PMID- 28061144
OWN - NLM
STAT- MEDLINE
DCOM- 20171013
LR  - 20190109
IS  - 1557-8682 (Electronic)
IS  - 1527-0297 (Print)
IS  - 1527-0297 (Linking)
VI  - 18
IP  - 1
DP  - 2017 Mar
TI  - Long-Term Health Outcomes in High-Altitude Pulmonary Hypertension.
PG  - 61-66
LID - 10.1089/ham.2016.0098 [doi]
AB  - Robinson, Jeffrey C., Cheryl Abbott, Christina A. Meadows, Robert C. Roach, 
      Benjamin Honigman, and Todd M. Bull. Long-term health outcomes in high-altitude 
      pulmonary hypertension. High Alt Med Biol. 18:61-66, 2017. BACKGROUND: 
      High-altitude pulmonary hypertension (HAPH) is one of several known comorbidities 
      that effect populations living at high altitude, but there have been no studies 
      looking at long-term health consequences of HAPH. We aimed to determine whether 
      HAPH during adolescence predisposes to significant pulmonary hypertension (PH) 
      later in life, as well as identify how altitude exposure and HAPH correlate with 
      functional class and medical comorbidities. METHODS: We utilized a previously 
      published cohort of 28 adolescents from Leadville, Colorado, that underwent right 
      heart catheterization at 10,150 ft (3094 m) in 1962, with many demonstrating PH 
      as defined by resting mean pulmonary arterial pressure >/=25 mmHg. We located 
      participants of the original study and had living subjects complete demographic 
      and health surveys to assess for the presence of PH and other medical 
      comorbidities, along with current functional status. RESULTS: Seventy-five 
      percent of the individuals who participated in the original study were located. 
      Those with HAPH in the past were more prone to have exertional limitation 
      corresponding to WHO functional class >1. Fifty-five years following the original 
      study, we found no significant differences in prevalence of medical 
      comorbidities, including PH, among those with and without HAPH in their youth. 
      CONCLUSIONS: Surveyed individuals did not report significant PH, but those with 
      HAPH in their youth were more likely to report functional limitation. With a 
      significant worldwide population living at moderate and high altitudes, further 
      study of long-term health consequences is warranted.
FAU - Robinson, Jeffrey C
AU  - Robinson JC
AD  - 1 Colorado Pulmonary Vascular Disease Center, Division of Pulmonary Sciences and 
      Critical Care Medicine, Department of Medicine, University of Colorado School of 
      Medicine , Aurora, Colorado.
FAU - Abbott, Cheryl
AU  - Abbott C
AD  - 1 Colorado Pulmonary Vascular Disease Center, Division of Pulmonary Sciences and 
      Critical Care Medicine, Department of Medicine, University of Colorado School of 
      Medicine , Aurora, Colorado.
FAU - Meadows, Christina A
AU  - Meadows CA
AD  - 1 Colorado Pulmonary Vascular Disease Center, Division of Pulmonary Sciences and 
      Critical Care Medicine, Department of Medicine, University of Colorado School of 
      Medicine , Aurora, Colorado.
FAU - Roach, Robert C
AU  - Roach RC
AD  - 2 Altitude Research Center and Department of Emergency Medicine, University of 
      Colorado School of Medicine , Aurora, Colorado.
FAU - Honigman, Benjamin
AU  - Honigman B
AD  - 2 Altitude Research Center and Department of Emergency Medicine, University of 
      Colorado School of Medicine , Aurora, Colorado.
FAU - Bull, Todd M
AU  - Bull TM
AD  - 1 Colorado Pulmonary Vascular Disease Center, Division of Pulmonary Sciences and 
      Critical Care Medicine, Department of Medicine, University of Colorado School of 
      Medicine , Aurora, Colorado.
LA  - eng
PT  - Journal Article
DEP - 20170106
PL  - United States
TA  - High Alt Med Biol
JT  - High altitude medicine & biology
JID - 100901183
RN  - Pulmonary edema of mountaineers
SB  - IM
MH  - Adolescent
MH  - Aged
MH  - *Altitude
MH  - Altitude Sickness/*physiopathology
MH  - Cohort Studies
MH  - Colorado
MH  - Female
MH  - Follow-Up Studies
MH  - Health Surveys
MH  - Humans
MH  - Hypertension, Pulmonary/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - *Patient Outcome Assessment
MH  - *Time Factors
PMC - PMC5361756
OTO - NOTNLM
OT  - high-altitude population health
OT  - high-altitude pulmonary hypertension
OT  - hypoxic pulmonary hypertension
COIS- No competing financial interests exist.
EDAT- 2017/01/07 06:00
MHDA- 2017/10/14 06:00
PMCR- 2018/03/01
CRDT- 2017/01/07 06:00
PHST- 2017/01/07 06:00 [pubmed]
PHST- 2017/10/14 06:00 [medline]
PHST- 2017/01/07 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - 10.1089/ham.2016.0098 [pii]
AID - 10.1089/ham.2016.0098 [doi]
PST - ppublish
SO  - High Alt Med Biol. 2017 Mar;18(1):61-66. doi: 10.1089/ham.2016.0098. Epub 2017 
      Jan 6.