/20 06:00
PMCR- 2018/01/06
CRDT- 2017/01/07 06:00
PHST- 2017/01/07 06:00 [pubmed]
PHST- 2017/06/20 06:00 [medline]
PHST- 2017/01/07 06:00 [entrez]
PHST- 2018/01/06 00:00 [pmc-release]
AID - 1269045 [pii]
AID - 10.1080/15384101.2016.1269045 [doi]
PST - ppublish
SO  - Cell Cycle. 2017 Feb 16;16(4):374-381. doi: 10.1080/15384101.2016.1269045. Epub 
      2017 Jan 6.